UniProt:P63002 Tle5

chain
  • chain:1-197
checksum 2C00233AA6921A9F
comment
  • FUNCTION Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.SUBUNIT Homooligomer and heterooligomer with other family members. Binds TCF7 and the NF-kappa-B subunit RELA. Interacts with PHF12 (By similarity). Interacts (via Q domain) with SIX3. Interacts with SIX6.INTERACTION Ubiquitously expressed in developing embryos by midgestation, a wide expression is conserved in adult. In mouse, abundantly expressed in muscle, heart and brain.DEVELOPMENTAL STAGE Expressed in the developing eye and forebrain of embryos.DOMAIN Lacks the C-terminal WD repeats.PTM Ubiquitinated by XIAP/BIRC4.SIMILARITY Belongs to the WD repeat Groucho/TLE family.
created [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
crossReference
databaseName UniProt
dbId 91639
description
  • recommendedName: fullName evidence="9"TLE family member 5 alternativeName: Amino-terminal enhancer of split shortName: Amino enhancer of split alternativeName: Grg-5 alternativeName: Groucho-related protein 5 alternativeName: Protein ESP1 alternativeName: Protein GRG
displayName UniProt:P63002 Tle5
geneName
  • Tle5
  • Aes
  • Esp1
  • Grg
  • Grg5
identifier P63002
isSequenceChanged false
keyword
  • Alternative splicing
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • Wnt signaling pathway
modified [InstanceEdit:9862192] Weiser, Joel, 2024-02-26
moleculeType Protein
name
  • Tle5
otherIdentifier
  • 10365136
  • 1420619_a_at
  • 14797
  • 160215_at
  • 17235748
  • 4448225
  • 4506595
  • 4519411
  • 4539966
  • 4651723
  • 4700580
  • 4936293
  • 4958503
  • 4974931
  • 5114006
  • 5125650
  • 5236899
  • 5306304
  • 5319687
  • 5367356
  • 5392389
  • 5454561
  • 5489244
  • 5577339
  • 5594619
  • A_51_P243342
  • A_55_P1968285
  • A_55_P2043287
  • GE35498
  • GO:0000122
  • GO:0001501
  • GO:0003714
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0006355
  • GO:0006357
  • GO:0010629
  • GO:0016055
  • GO:0040008
  • GO:0045892
  • GO:0048856
  • GO:0060761
  • GO:0070555
  • GO:0090090
  • GO:2000210
  • ILMN_2808336
  • x73359_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TLE5_MOUSE
  • Q06195
sequenceLength 197
species [Species:48892] Mus musculus
stId uniprot:P63002
url http://purl.uniprot.org/uniprot/P63002
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