UniProt:P62253 UBE2G1

chain
  • chain:1-170
  • initiator methionine:1
  • chain:2-170
checksum 36B61766D995B332
comment
  • FUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PATHWAY Protein modification; protein ubiquitination.INTERACTION Widely expressed, mainly in skeletal muscle.PTM Autoubiquitinated in vitro.SIMILARITY Belongs to the ubiquitin-conjugating enzyme family.
crossReference
databaseName UniProt
dbId 66753
description
  • recommendedName: Ubiquitin-conjugating enzyme E2 G1 ecNumber evidence="5"2.3.2.23 alternativeName: E2 ubiquitin-conjugating enzyme G1 alternativeName: E217K alternativeName: UBC7 alternativeName: Ubiquitin carrier protein G1 alternativeName: Ubiquitin-protein ligase G1 component recommendedName: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed /component
displayName UniProt:P62253 UBE2G1
geneName
  • UBE2G1
  • UBE2G
identifier P62253
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • ATP-binding
  • Direct protein sequencing
  • Nucleotide-binding
  • Proteomics identification
  • Reference proteome
  • Transferase
  • Ubl conjugation
  • Ubl conjugation pathway
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • UBE2G1
otherIdentifier
  • 11722027_s_at
  • 11722028_at
  • 1423_at
  • 16840006
  • 209141_PM_at
  • 209141_at
  • 209142_PM_s_at
  • 209142_s_at
  • 226005_PM_at
  • 226005_at
  • 3742062
  • 3742064
  • 3742066
  • 3742068
  • 3742069
  • 3742070
  • 3742071
  • 3742072
  • 3742073
  • 3742076
  • 3742077
  • 3742078
  • 3742079
  • 3742083
  • 3742089
  • 3742090
  • 3742092
  • 3742095
  • 3742096
  • 3742102
  • 3742103
  • 3742104
  • 37662_at
  • 49474_at
  • 7326
  • 8011626
  • A_23_P27066
  • A_24_P296520
  • D78514_at
  • GE56908
  • GE57301
  • GE637268
  • GO:0000166
  • GO:0000209
  • GO:0003824
  • GO:0004842
  • GO:0005515
  • GO:0005524
  • GO:0005829
  • GO:0006511
  • GO:0016567
  • GO:0016740
  • GO:0019787
  • GO:0030163
  • GO:0031625
  • GO:0032446
  • GO:0043161
  • GO:0061631
  • GO:0070062
  • GO:0070534
  • GO:0070936
  • GO:0140096
  • HMNXSV003002792
  • HMNXSV003055294
  • Hs.296273.0.A1_3p_at
  • Hs.78563.0.A3_3p_at
  • ILMN_1719039
  • ILMN_1814465
  • ILMN_1886353
  • PH_hs_0004530
  • PH_hs_0005846
  • TC17001020.hg
  • g12803862_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • UB2G1_HUMAN
  • B2R7P2
  • D3DTK0
  • Q99462
sequenceLength 170
species [Species:48887] Homo sapiens
stId uniprot:P62253
url http://purl.uniprot.org/uniprot/P62253
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