UniProt:P63172 DYNLT1

chain
  • chain:1-113
checksum A6BAD1D0744D1AA6
comment
  • FUNCTION Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia.FUNCTION Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (PubMed:27502274).FUNCTION (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site.SUBUNIT Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Part of the ciliary outer dynein arms (ODAs), at least consisting of dynein axonemal heavy chains, light chains and intermediate chains (By similarity). The ODAs interact with DNAAF9; this interaction inactivates the dyneins (By similarity). Interacts with DYNC1I1 and DYNC1I2. Interacts with RHO. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with BMPR2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide-binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma (By similarity). Interacts with ACVR2B and ARHGEF2. Interacts with DNAI4 (By similarity). Interacts with CFAP61 (By similarity).SUBUNIT (Microbial infection) Interacts with human papillomavirus 16 L2 protein; this interaction is essential for virus intracellular transport during entry.SUBUNIT (Microbial infection) Interacts with Mason-Pfizer monkey virus protein Gag.INTERACTION Localizes to mitotic spindles.TISSUE SPECIFICITY Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).PTM Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIM:178600]. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity).SIMILARITY Belongs to the dynein light chain Tctex-type family.
crossReference
databaseName UniProt
dbId 54028
description
  • recommendedName: Dynein light chain Tctex-type 1 alternativeName: Protein CW-1 alternativeName: T-complex testis-specific protein 1 homolog
displayName UniProt:P63172 DYNLT1
geneName
  • DYNLT1
  • TCTEL1
  • TCTEX-1
  • TCTEX1
identifier P63172
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cell cycle
  • Cell division
  • Cytoplasm
  • Cytoplasmic inwards viral transport
  • Cytoskeleton
  • Dynein
  • Golgi apparatus
  • Host-virus interaction
  • Microtubular inwards viral transport
  • Microtubule
  • Mitosis
  • Motor protein
  • Neurogenesis
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transport
  • Virus entry into host cell
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • DYNLT1
otherIdentifier
  • 11716583_a_at
  • 11716584_x_at
  • 11753785_x_at
  • 17025177
  • 201999_PM_s_at
  • 201999_s_at
  • 2981875
  • 2981876
  • 2981877
  • 2981878
  • 2981879
  • 2981880
  • 2981881
  • 2981882
  • 2981885
  • 2981886
  • 2981889
  • 2981890
  • 3710718
  • 6993
  • 8130499
  • 946_at
  • A_23_P8185
  • A_33_P3260445
  • D50663_at
  • GE61149
  • GO:0000132
  • GO:0005515
  • GO:0005576
  • GO:0005737
  • GO:0005794
  • GO:0005819
  • GO:0005856
  • GO:0005868
  • GO:0005874
  • GO:0005881
  • GO:0007010
  • GO:0007018
  • GO:0007399
  • GO:0008277
  • GO:0019060
  • GO:0030286
  • GO:0032388
  • GO:0034774
  • GO:0042802
  • GO:0043226
  • GO:0043657
  • GO:0045505
  • GO:0046718
  • GO:0048856
  • GO:0050768
  • GO:0051301
  • GO:0075521
  • GO:0075606
  • GO:0099503
  • GO:1904813
  • HMNXSV003011447
  • HMNXSV003016472
  • ILMN_1678766
  • PH_hs_0013701
  • TC06002263.hg
  • g5730084_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DYLT1_HUMAN
  • Q15763
  • Q5VTU4
sequenceLength 113
species [Species:48887] Homo sapiens
stId uniprot:P63172
url http://purl.uniprot.org/uniprot/P63172

Referrals

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