Reactome | UniProt:P68871 HBB

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UniProt:P68871 HBB Show undefined attributes

chain	initiator methionine:1 chain:2-147 peptide:33-42 peptide:33-39
checksum	A31F6D621C6556A1
comment	FUNCTION Involved in oxygen transport from the lung to the various peripheral tissues.FUNCTION LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.FUNCTION Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.SUBUNIT Heterotetramer of two alpha chains and two beta chains in adult hemoglobin A (HbA). Heterotetramer of two zeta chains and two beta chains in hemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassemia.INTERACTION Red blood cells.PTM Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus.PTM S-nitrosylated; a nitric oxide group is first bound to Fe(2+) and then transferred to Cys-94 to allow capture of O(2).PTM Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin exposure.MASS SPECTROMETRY Genetic variations in HBB are involved in resistance to malaria [MIM:611162]. Hemoglobin S (Hb S), which at homozygosity is responsible for sickle cell anemia, is not associated with any clinical abnormality when heterozygous. At heterozygosity, Hb S confers an increase in protection from life-threatening malaria. Additional variants conferring resistance against severe malaria are hemoglobin C (Hb C) and hemoglobin E (Hb E).DISEASE The disease may be caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS One molecule of 2,3-bisphosphoglycerate can bind to two beta chains per hemoglobin tetramer.SIMILARITY Belongs to the globin family.CAUTION The modification form of Leu-142 is subject of controversy and could be the artifactual result of sample handling.CAUTION It is unclear if hemoglobin Beckman (Hb Beckman) is defined by p.Ala136Glu or p.Ala136Asp. Hb Beckman has been originally identified by reverse phase-HPLC and tandem mass spectrometry, and has been reported as variant p.Ala136Glu (Ref.140). Subsequently, variant p.Ala136Asp has been reported based on HBB gene complete sequencing results (PubMed:19453576). Variant p.Ala136Asp has also been detected by mass spectrometry (PubMed:26209877). Although the name Hb Beckman is currently used for variant p.Ala136Asp, it cannot be ruled out that Hb Beckman is indeed variant p.Ala136Glu (PubMed:19453576).ONLINE INFORMATION Human hemoglobin variants and thalassemiasONLINE INFORMATION Hemoglobin entry
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:11796973] GeneCards:HBB [DatabaseIdentifier:12350277] RefSeq:NP_000509.1 [DatabaseIdentifier:12294803] Pharos - Targets:P68871 [DatabaseIdentifier:12257345] PRO:P68871 [DatabaseIdentifier:12217926] PDB:1VWT [DatabaseIdentifier:12217927] PDB:4XS0 [DatabaseIdentifier:12217925] PDB:1K0Y [DatabaseIdentifier:12217847] PDB:1AJ9 [DatabaseIdentifier:12217849] PDB:9BCJ [DatabaseIdentifier:12217902] PDB:9AV9 [DatabaseIdentifier:12217905] PDB:6LCW [DatabaseIdentifier:12217915] PDB:3P5Q [DatabaseIdentifier:12217864] PDB:7JJQ [DatabaseIdentifier:12217839] PDB:1QXD [DatabaseIdentifier:12217884] PDB:1COH [DatabaseIdentifier:12235250] PDB:1CBM [DatabaseIdentifier:12217837] PDB:1QXE [DatabaseIdentifier:12217919] PDB:6BB5 [DatabaseIdentifier:12217889] PDB:3SZK [DatabaseIdentifier:12217861] PDB:3IC2 [DatabaseIdentifier:12217850] PDB:3ONZ [DatabaseIdentifier:12217836] PDB:4NI0 [DatabaseIdentifier:12217872] PDB:1YIH [DatabaseIdentifier:12217885] PDB:5UFJ [DatabaseIdentifier:12217881] PDB:3B75 [DatabaseIdentifier:12217899] PDB:2HHB [DatabaseIdentifier:12217854] PDB:2HCO [DatabaseIdentifier:12217876] PDB:1XYE [DatabaseIdentifier:12217916] PDB:1GZX [DatabaseIdentifier:12217920] PDB:5SW7 [DatabaseIdentifier:12217912] PDB:6KAP [DatabaseIdentifier:12217890] PDB:7XGY [DatabaseIdentifier:12217846] PDB:1HGA [DatabaseIdentifier:12217843] PDB:1HGC [DatabaseIdentifier:12217904] PDB:6KAV [DatabaseIdentifier:12149445] PDB:9FNO [DatabaseIdentifier:12195846] PDB:4WJG [DatabaseIdentifier:12217903] PDB:6LCX [DatabaseIdentifier:12217869] PDB:1XY0 [DatabaseIdentifier:12217906] PDB:1XZV [DatabaseIdentifier:12217924] PDB:7UD7 [DatabaseIdentifier:12217898] PDB:2HHD [DatabaseIdentifier:12217882] PDB:5KSI [DatabaseIdentifier:12217878] PDB:6BNR [DatabaseIdentifier:12217851] PDB:1Y85 [DatabaseIdentifier:12217866] PDB:2DN1 [DatabaseIdentifier:12217921] PDB:7UD8 [DatabaseIdentifier:12217873] PDB:1YIE [DatabaseIdentifier:12217917] PDB:1K1K [DatabaseIdentifier:12217909] PDB:6KAO [DatabaseIdentifier:12217892] PDB:1XZ7 [DatabaseIdentifier:12217857] PDB:3OO4 [DatabaseIdentifier:12195847] PDB:4X0L [DatabaseIdentifier:12217887] PDB:6KAI [DatabaseIdentifier:12217855] PDB:1QI8 [DatabaseIdentifier:12217865] PDB:2DN2 [DatabaseIdentifier:12217845] PDB:1YHR [DatabaseIdentifier:12217910] PDB:7VDE [DatabaseIdentifier:12217886] PDB:6KAE [DatabaseIdentifier:12217832] PDB:3D7O [DatabaseIdentifier:12217901] PDB:6KAT [DatabaseIdentifier:12217875] PDB:4L7Y [DatabaseIdentifier:12217858] PDB:3OO5 [DatabaseIdentifier:12217880] PDB:5KSJ [DatabaseIdentifier:12217891] PDB:5E83 [DatabaseIdentifier:12217860] PDB:1Y7Z [DatabaseIdentifier:12235251] PDB:1CBL [DatabaseIdentifier:12217838] PDB:4NI1 [DatabaseIdentifier:12217897] PDB:2HHE [DatabaseIdentifier:12217879] PDB:1XXT [DatabaseIdentifier:12217867] PDB:5E6E [DatabaseIdentifier:12217863] PDB:2DN3 [DatabaseIdentifier:12217922] PDB:3WCP [DatabaseIdentifier:12217893] PDB:6KA9 [DatabaseIdentifier:12217868] PDB:1HHO [DatabaseIdentifier:12217907] PDB:1XZU [DatabaseIdentifier:12217853] PDB:1Y83 [DatabaseIdentifier:12217874] PDB:6HK2 [DatabaseIdentifier:12217841] PDB:3NL7 [DatabaseIdentifier:12195845] PDB:6TB2 [DatabaseIdentifier:12217871] PDB:1Y8W [DatabaseIdentifier:12149439] PDB:9FMU [DatabaseIdentifier:12217911] PDB:6KAQ [DatabaseIdentifier:12217844] PDB:1HGB [DatabaseIdentifier:12217918] PDB:1G9V [DatabaseIdentifier:12217894] PDB:1NEJ [DatabaseIdentifier:12217896] PDB:1XZ4 [DatabaseIdentifier:12217834] PDB:1YGD [DatabaseIdentifier:12217840] PDB:7PCQ [DatabaseIdentifier:12217842] PDB:3NMM [DatabaseIdentifier:12217877] PDB:1XZ2 [DatabaseIdentifier:12217856] PDB:3S66 [DatabaseIdentifier:12217862] PDB:1YZI [DatabaseIdentifier:12217908] PDB:5KDQ [DatabaseIdentifier:12217870] PDB:3R5I [DatabaseIdentifier:12217883] PDB:5NI1 [DatabaseIdentifier:12217888] PDB:6KAH [DatabaseIdentifier:12217914] PDB:6KAR [DatabaseIdentifier:12217859] PDB:3IC0 [DatabaseIdentifier:12217852] PDB:1YHE [DatabaseIdentifier:12217835] PDB:7JY3 [DatabaseIdentifier:12217923] PDB:8DOV [DatabaseIdentifier:12217913] PDB:6KAS [DatabaseIdentifier:12217895] PDB:1XZ5 [DatabaseIdentifier:12217833] PDB:7JY1 [DatabaseIdentifier:12217848] PDB:1CMY [DatabaseIdentifier:12217900] PDB:6KAU [DatabaseIdentifier:12217761] PDB:4ROM [DatabaseIdentifier:12217755] PDB:1O1J [DatabaseIdentifier:12217783] PDB:1Y4R [DatabaseIdentifier:12217821] PDB:5UCU [DatabaseIdentifier:12217794] PDB:1YG5 [DatabaseIdentifier:12217782] PDB:2YRS [DatabaseIdentifier:12217778] PDB:1YEV [DatabaseIdentifier:12217777] PDB:1Y5F [DatabaseIdentifier:12217803] PDB:1NQP [DatabaseIdentifier:12217824] PDB:4N8T [DatabaseIdentifier:12217800] PDB:7PCF [DatabaseIdentifier:12217741] PDB:9CQP [DatabaseIdentifier:12217739] PDB:9CQR [DatabaseIdentifier:12217766] PDB:1O1P [DatabaseIdentifier:12217743] PDB:1RVW [DatabaseIdentifier:12217822] PDB:1CLS [DatabaseIdentifier:12217801] PDB:4N7N [DatabaseIdentifier:12217750] PDB:9CQN [DatabaseIdentifier:12217768] PDB:1O1O [DatabaseIdentifier:12217827] PDB:5U3I [DatabaseIdentifier:12217751] PDB:1Y45 [DatabaseIdentifier:12217745] PDB:9CQS [DatabaseIdentifier:12217813] PDB:1GBU [DatabaseIdentifier:12217825] PDB:1Y7G [DatabaseIdentifier:12217773] PDB:1O1M [DatabaseIdentifier:12149446] PDB:8XMP [DatabaseIdentifier:12217830] PDB:2HBS [DatabaseIdentifier:12217759] PDB:1YEQ [DatabaseIdentifier:12217752] PDB:1HBS [DatabaseIdentifier:12217736] PDB:6XD9 [DatabaseIdentifier:12235249] PDB:6FQF [DatabaseIdentifier:12217758] PDB:1J7S [DatabaseIdentifier:12217807] PDB:2HBD [DatabaseIdentifier:12217740] PDB:9CQO [DatabaseIdentifier:12149447] PDB:9FHB [DatabaseIdentifier:12217756] PDB:1O1I [DatabaseIdentifier:12217818] PDB:1BZZ [DatabaseIdentifier:12217779] PDB:5E29 [DatabaseIdentifier:12217809] PDB:1YVT [DatabaseIdentifier:12217793] PDB:7AET [DatabaseIdentifier:12217737] PDB:2DXM [DatabaseIdentifier:12217787] PDB:1B86 [DatabaseIdentifier:12217770] PDB:6XDT [DatabaseIdentifier:12217786] PDB:1HCO [DatabaseIdentifier:12217805] PDB:2HBF [DatabaseIdentifier:12217764] PDB:5URC [DatabaseIdentifier:12217781] PDB:1YEU [DatabaseIdentifier:12217831] PDB:7JY0 [DatabaseIdentifier:12217785] PDB:1Y4P [DatabaseIdentifier:12217762] PDB:1YEO [DatabaseIdentifier:12217806] PDB:2HBE [DatabaseIdentifier:12217815] PDB:1YFF [DatabaseIdentifier:12217823] PDB:1YH9 [DatabaseIdentifier:12217828] PDB:7JXZ [DatabaseIdentifier:12217767] PDB:1Y5J [DatabaseIdentifier:12217747] PDB:1DKE [DatabaseIdentifier:12217765] PDB:1Y5K [DatabaseIdentifier:12217763] PDB:1YEN [DatabaseIdentifier:12217810] PDB:1YVQ [DatabaseIdentifier:12217746] PDB:9CQT [DatabaseIdentifier:12217814] PDB:1BZ1 [DatabaseIdentifier:12217812] PDB:1GBV [DatabaseIdentifier:12217776] PDB:1O1L [DatabaseIdentifier:12217796] PDB:6NBD [DatabaseIdentifier:12217808] PDB:1BZ0 [DatabaseIdentifier:12217816] PDB:1Y7D [DatabaseIdentifier:12217797] PDB:7AEU [DatabaseIdentifier:12217790] PDB:4M4B [DatabaseIdentifier:12217784] PDB:1Y4Q [DatabaseIdentifier:12149441] PDB:8XMW [DatabaseIdentifier:12217829] PDB:1YGF [DatabaseIdentifier:12217789] PDB:4M4A [DatabaseIdentifier:12217754] PDB:1JY7 [DatabaseIdentifier:12217780] PDB:1O1K [DatabaseIdentifier:12217753] PDB:1LJW [DatabaseIdentifier:12217804] PDB:4N7P [DatabaseIdentifier:12217769] PDB:5HY8 [DatabaseIdentifier:12217742] PDB:9CQU [DatabaseIdentifier:12217817] PDB:1Y7C [DatabaseIdentifier:12217775] PDB:1J7W [DatabaseIdentifier:12217819] PDB:5EE4 [DatabaseIdentifier:12217792] PDB:6NBC [DatabaseIdentifier:12217799] PDB:1BIJ [DatabaseIdentifier:12217826] PDB:2H35 [DatabaseIdentifier:12217802] PDB:4N7O [DatabaseIdentifier:12217749] PDB:1Y46 [DatabaseIdentifier:12217738] PDB:9CQQ [DatabaseIdentifier:12217748] PDB:9CQM [DatabaseIdentifier:12217820] PDB:3S65 [DatabaseIdentifier:12217798] PDB:7PCH [DatabaseIdentifier:12217774] PDB:6XE7 [DatabaseIdentifier:12217771] PDB:1J7Y [DatabaseIdentifier:12149448] PDB:8XMQ [DatabaseIdentifier:12217772] PDB:1O1N [DatabaseIdentifier:12217795] PDB:7AEV [DatabaseIdentifier:12217788] PDB:1Y4V [DatabaseIdentifier:12217744] PDB:9CQV [DatabaseIdentifier:12217760] PDB:4ROL [DatabaseIdentifier:12217757] PDB:1HDB [DatabaseIdentifier:12217791] PDB:2HBC [DatabaseIdentifier:12217712] PDB:1Y2Z [DatabaseIdentifier:12217652] PDB:3D17 [DatabaseIdentifier:12217662] PDB:1SDK [DatabaseIdentifier:12217718] PDB:1MKO [DatabaseIdentifier:12217733] PDB:9CQW [DatabaseIdentifier:12217644] PDB:6DI4 [DatabaseIdentifier:12217642] PDB:5VMM [DatabaseIdentifier:12217711] PDB:1HBA [DatabaseIdentifier:12217708] PDB:1Y22 [DatabaseIdentifier:12217687] PDB:5X2S [DatabaseIdentifier:12217656] PDB:1LFZ [DatabaseIdentifier:12217703] PDB:1J3Z [DatabaseIdentifier:12217685] PDB:5X2T [DatabaseIdentifier:12217681] PDB:1Y0W [DatabaseIdentifier:12217699] PDB:1ABY [DatabaseIdentifier:12235248] PDB:1CH4 [DatabaseIdentifier:12217661] PDB:1R1Y [DatabaseIdentifier:12217688] PDB:5X2U [DatabaseIdentifier:12217675] PDB:4MQH [DatabaseIdentifier:12217732] PDB:1YDZ [DatabaseIdentifier:12217719] PDB:6KYE [DatabaseIdentifier:12217715] PDB:7DY4 [DatabaseIdentifier:12217674] PDB:2M6Z [DatabaseIdentifier:12217669] PDB:4IJ2 [DatabaseIdentifier:12217678] PDB:4MQC [DatabaseIdentifier:12217716] PDB:6BWU [DatabaseIdentifier:12217649] PDB:1Y0C [DatabaseIdentifier:12217682] PDB:4FC3 [DatabaseIdentifier:12217730] PDB:6NQ5 [DatabaseIdentifier:12217641] PDB:3HHB [DatabaseIdentifier:12217702] PDB:4HHB [DatabaseIdentifier:12217690] PDB:1QSI [DatabaseIdentifier:12217665] PDB:1J40 [DatabaseIdentifier:12217670] PDB:1DXV [DatabaseIdentifier:12217696] PDB:1FN3 [DatabaseIdentifier:12217663] PDB:1R1X [DatabaseIdentifier:12217726] PDB:1Y4B [DatabaseIdentifier:12217697] PDB:1HAC [DatabaseIdentifier:12217676] PDB:4MQI [DatabaseIdentifier:12217705] PDB:2D60 [DatabaseIdentifier:12217735] PDB:1Y4F [DatabaseIdentifier:12217643] PDB:1KD2 [DatabaseIdentifier:12217684] PDB:1Y0T [DatabaseIdentifier:12217668] PDB:1UIW [DatabaseIdentifier:12217725] PDB:6HBW [DatabaseIdentifier:12217653] PDB:1LFQ [DatabaseIdentifier:12217704] PDB:7K4M [DatabaseIdentifier:12235247] PDB:8WXZ [DatabaseIdentifier:12217679] PDB:4MQG [DatabaseIdentifier:12217695] PDB:1C7B [DatabaseIdentifier:12217680] PDB:1DXT [DatabaseIdentifier:12217701] PDB:1ABW [DatabaseIdentifier:12217686] PDB:1IRD [DatabaseIdentifier:12217722] PDB:6BWP [DatabaseIdentifier:12217655] PDB:1LFL [DatabaseIdentifier:12217693] PDB:1C7D [DatabaseIdentifier:12217664] PDB:1J41 [DatabaseIdentifier:12217666] PDB:1M9P [DatabaseIdentifier:12217660] PDB:1LFT [DatabaseIdentifier:12217654] PDB:9AYZ [DatabaseIdentifier:12217639] PDB:7UF6 [DatabaseIdentifier:12217667] PDB:6HAL [DatabaseIdentifier:12217724] PDB:7DY3 [DatabaseIdentifier:12217648] PDB:1Y0D [DatabaseIdentifier:12217729] PDB:1YE0 [DatabaseIdentifier:12217717] PDB:8EGI [DatabaseIdentifier:12217698] PDB:1HAB [DatabaseIdentifier:12217692] PDB:1BUW [DatabaseIdentifier:12217694] PDB:1C7C [DatabaseIdentifier:12195848] PDB:5HU6 [DatabaseIdentifier:12217714] PDB:1Y31 [DatabaseIdentifier:12145638] PDB:3W4U [DatabaseIdentifier:12217658] PDB:1LFV [DatabaseIdentifier:12217659] PDB:1SDL [DatabaseIdentifier:12217731] PDB:3DUT [DatabaseIdentifier:12217709] PDB:8WJ0 [DatabaseIdentifier:12217734] PDB:1Y4G [DatabaseIdentifier:12217723] PDB:1Y35 [DatabaseIdentifier:12217683] PDB:5X2R [DatabaseIdentifier:12217672] PDB:1DXU [DatabaseIdentifier:12217707] PDB:8WJ2 [DatabaseIdentifier:12217645] PDB:1A0U [DatabaseIdentifier:12217728] PDB:1YE1 [DatabaseIdentifier:12217721] PDB:1A3N [DatabaseIdentifier:12217720] PDB:1A3O [DatabaseIdentifier:12217691] PDB:1QSH [DatabaseIdentifier:12217710] PDB:1HBB [DatabaseIdentifier:12217650] PDB:1A0Z [DatabaseIdentifier:12217677] PDB:1THB [DatabaseIdentifier:12217673] PDB:1J3Y [DatabaseIdentifier:12217671] PDB:7CUE [DatabaseIdentifier:12217651] PDB:1Y0A [DatabaseIdentifier:12217657] PDB:1LFY [DatabaseIdentifier:12217727] PDB:1YE2 [DatabaseIdentifier:12217706] PDB:8WJ1 [DatabaseIdentifier:12217647] PDB:1Y09 [DatabaseIdentifier:12217640] PDB:7UF7 [DatabaseIdentifier:12217713] PDB:8VYL [DatabaseIdentifier:12217689] PDB:2D5Z [DatabaseIdentifier:12217700] PDB:3WHM [DatabaseIdentifier:12217613] PDB:6L5Y [DatabaseIdentifier:12217621] PDB:8FDK [DatabaseIdentifier:12217631] PDB:1GLI [DatabaseIdentifier:12217616] PDB:3KMF [DatabaseIdentifier:12217622] PDB:3ODQ [DatabaseIdentifier:12217638] PDB:3HXN [DatabaseIdentifier:12217624] PDB:1RQ4 [DatabaseIdentifier:12217623] PDB:1RPS [DatabaseIdentifier:12217632] PDB:1A01 [DatabaseIdentifier:12217637] PDB:7UVB [DatabaseIdentifier:12217629] PDB:3QJD [DatabaseIdentifier:12217628] PDB:2W6V [DatabaseIdentifier:12217630] PDB:3QJE [DatabaseIdentifier:12217614] PDB:1BAB [DatabaseIdentifier:12217612] PDB:5WOG [DatabaseIdentifier:12217635] PDB:3QJB [DatabaseIdentifier:12217636] PDB:3QJC [DatabaseIdentifier:12217611] PDB:8FDN [DatabaseIdentifier:12217634] PDB:1A00 [DatabaseIdentifier:12217633] PDB:1BBB [DatabaseIdentifier:12217619] PDB:8FDM [DatabaseIdentifier:12217610] PDB:5WOH [DatabaseIdentifier:12217609] PDB:6L5W [DatabaseIdentifier:12217625] PDB:1RQ3 [DatabaseIdentifier:12217618] PDB:8FDL [DatabaseIdentifier:12217626] PDB:2W72 [DatabaseIdentifier:12217627] PDB:5JDO [DatabaseIdentifier:12217617] PDB:1NIH [DatabaseIdentifier:12217620] PDB:6L5V [DatabaseIdentifier:12217615] PDB:1RQA [DatabaseIdentifier:12217608] PDB:6L5X [DatabaseIdentifier:12138047] Orphanet:HBB [DatabaseIdentifier:12134642] OpenTargets:ENSG00000244734 [DatabaseIdentifier:11849940] HPA:ENSG00000244734-HBB [DatabaseIdentifier:11834333] HMDB Protein:HMDBP01625 [DatabaseIdentifier:11812804] GlyGen:P68871 [DatabaseIdentifier:11464722] ENSEMBL:ENSG00000244734 [DatabaseIdentifier:11559804] ENSEMBL:ENSP00000333994 [DatabaseIdentifier:11559803] ENSEMBL:ENSP00000494175 [DatabaseIdentifier:11682503] ENSEMBL:ENST00000647020 [DatabaseIdentifier:11682502] ENSEMBL:ENST00000335295
databaseName	UniProt
dbId	231538
description	recommendedName: Hemoglobin subunit beta alternativeName: Beta-globin alternativeName: Hemoglobin beta chain component recommendedName: LVV-hemorphin-7 /component component recommendedName: Spinorphin /component
displayName	UniProt:P68871 HBB
geneName	HBB
identifier	P68871
isSequenceChanged	false
keyword	3D-structure Acetylation Congenital dyserythropoietic anemia Direct protein sequencing Disease variant Glycation Glycoprotein Heme Hereditary hemolytic anemia Hypotensive agent Iron Metal-binding Oxygen transport Phosphoprotein Proteomics identification Pyruvate Reference proteome S-nitrosylation Transport Vasoactive
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	HBB
otherIdentifier	11715347_s_at 11715348_x_at 11753712_x_at 1562981_PM_at 1562981_at 16734840 209116_PM_x_at 209116_x_at 211696_PM_x_at 211696_x_at 217232_PM_x_at 217232_x_at 3043 31687_f_at 32052_at 3360402 3360403 3360404 3360405 3360406 3360407 3360408 3360409 3360410 3360411 3360412 3360413 3360414 3360422 7946033 A_23_P203558 A_33_P3289150 GE61327 GO:0003013 GO:0003014 GO:0004601 GO:0005344 GO:0005515 GO:0005576 GO:0005615 GO:0005829 GO:0005833 GO:0006954 GO:0008217 GO:0015670 GO:0015671 GO:0016491 GO:0019825 GO:0020037 GO:0030185 GO:0030492 GO:0031720 GO:0031721 GO:0031838 GO:0042542 GO:0042744 GO:0045429 GO:0046872 GO:0048821 GO:0048856 GO:0070062 GO:0070293 GO:0070527 GO:0071682 GO:0072562 GO:0097746 GO:0098754 GO:0098869 GO:0140104 GO:1904724 GO:1904813 HMNXSV003004371 HMNXSV003017647 Hs.155376.1.A1_3p_s_at ILMN_2100437 M25079_s_at PH_hs_0029250 PH_hs_0031887 TC11001330.hg TC11003023.hg U01317_cds6_at g13549111_3p_at g179408_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9625193] HBB [lysosomal lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1008196] HBB [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9631108] HBB [late endosome lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800191] HBB [tertiary granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2168872] HBB [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6801015] HBB [ficolin-1-rich granule lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2230936] HBB [endocytic vesicle lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1237013] CO-H+-HBB [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000244734] ENSEMBL:ENSG00000244734 HBB [ReferenceDNASequence:12733969] UCSC:P68871 HBB [ReferenceDNASequence:12118799] OMIM:141900 HBB [ReferenceDNASequence:12042854] NCBI Gene:3043 HBB [ReferenceDNASequence:11958761] Monarch:3043 HBB [ReferenceDNASequence:11871091] KEGG:hsa:3043 HBB [ReferenceDNASequence:11828689] HGNC:4827 HBB [ReferenceDNASequence:11328972] BioGPS Gene:3043 HBB [ReferenceDNASequence:11398927] COSMIC - genes:HBB HBB [ReferenceDNASequence:11426358] CTD Gene:3043 HBB [ReferenceDNASequence:11435820] dbSNP Gene:3043 HBB
referenceTranscript	[ReferenceRNASequence:12532133] RefSeq:NM_000518.5 HBB
schemaClass	ReferenceGeneProduct
secondaryIdentifier	HBB_HUMAN A4GX73 B2ZUE0 P02023 Q13852 Q14481 Q14510 Q45KT0 Q549N7 Q6FI08 Q6R7N2 Q8IZI1 Q9BX96 Q9UCD6 Q9UCP8 Q9UCP9
sequenceLength	147
species	[Species:48887] Homo sapiens
stId	uniprot:P68871
url	http://purl.uniprot.org/uniprot/P68871

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-9625193] HBB [lysosomal lumen] [EntityWithAccessionedSequence:R-HSA-1008196] HBB [cytosol] [EntityWithAccessionedSequence:R-HSA-9631108] HBB [late endosome lumen] [EntityWithAccessionedSequence:R-HSA-6800191] HBB [tertiary granule lumen] [EntityWithAccessionedSequence:R-HSA-2168872] HBB [extracellular region] [EntityWithAccessionedSequence:R-HSA-6801015] HBB [ficolin-1-rich granule lumen] [EntityWithAccessionedSequence:R-HSA-2230936] HBB [endocytic vesicle lumen] [EntityWithAccessionedSequence:R-HSA-1237013] CO-H+-HBB [cytosol]
(referenceSequence)	[ModifiedResidue:1237031] carboxylated residue at 2 [ModifiedResidue:1237019] protonated residue at unknown position
(interactor)	[UndirectedInteraction:11174625] UniProt:Q16659 <-> UniProt:P68871 (IntAct) [UndirectedInteraction:11200555] UniProt:P68871 <-> UniProt:P69905 (IntAct) [UndirectedInteraction:11200557] UniProt:P68871 <-> UniProt:P02008 (IntAct) [UndirectedInteraction:11200561] UniProt:P68871 <-> UniProt:Q9ULK0 (IntAct) [UndirectedInteraction:11200563] UniProt:P68871 <-> UniProt:Q6B0K9 (IntAct) [UndirectedInteraction:11200565] UniProt:P68871 <-> UniProt:P09105 (IntAct) [UndirectedInteraction:11200567] UniProt:P68871 <-> UniProt:Q6DKK2 (IntAct) [UndirectedInteraction:11200569] UniProt:P68871 <-> UniProt:P20933 (IntAct) [UndirectedInteraction:11200571] UniProt:P68871 <-> UniProt:Q9UNS2 (IntAct) [UndirectedInteraction:11200575] UniProt:P68871 <-> UniProt:Q02383 (IntAct) [UndirectedInteraction:11200577] UniProt:P68871 <-> UniProt:A2RU67 (IntAct) [UndirectedInteraction:11200579] UniProt:P68871 <-> UniProt:P27348 (IntAct) [UndirectedInteraction:11200581] UniProt:P68871 <-> UniProt:P62195 (IntAct) [UndirectedInteraction:11200583] UniProt:P68871 <-> UniProt:Q96T60 (IntAct) [UndirectedInteraction:11200585] UniProt:P68871 <-> UniProt:Q9HBW0 (IntAct) [UndirectedInteraction:11200587] UniProt:P68871 <-> UniProt:P11142 (IntAct) [UndirectedInteraction:11200589] UniProt:P68871 <-> UniProt:Q6UXU6 (IntAct) [UndirectedInteraction:11200591] UniProt:P68871 <-> UniProt:P06899 (IntAct) [UndirectedInteraction:11200595] UniProt:P68871 <-> UniProt:Q9NXJ5 (IntAct) [UndirectedInteraction:11200597] UniProt:P68871 <-> UniProt:Q5TEU4 (IntAct) [UndirectedInteraction:11200601] UniProt:P68871 <-> UniProt:P22003 (IntAct) [UndirectedInteraction:11200603] UniProt:P68871 <-> UniProt:P30711 (IntAct) [UndirectedInteraction:11200605] UniProt:P68871 <-> UniProt:O15151 (IntAct) [UndirectedInteraction:11200607] UniProt:P68871 <-> UniProt:Q8TAC2 (IntAct) [UndirectedInteraction:11200609] UniProt:P68871 <-> UniProt:O60759 (IntAct) [UndirectedInteraction:11200611] UniProt:P68871 <-> UniProt:Q9HCI7 (IntAct)

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