Reactome | UniProt:P62834 RAP1A

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UniProt:P62834 RAP1A Show undefined attributes

chain	chain:1-181 propeptide:182-184
checksum	42C39290C98E0A92
comment	FUNCTION Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (PubMed:17916086). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (PubMed:25208567). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)ACTIVITY REGULATION Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR.SUBUNIT Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A (PubMed:17916086). Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1 (PubMed:17916086). Found in a complex composed of CDH1, RAP1A and PKP3; PKP3 acts as a scaffold protein within the complex, the complex is required for CDH1 localization to mature desmosome cell junctions (PubMed:25208567). In its GTP-bound form interacts with PLCE1 and RADIL (PubMed:11022048, PubMed:12444546, PubMed:17704304). Interacts with SGSM1, SGSM2 and SGSM3 (PubMed:17509819). Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain) (PubMed:10608844, PubMed:11359771). Interacts with TBC1D21 (By similarity). Interacts with RAP1GDS1 (PubMed:20709748).INTERACTION Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region.SIMILARITY Belongs to the small GTPase superfamily. Ras family.
crossReference	[DatabaseIdentifier:12816102] ZINC target:P62834 [DatabaseIdentifier:12812724] ZINC - Substances:RAP1A_HUMAN [DatabaseIdentifier:12285598] Pharos - Targets:P62834 [DatabaseIdentifier:12264866] PRO:P62834 [DatabaseIdentifier:12178722] PDB:4KVG [DatabaseIdentifier:12178723] PDB:1GUA [DatabaseIdentifier:12178724] PDB:1C1Y [DatabaseIdentifier:12178725] PDB:3KUC [DatabaseIdentifier:12125293] OpenTargets:ENSG00000116473 [DatabaseIdentifier:11840751] HPA:ENSG00000116473-RAP1A [DatabaseIdentifier:11832078] HMDB Protein:HMDBP01963 [DatabaseIdentifier:11803157] GlyGen:P62834 [DatabaseIdentifier:11787678] GeneCards:RAP1A [DatabaseIdentifier:11692616] ENSEMBL:ENST00000369709 [DatabaseIdentifier:11692615] ENSEMBL:ENST00000687939 [DatabaseIdentifier:11692617] ENSEMBL:ENST00000356415 [DatabaseIdentifier:11569918] ENSEMBL:ENSP00000358723 [DatabaseIdentifier:11569917] ENSEMBL:ENSP00000509234 [DatabaseIdentifier:11569916] ENSEMBL:ENSP00000348786 [DatabaseIdentifier:11472319] ENSEMBL:ENSG00000116473
databaseName	UniProt
dbId	62704
description	recommendedName: Ras-related protein Rap-1A ecNumber evidence="2"3.6.5.2 alternativeName: C21KG alternativeName: G-22K alternativeName: GTP-binding protein smg p21A alternativeName: Ras-related protein Krev-1
displayName	UniProt:P62834 RAP1A
geneName	RAP1A KREV1
identifier	P62834
isSequenceChanged	false
keyword	3D-structure Cell junction Cell membrane Cytoplasm Direct protein sequencing Endosome GTP-binding Hydrolase Lipoprotein Membrane Methylation Neurogenesis Nucleotide-binding Prenylation Proteomics identification Reference proteome Tumor suppressor
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	RAP1A
otherIdentifier	11716097_a_at 11716098_a_at 11716099_s_at 16668712 1848_at 202362_PM_at 202362_at 228548_PM_at 228548_at 2351873 2351879 2351882 2351904 2351905 2351906 2351907 2351910 2351911 2351912 2351915 2351916 2351917 2351918 2351919 2351920 2351921 2351922 2351923 2351924 2351925 2922687 3544134 3544136 38756_at 45178_at 5906 70281_at 7903988 A_14_P128424 A_23_P51754 A_33_P3342285 GE61649 GE79260 GE86022 GE87982 GO:0000166 GO:0003924 GO:0003925 GO:0005085 GO:0005515 GO:0005525 GO:0005737 GO:0005768 GO:0005769 GO:0005770 GO:0005829 GO:0005886 GO:0007165 GO:0007264 GO:0007399 GO:0009743 GO:0010008 GO:0010976 GO:0012505 GO:0016020 GO:0016079 GO:0016192 GO:0016787 GO:0019003 GO:0030054 GO:0031267 GO:0031410 GO:0032045 GO:0032486 GO:0032966 GO:0035579 GO:0038180 GO:0043005 GO:0043547 GO:0044877 GO:0045335 GO:0045860 GO:0046326 GO:0048471 GO:0048856 GO:0050766 GO:0060369 GO:0061028 GO:0070062 GO:0070161 GO:0070374 GO:0071320 GO:0072659 GO:0097225 GO:0097327 GO:0097421 GO:0098696 GO:0098772 GO:0098793 GO:0098978 GO:1901888 GO:1904322 GO:1990090 GO:2000301 GO:2001214 HMNXSV003010206 Hs.306647.0.S1_3p_at ILMN_1766176 ILMN_1809191 M22995_at PH_hs_0027523 PH_hs_0036604 TC01000979.hg TC01004621.hg g4506412_3p_at p25691
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6806137] RAP1A [specific granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-169884] RAP1A [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-190053] RAP1A [endosome membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-354118] RAP1A [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12686767] UCSC:P62834 RAP1A [ReferenceDNASequence:12110621] OMIM:179520 RAP1A [ReferenceDNASequence:12051284] NCBI Gene:5906 RAP1A [ReferenceDNASequence:11967191] Monarch:5906 RAP1A [ReferenceDNASequence:11878410] KEGG:hsa:5906 RAP1A [ReferenceDNASequence:11819323] HGNC:9855 RAP1A [ReferenceDNASequence:11428490] dbSNP Gene:5906 RAP1A [ReferenceDNASequence:11413567] CTD Gene:5906 RAP1A [ReferenceDNASequence:11392655] COSMIC - genes:RAP1A RAP1A [ReferenceDNASequence:11337402] BioGPS Gene:5906 RAP1A [ReferenceDNASequence:ensembl:ENSG00000116473] ENSEMBL:ENSG00000116473 RAP1A
referenceTranscript	[ReferenceRNASequence:12550086] RefSeq:NM_001370217.2 RAP1A [ReferenceRNASequence:12550085] RefSeq:NM_002884.4 RAP1A [ReferenceRNASequence:12550082] RefSeq:NM_001010935.3 RAP1A [ReferenceRNASequence:12550084] RefSeq:NM_001394066.1 RAP1A [ReferenceRNASequence:12550083] RefSeq:NM_001291896.3 RAP1A [ReferenceRNASequence:12550087] RefSeq:NM_001370216.2 RAP1A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RAP1A_HUMAN P10113
sequenceLength	184
species	[Species:48887] Homo sapiens
stId	uniprot:P62834
url	http://purl.uniprot.org/uniprot/P62834

Referrals

(interactor)	[UndirectedInteraction:11252431] UniProt:Q8TAG9 <-> UniProt:P62834 (IntAct) [UndirectedInteraction:11235635] UniProt:P04049 <-> UniProt:P62834 (IntAct) [UndirectedInteraction:11199591] UniProt:P52306 <-> UniProt:P62834 (IntAct) [UndirectedInteraction:11197359] UniProt:Q92845 <-> UniProt:P62834 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6806137] RAP1A [specific granule membrane] [EntityWithAccessionedSequence:R-HSA-169884] RAP1A [cytosol] [EntityWithAccessionedSequence:R-HSA-190053] RAP1A [endosome membrane] [EntityWithAccessionedSequence:R-HSA-354118] RAP1A [plasma membrane]