Reactome | UniProt:P62314 SNRPD1

chain	chain:1-119
checksum	0C81C94BF98E0810
comment	FUNCTION Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (PubMed:23333303).SUBUNIT Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006, PubMed:36797247). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (PubMed:10025403, PubMed:19325628, PubMed:21113136, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). Component of the U1 snRNP (PubMed:19325628, PubMed:21113136, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:21113136, PubMed:25555158). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). Component of the minor spliceosome, which splices U12-type introns (PubMed:15146077, PubMed:33509932). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly (PubMed:16314521). Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts (via C-terminus) with SMN1 (via Tudor domain); the interaction is direct (PubMed:10500148, PubMed:11135666). Interacts with GEMIN2; the interaction is direct (PubMed:21816274). Interacts with SNRPD2; the interaction is direct (PubMed:21816274, PubMed:31799625).INTERACTION SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.PTM Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.MISCELLANEOUS In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.SIMILARITY Belongs to the snRNP core protein family.
crossReference	[DatabaseIdentifier:12141228] PDB:8RO2 [DatabaseIdentifier:12366381] RefSeq:NP_001278845.1 [DatabaseIdentifier:12366380] RefSeq:NP_008869.1 [DatabaseIdentifier:12285084] Pharos - Targets:P62314 [DatabaseIdentifier:12264024] PRO:P62314 [DatabaseIdentifier:12139760] PDB:3JCR [DatabaseIdentifier:12145807] PDB:8I0R [DatabaseIdentifier:12139749] PDB:6QX9 [DatabaseIdentifier:12141282] PDB:8Q7W [DatabaseIdentifier:12174482] PDB:9GC0 [DatabaseIdentifier:12174475] PDB:5XJR [DatabaseIdentifier:12174470] PDB:4WZJ [DatabaseIdentifier:12140526] PDB:7W5B [DatabaseIdentifier:12174480] PDB:4V98 [DatabaseIdentifier:12139761] PDB:8H6J [DatabaseIdentifier:12140524] PDB:6QDV [DatabaseIdentifier:12141231] PDB:5MQF [DatabaseIdentifier:12174486] PDB:9E3B [DatabaseIdentifier:12141285] PDB:8RC0 [DatabaseIdentifier:12155842] PDB:6Y5Q [DatabaseIdentifier:12139746] PDB:8QXD [DatabaseIdentifier:12139744] PDB:6AHD [DatabaseIdentifier:12145803] PDB:7QTT [DatabaseIdentifier:12140525] PDB:7W5A [DatabaseIdentifier:12139759] PDB:8H6L [DatabaseIdentifier:12174481] PDB:5XJL [DatabaseIdentifier:12139756] PDB:8RM5 [DatabaseIdentifier:12139755] PDB:8R08 [DatabaseIdentifier:12141232] PDB:6ID1 [DatabaseIdentifier:12145809] PDB:8I0S [DatabaseIdentifier:12139757] PDB:8QO9 [DatabaseIdentifier:12141283] PDB:8Q91 [DatabaseIdentifier:12145812] PDB:5Z56 [DatabaseIdentifier:12174483] PDB:4PJO [DatabaseIdentifier:12174477] PDB:5XJT [DatabaseIdentifier:12156143] PDB:7EVO [DatabaseIdentifier:12139754] PDB:8R0B [DatabaseIdentifier:12139747] PDB:8Y6O [DatabaseIdentifier:12174469] PDB:4F7U [DatabaseIdentifier:12155846] PDB:8Y7E [DatabaseIdentifier:12174473] PDB:3PGW [DatabaseIdentifier:12174472] PDB:3CW1 [DatabaseIdentifier:12164223] PDB:7B0Y [DatabaseIdentifier:12174474] PDB:1B34 [DatabaseIdentifier:12140527] PDB:7A5P [DatabaseIdentifier:12140529] PDB:9FMD [DatabaseIdentifier:12139735] PDB:8QZS [DatabaseIdentifier:12174479] PDB:5XJU [DatabaseIdentifier:12139070] PDB:8I0W [DatabaseIdentifier:12145810] PDB:8I0T [DatabaseIdentifier:12139733] PDB:6QW6 [DatabaseIdentifier:12141281] PDB:8Q7X [DatabaseIdentifier:12145802] PDB:6FF7 [DatabaseIdentifier:12148382] PDB:7DVQ [DatabaseIdentifier:12139661] PDB:8Q7V [DatabaseIdentifier:12139734] PDB:8H6E [DatabaseIdentifier:12139758] PDB:8R09 [DatabaseIdentifier:12148381] PDB:5Z58 [DatabaseIdentifier:12156139] PDB:7VPX [DatabaseIdentifier:12145811] PDB:5Z57 [DatabaseIdentifier:12139748] PDB:5O9Z [DatabaseIdentifier:12141229] PDB:8I0U [DatabaseIdentifier:12166593] PDB:8R7N [DatabaseIdentifier:12141230] PDB:8I0V [DatabaseIdentifier:12139071] PDB:5YZG [DatabaseIdentifier:12139750] PDB:6AH0 [DatabaseIdentifier:12140528] PDB:7W59 [DatabaseIdentifier:12142015] PDB:8HK1 [DatabaseIdentifier:12141227] PDB:6ID0 [DatabaseIdentifier:12166592] PDB:9GBW [DatabaseIdentifier:12174478] PDB:5XJS [DatabaseIdentifier:12145804] PDB:8CH6 [DatabaseIdentifier:12155847] PDB:6Y53 [DatabaseIdentifier:12142436] PDB:7ABG [DatabaseIdentifier:12174487] PDB:9E3C [DatabaseIdentifier:12139762] PDB:8H6K [DatabaseIdentifier:12174476] PDB:5XJQ [DatabaseIdentifier:12145806] PDB:7ABI [DatabaseIdentifier:12164245] PDB:9QEQ [DatabaseIdentifier:12139662] PDB:8Q7Q [DatabaseIdentifier:12140514] PDB:5XJC [DatabaseIdentifier:12140523] PDB:6ICZ [DatabaseIdentifier:12174471] PDB:9GCL [DatabaseIdentifier:12139751] PDB:8R0A [DatabaseIdentifier:11471495] ENSEMBL:ENSG00000167088 [DatabaseIdentifier:11568772] ENSEMBL:ENSP00000300413 [DatabaseIdentifier:11691471] ENSEMBL:ENST00000300413 [DatabaseIdentifier:11787165] GeneCards:SNRPD1 [DatabaseIdentifier:11802607] GlyGen:P62314 [DatabaseIdentifier:11840240] HPA:ENSG00000167088-SNRPD1 [DatabaseIdentifier:12124775] OpenTargets:ENSG00000167088 [DatabaseIdentifier:12140516] PDB:8C6J [DatabaseIdentifier:12145808] PDB:8I0P
databaseName	UniProt
dbId	71898
description	recommendedName: Small nuclear ribonucleoprotein Sm D1 shortName: Sm-D1 alternativeName: Sm-D autoantigen alternativeName: snRNP core protein D1
displayName	UniProt:P62314 SNRPD1
geneName	SNRPD1
identifier	P62314
isSequenceChanged	false
keyword	3D-structure Cytoplasm Direct protein sequencing Isopeptide bond Methylation mRNA processing mRNA splicing Nucleus Proteomics identification Reference proteome Repeat Ribonucleoprotein Spliceosome Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SNRPD1
otherIdentifier	11724202_s_at 11724203_at 11724204_s_at 16851344 202690_PM_s_at 202690_s_at 202691_PM_at 202691_at 2409583 2409584 3781089 3781090 3781091 3781092 3781094 3781095 3781099 3781100 3781101 3781102 3781103 3781104 3781105 3781106 37949_at 6632 8020411 A_23_P107644 GE57489 GO:0000243 GO:0000245 GO:0000387 GO:0000398 GO:0003723 GO:0005515 GO:0005634 GO:0005654 GO:0005681 GO:0005682 GO:0005684 GO:0005685 GO:0005686 GO:0005687 GO:0005689 GO:0005737 GO:0005829 GO:0006396 GO:0006397 GO:0008380 GO:0016071 GO:0030532 GO:0034709 GO:0034715 GO:0034719 GO:0036261 GO:0046540 GO:0065003 GO:0071005 GO:0071007 GO:0071011 GO:0071013 GO:0097526 GO:1903241 GO:1990446 GO:1990904 HMNXSV003023218 HMNXSV003031774 HMNXSV003052360 ILMN_1768393 J03798_at PH_hs_0004884 TC18000088.hg g12804598_3p_a_at g5902101_3p_at p7928
physicalEntity	[EntityWithAccessionedSequence:R-HSA-192217] 2xMe-SNRPD1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-191890] SNRPD1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-192215] 2xMe-SNRPD1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000167088] ENSEMBL:ENSG00000167088 SNRPD1 [ReferenceDNASequence:12686142] UCSC:P62314 SNRPD1 [ReferenceDNASequence:11336533] BioGPS Gene:6632 SNRPD1 [ReferenceDNASequence:11392602] COSMIC - genes:SNRPD1 SNRPD2 [ReferenceDNASequence:11412744] CTD Gene:6632 SNRPD1 [ReferenceDNASequence:11428430] dbSNP Gene:6632 SNRPD1 [ReferenceDNASequence:11818803] HGNC:11158 SNRPD1 [ReferenceDNASequence:11877628] KEGG:hsa:6632 SNRPD1 [ReferenceDNASequence:11966322] Monarch:6632 SNRPD1 [ReferenceDNASequence:12050415] NCBI Gene:6632 SNRPD1 [ReferenceDNASequence:12110143] OMIM:601063 SNRPD1
referenceTranscript	[ReferenceRNASequence:12548219] RefSeq:NM_001291916.1 SNRPD1 [ReferenceRNASequence:12548218] RefSeq:NM_006938.4 SNRPD1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SMD1_HUMAN B5BTZ1 P13641
sequenceLength	119
species	[Species:48887] Homo sapiens
stId	uniprot:P62314
url	http://purl.uniprot.org/uniprot/P62314

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-192217] 2xMe-SNRPD1 [cytosol] [EntityWithAccessionedSequence:R-HSA-191890] SNRPD1 [cytosol] [EntityWithAccessionedSequence:R-HSA-192215] 2xMe-SNRPD1 [nucleoplasm]
(referenceSequence)	[ModifiedResidue:192220] monomethylated residue at unknown position
(interactor)	[UndirectedInteraction:11196821] UniProt:O75533 <-> UniProt:P62314 (IntAct) [UndirectedInteraction:11214357] UniProt:P14678 <-> UniProt:P62314 (IntAct) [UndirectedInteraction:11221863] UniProt:P09661 <-> UniProt:P62314 (IntAct) [UndirectedInteraction:11227897] UniProt:P62304 <-> UniProt:P62314 (IntAct) [UndirectedInteraction:11236959] UniProt:P62314 <-> UniProt:P54105 (IntAct) [UndirectedInteraction:11236961] UniProt:P62314 <-> UniProt:Q16637 (IntAct) [UndirectedInteraction:11236963] UniProt:P62314 <-> UniProt:O14893 (IntAct) [UndirectedInteraction:11236965] UniProt:P62314 <-> UniProt:P62316 (IntAct) [UndirectedInteraction:11236967] UniProt:P62314 <-> UniProt:P62306 (IntAct) [UndirectedInteraction:11236969] UniProt:P62314 <-> UniProt:P08621 (IntAct) [UndirectedInteraction:11236971] UniProt:P62314 <-> UniProt:O95400 (IntAct) [UndirectedInteraction:11236973] UniProt:P62314 <-> UniProt:P27958-PRO_0000037573 (IntAct) [UndirectedInteraction:11236975] UniProt:P62314 <-> UniProt:Q15428 (IntAct) [UndirectedInteraction:11236977] UniProt:P62314 <-> UniProt:P62310 (IntAct) [UndirectedInteraction:11236979] UniProt:P62314 <-> UniProt:Q8WXD5 (IntAct) [UndirectedInteraction:11236981] UniProt:P62314 <-> UniProt:O43395 (IntAct) [UndirectedInteraction:11236983] UniProt:P62314 <-> UniProt:P08579 (IntAct) [UndirectedInteraction:11236985] UniProt:P62314 <-> UniProt:P63162 (IntAct) [UndirectedInteraction:11236987] UniProt:P62314 <-> UniProt:Q8TEQ6 (IntAct) [UndirectedInteraction:11236989] UniProt:P62314 <-> UniProt:P35637 (IntAct) [UndirectedInteraction:11236991] UniProt:P62314 <-> UniProt:P09234 (IntAct) [UndirectedInteraction:11236993] UniProt:P62314 <-> UniProt:P62312 (IntAct) [UndirectedInteraction:11236995] UniProt:P62314 <-> UniProt:Q8WWY3 (IntAct) [UndirectedInteraction:11236997] UniProt:P62314 <-> UniProt:P14678-2 (IntAct)

UniProt:P62314 SNRPD1 Show undefined attributes

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