Reactome | UniProt:P63104 YWHAZ

chain	chain:1-245
checksum	D464DF2286BBFE60
comment	FUNCTION Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).SUBUNIT Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1 (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity). Homodimer (PubMed:12865427, PubMed:16376338). Heterodimerizes with YWHAE (PubMed:16376338). Homo- and heterodimerization is inhibited by phosphorylation on Ser-58 (PubMed:16376338). Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232 (PubMed:31024343). Interacts with BRAF (PubMed:31024343). Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity). Interacts with SLITRK1 (PubMed:19640509). Interacts with AK5, LDB1, MADD, MARK3, PDE1A and SMARCB1 (PubMed:16959763). Interacts with MEFV (PubMed:27030597). Interacts with ADAM22 (via C-terminus) (PubMed:12589811).SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus protein BPLF1 and TRIM25; leading to inhibition of the type-I IFN response.INTERACTION Located to stage I to stage IV melanosomes.ALTERNATIVE PRODUCTS The delta, brain-specific form differs from the zeta form in being phosphorylated (Probable). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria (PubMed:15071501, PubMed:15696159). Phosphorylation on Thr-232; inhibits binding of RAF1 (PubMed:9360956). Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (PubMed:11956222, PubMed:12865427, PubMed:15883165, PubMed:16376338). Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53 (PubMed:11956222, PubMed:12865427, PubMed:15883165, PubMed:16376338).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the 14-3-3 family.CAUTION Was originally thought to have phospholipase A2 activity.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.
crossReference	[DatabaseIdentifier:11447011] ENSEMBL:ENSG00000164924 [DatabaseIdentifier:12314293] RefSeq:XP_016869299.1 [DatabaseIdentifier:12314301] RefSeq:NP_001129174.1 [DatabaseIdentifier:12314299] RefSeq:NP_001129171.1 [DatabaseIdentifier:12314298] RefSeq:NP_001129172.1 [DatabaseIdentifier:12314302] RefSeq:XP_016869300.1 [DatabaseIdentifier:12314297] RefSeq:XP_054217160.1 [DatabaseIdentifier:12314290] RefSeq:XP_005251118.1 [DatabaseIdentifier:12314291] RefSeq:XP_054217159.1 [DatabaseIdentifier:12314294] RefSeq:XP_005251120.1 [DatabaseIdentifier:12314295] RefSeq:XP_054217157.1 [DatabaseIdentifier:12314303] RefSeq:NP_001129173.1 [DatabaseIdentifier:12314300] RefSeq:NP_663723.1 [DatabaseIdentifier:12314296] RefSeq:XP_054217158.1 [DatabaseIdentifier:12314292] RefSeq:NP_003397.1 [DatabaseIdentifier:12282951] Pharos - Targets:P63104 [DatabaseIdentifier:12241138] PRO:P63104 [DatabaseIdentifier:12163229] PDB:4ZDR [DatabaseIdentifier:12163259] PDB:6YO8 [DatabaseIdentifier:12163253] PDB:1IB1 [DatabaseIdentifier:12163230] PDB:3NKX [DatabaseIdentifier:12148849] PDB:6U2H [DatabaseIdentifier:12148817] PDB:7MFD [DatabaseIdentifier:12163241] PDB:2C1N [DatabaseIdentifier:12163257] PDB:4HKC [DatabaseIdentifier:12154476] PDB:6EJL [DatabaseIdentifier:12163252] PDB:1QJB [DatabaseIdentifier:12163254] PDB:7D9V [DatabaseIdentifier:12148887] PDB:8VYP [DatabaseIdentifier:12163263] PDB:9UJ2 [DatabaseIdentifier:12163228] PDB:8AH2 [DatabaseIdentifier:12163256] PDB:6RLZ [DatabaseIdentifier:12163240] PDB:5D2D [DatabaseIdentifier:12163224] PDB:5WXN [DatabaseIdentifier:12148878] PDB:8VYV [DatabaseIdentifier:12163250] PDB:3CU8 [DatabaseIdentifier:12163235] PDB:6F09 [DatabaseIdentifier:12163233] PDB:6ZFD [DatabaseIdentifier:12163245] PDB:2C1J [DatabaseIdentifier:12148884] PDB:8VYR [DatabaseIdentifier:12163244] PDB:6YMO [DatabaseIdentifier:12163248] PDB:6FN9 [DatabaseIdentifier:12148822] PDB:7MFE [DatabaseIdentifier:12149932] PDB:4WRQ [DatabaseIdentifier:12163242] PDB:5ULO [DatabaseIdentifier:12163247] PDB:1QJA [DatabaseIdentifier:12163239] PDB:5J31 [DatabaseIdentifier:12163258] PDB:7ZIT [DatabaseIdentifier:12163236] PDB:4IHL [DatabaseIdentifier:12163262] PDB:5D3F [DatabaseIdentifier:12163238] PDB:4BG6 [DatabaseIdentifier:12148879] PDB:8VYS [DatabaseIdentifier:12163249] PDB:5JM4 [DatabaseIdentifier:12148821] PDB:6Q0K [DatabaseIdentifier:12163260] PDB:6EWW [DatabaseIdentifier:12163223] PDB:9FUM [DatabaseIdentifier:12163261] PDB:8WE2 [DatabaseIdentifier:12163246] PDB:7D8P [DatabaseIdentifier:12148885] PDB:8VYO [DatabaseIdentifier:12163243] PDB:3RDH [DatabaseIdentifier:12148880] PDB:8VYW [DatabaseIdentifier:12163234] PDB:6ZFG [DatabaseIdentifier:12163226] PDB:6EF5 [DatabaseIdentifier:12163255] PDB:8QDV [DatabaseIdentifier:12163237] PDB:6F08 [DatabaseIdentifier:12148877] PDB:8VYU [DatabaseIdentifier:12148815] PDB:7MFF [DatabaseIdentifier:12163225] PDB:4FJ3 [DatabaseIdentifier:12163232] PDB:9FVL [DatabaseIdentifier:12148882] PDB:8VYQ [DatabaseIdentifier:12163231] PDB:5NAS [DatabaseIdentifier:12163251] PDB:8A9G [DatabaseIdentifier:12163227] PDB:7D8H [DatabaseIdentifier:12163212] PDB:2O02 [DatabaseIdentifier:12163211] PDB:7Q16 [DatabaseIdentifier:12163222] PDB:6YOS [DatabaseIdentifier:12163217] PDB:8WF6 [DatabaseIdentifier:12163220] PDB:6FNC [DatabaseIdentifier:12163215] PDB:4N7G [DatabaseIdentifier:12163219] PDB:6FNA [DatabaseIdentifier:12163208] PDB:5M35 [DatabaseIdentifier:12163210] PDB:5M37 [DatabaseIdentifier:12163209] PDB:4N7Y [DatabaseIdentifier:12163214] PDB:4N84 [DatabaseIdentifier:12163213] PDB:5EWZ [DatabaseIdentifier:12163216] PDB:2WH0 [DatabaseIdentifier:12163221] PDB:6FNB [DatabaseIdentifier:12163218] PDB:5XY9 [DatabaseIdentifier:12163207] PDB:5M36 [DatabaseIdentifier:12148867] PDB:6XAG [DatabaseIdentifier:12163206] PDB:5EXA [DatabaseIdentifier:12122631] OpenTargets:ENSG00000164924 [DatabaseIdentifier:11838127] HPA:ENSG00000164924-YWHAZ [DatabaseIdentifier:11833143] HMDB Protein:HMDBP02552 [DatabaseIdentifier:11800592] GlyGen:P63104 [DatabaseIdentifier:11785040] GeneCards:YWHAZ [DatabaseIdentifier:11657390] ENSEMBL:ENST00000395956 [DatabaseIdentifier:11657388] ENSEMBL:ENST00000353245 [DatabaseIdentifier:11657382] ENSEMBL:ENST00000522542 [DatabaseIdentifier:11657384] ENSEMBL:ENST00000457309 [DatabaseIdentifier:11657387] ENSEMBL:ENST00000395957 [DatabaseIdentifier:11657386] ENSEMBL:ENST00000419477 [DatabaseIdentifier:11657389] ENSEMBL:ENST00000395958 [DatabaseIdentifier:11657383] ENSEMBL:ENST00000395953 [DatabaseIdentifier:11657385] ENSEMBL:ENST00000395951 [DatabaseIdentifier:11534690] ENSEMBL:ENSP00000379281 [DatabaseIdentifier:11534684] ENSEMBL:ENSP00000398599 [DatabaseIdentifier:11534688] ENSEMBL:ENSP00000379287 [DatabaseIdentifier:11534687] ENSEMBL:ENSP00000379288 [DatabaseIdentifier:11534683] ENSEMBL:ENSP00000430072 [DatabaseIdentifier:11534686] ENSEMBL:ENSP00000379286 [DatabaseIdentifier:11534685] ENSEMBL:ENSP00000395114 [DatabaseIdentifier:11534689] ENSEMBL:ENSP00000309503 [DatabaseIdentifier:11534691] ENSEMBL:ENSP00000379283
databaseName	UniProt
dbId	48917
description	recommendedName: 14-3-3 protein zeta/delta alternativeName: Protein kinase C inhibitor protein 1 shortName: KCIP-1
displayName	UniProt:P63104 YWHAZ
geneName	YWHAZ
identifier	P63104
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant Host-virus interaction Intellectual disability Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	YWHAZ
otherIdentifier	11756181_x_at 11758667_x_at 11758711_x_at 11758750_x_at 11758751_at 11758752_x_at 1235_at 1556496_PM_a_at 1556496_a_at 17079711 17120418 200638_PM_s_at 200638_s_at 200639_PM_s_at 200639_s_at 200640_PM_at 200640_at 200641_PM_s_at 200641_s_at 214848_PM_at 214848_at 2574516 2574517 2924960 3146891 3146893 3146895 3146897 3146899 3146900 3146901 3146902 3146903 3146904 3146905 3146906 3146907 3146908 3146909 3146910 3146911 3146912 3146913 3146919 3146921 3146929 3146930 3146931 3146932 3146933 3146934 3146935 3146936 3146937 3146938 3146939 3146940 3146941 3146942 3146943 3146944 3146945 3146946 3146947 3146948 3146949 3146950 3146951 3146952 3146953 3146954 3146955 3204097 3204098 3238808 3238818 3238820 3262898 34642_at 36760_at 3694476 3749823 4005925 4005976 55272_at 7534 8152096 A_19_P00802601 A_24_P209571 A_24_P532478 GE548889 GE58115 GE59443 GE80033 GO:0000122 GO:0001525 GO:0003016 GO:0003723 GO:0004497 GO:0005515 GO:0005615 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005925 GO:0006355 GO:0006468 GO:0006605 GO:0007040 GO:0007165 GO:0008039 GO:0008104 GO:0016301 GO:0016491 GO:0019901 GO:0019903 GO:0019904 GO:0030324 GO:0031625 GO:0031647 GO:0031669 GO:0031982 GO:0035148 GO:0038202 GO:0042149 GO:0042470 GO:0042802 GO:0043066 GO:0043067 GO:0043226 GO:0044325 GO:0045296 GO:0045824 GO:0048856 GO:0050815 GO:0051683 GO:0070062 GO:0070371 GO:0070372 GO:0072562 GO:0090128 GO:0090168 GO:0098686 GO:0098978 GO:0140297 GO:0140311 GO:0140367 GO:1900181 GO:1904262 GO:1905671 HMNXSV003006124 HMNXSV003052498 Hs.71848.0.S1_3p_at Hs2.58429.1.S1_3p_s_at ILMN_1669286 ILMN_1801928 M86400_at PH_hs_0040263 TC08001485.hg TC08002448.hg TC08002449.hg TC08002451.hg TC10000164.hg U79277_at g13177678_3p_a_at g4507952_3p_a_at g899458_3p_a_at p15857
physicalEntity	[EntityWithAccessionedSequence:R-HSA-206099] YWHAZ [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-450469] YWHAZ [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000164924] ENSEMBL:ENSG00000164924 YWHAZ [ReferenceDNASequence:12671189] UCSC:P63104 YWHAZ [ReferenceDNASequence:12108226] OMIM:601288 YWHAZ [ReferenceDNASequence:12026462] NCBI Gene:7534 YWHAZ [ReferenceDNASequence:11942369] Monarch:7534 YWHAZ [ReferenceDNASequence:11856148] KEGG:hsa:7534 YWHAZ [ReferenceDNASequence:11816665] HGNC:12855 YWHAZ [ReferenceDNASequence:11426837] dbSNP Gene:7534 YWHAZ [ReferenceDNASequence:11409341] CTD Gene:7534 YWHAZ [ReferenceDNASequence:11391237] COSMIC - genes:YWHAZ YWHAZ [ReferenceDNASequence:11312580] BioGPS Gene:7534 YWHAZ
referenceTranscript	[ReferenceRNASequence:12496369] RefSeq:XM_054361185.1 YWHAZ [ReferenceRNASequence:12496367] RefSeq:XM_005251061.4 YWHAZ [ReferenceRNASequence:12496365] RefSeq:XM_017013810.3 YWHAZ [ReferenceRNASequence:12496374] RefSeq:NM_001135699.2 YWHAZ [ReferenceRNASequence:12496361] RefSeq:XM_054361182.1 YWHAZ [ReferenceRNASequence:12496362] RefSeq:XM_054361184.1 YWHAZ [ReferenceRNASequence:12496372] RefSeq:NM_001135702.2 YWHAZ [ReferenceRNASequence:12496363] RefSeq:XM_054361183.1 YWHAZ [ReferenceRNASequence:12496366] RefSeq:XM_017013811.2 YWHAZ [ReferenceRNASequence:12496371] RefSeq:XM_005251063.4 YWHAZ [ReferenceRNASequence:12496370] RefSeq:NM_001135701.2 YWHAZ [ReferenceRNASequence:12496373] RefSeq:NM_001135700.2 YWHAZ [ReferenceRNASequence:12496368] RefSeq:NM_145690.3 YWHAZ [ReferenceRNASequence:12496364] RefSeq:NM_003406.4 YWHAZ
schemaClass	ReferenceGeneProduct
secondaryIdentifier	1433Z_HUMAN A8K1N0 B7Z465 P29213 P29312 Q32P43 Q5XJ08 Q6GPI2 Q6IN74 Q6NUR9 Q6P3U9 Q86V33
sequenceLength	245
species	[Species:48887] Homo sapiens
stId	uniprot:P63104
url	http://purl.uniprot.org/uniprot/P63104

UniProt:P63104 YWHAZ Show undefined attributes

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