UniProt:P62312 LSM6

chain
  • chain:1-80
checksum 21167891FDE804F1
comment
  • FUNCTION Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable).SUBUNIT Component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:10523320, PubMed:26912367, PubMed:28781166). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (PubMed:26912367). LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome (PubMed:10523320, PubMed:26912367, PubMed:28781166). Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7 (PubMed:12515382).INTERACTION Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
crossReference
databaseName UniProt
dbId 72279
description
  • recommendedName: U6 snRNA-associated Sm-like protein LSm6
displayName UniProt:P62312 LSM6
geneName
  • LSM6
identifier P62312
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cytoplasm
  • Direct protein sequencing
  • mRNA processing
  • mRNA splicing
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Ribonucleoprotein
  • RNA-binding
  • rRNA processing
  • Spliceosome
  • tRNA processing
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • LSM6
otherIdentifier
  • 11157
  • 11721137_a_at
  • 11721138_x_at
  • 16971226
  • 205036_PM_at
  • 205036_at
  • 2746292
  • 2746293
  • 2746294
  • 2746295
  • 2746296
  • 2746297
  • 2746298
  • 2746299
  • 2746300
  • 2746303
  • 2746304
  • 2746307
  • 2746308
  • 2746309
  • 2746310
  • 2746311
  • 2746312
  • 2746313
  • 2746314
  • 2746315
  • 2746316
  • 2746317
  • 2746318
  • 2746319
  • 2746320
  • 2746321
  • 2746322
  • 2746324
  • 2746326
  • 2746328
  • 35991_at
  • 3810955
  • 8097679
  • A_14_P109721
  • A_14_P115263
  • A_23_P259451
  • GE55262
  • GO:0000398
  • GO:0000932
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005681
  • GO:0005688
  • GO:0005730
  • GO:0005732
  • GO:0005737
  • GO:0005829
  • GO:0006364
  • GO:0006397
  • GO:0006399
  • GO:0006402
  • GO:0008033
  • GO:0008380
  • GO:0016071
  • GO:0030490
  • GO:0030532
  • GO:0043226
  • GO:0046540
  • GO:0046982
  • GO:0071005
  • GO:0120115
  • GO:1990904
  • HMNXSV003040144
  • ILMN_1675462
  • PH_hs_0022666
  • PH_hs_0038133
  • TC04000717.hg
  • TC04002247.hg
  • g5901997_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • LSM6_HUMAN
  • Q4W5J5
  • Q9Y4Y8
sequenceLength 80
species [Species:48887] Homo sapiens
stId uniprot:P62312
url http://purl.uniprot.org/uniprot/P62312
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