Reactome | UniProt:P62244 RPS15A

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UniProt:P62244 RPS15A Show undefined attributes

chain	initiator methionine:1 chain:2-130
checksum	D4AC1E8864E3A184
comment	FUNCTION Component of the small ribosomal subunit (PubMed:23636399). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Required for proper erythropoiesis (PubMed:27909223).SUBUNIT Component of the 40S ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).INTERACTION The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the universal ribosomal protein uS8 family.
crossReference	[DatabaseIdentifier:12148680] PDB:9B0R [DatabaseIdentifier:12364202] RefSeq:NP_001025180.1 [DatabaseIdentifier:12364203] RefSeq:NP_001010.2 [DatabaseIdentifier:12284646] Pharos - Targets:P62244 [DatabaseIdentifier:12263320] PRO:P62244 [DatabaseIdentifier:12148785] PDB:8YOO [DatabaseIdentifier:12148782] PDB:8YOP [DatabaseIdentifier:12148751] PDB:6ZMW [DatabaseIdentifier:12148739] PDB:7QP6 [DatabaseIdentifier:12148735] PDB:9BLN [DatabaseIdentifier:12148763] PDB:8T4S [DatabaseIdentifier:12148752] PDB:7WTV [DatabaseIdentifier:12148762] PDB:6G18 [DatabaseIdentifier:12148746] PDB:5VYC [DatabaseIdentifier:12148743] PDB:9ED0 [DatabaseIdentifier:12148775] PDB:8GLP [DatabaseIdentifier:12148757] PDB:8XSY [DatabaseIdentifier:12148738] PDB:8OZ0 [DatabaseIdentifier:12148765] PDB:6Z6L [DatabaseIdentifier:12148761] PDB:8XSX [DatabaseIdentifier:12148771] PDB:7TQL [DatabaseIdentifier:12148756] PDB:7WTZ [DatabaseIdentifier:12148774] PDB:6ZXD [DatabaseIdentifier:12148768] PDB:8QOI [DatabaseIdentifier:12148760] PDB:7WTX [DatabaseIdentifier:12148793] PDB:9B0F [DatabaseIdentifier:12148787] PDB:9G8O [DatabaseIdentifier:12148788] PDB:6IP6 [DatabaseIdentifier:12140101] PDB:7MQA [DatabaseIdentifier:12148741] PDB:9AZS [DatabaseIdentifier:12148776] PDB:6ZXG [DatabaseIdentifier:12148789] PDB:6IP5 [DatabaseIdentifier:12148759] PDB:8XSZ [DatabaseIdentifier:12148748] PDB:6ZN5 [DatabaseIdentifier:12148773] PDB:6ZXE [DatabaseIdentifier:12148779] PDB:6ZXH [DatabaseIdentifier:12148766] PDB:6Z6N [DatabaseIdentifier:12148747] PDB:6ZMT [DatabaseIdentifier:12148791] PDB:5FLX [DatabaseIdentifier:12148769] PDB:7K5I [DatabaseIdentifier:12148755] PDB:7WTU [DatabaseIdentifier:12148749] PDB:8IFD [DatabaseIdentifier:12148784] PDB:6ZON [DatabaseIdentifier:12148736] PDB:6ZLW [DatabaseIdentifier:12148783] PDB:9G8M [DatabaseIdentifier:12148737] PDB:6ZM7 [DatabaseIdentifier:12148772] PDB:7R4X [DatabaseIdentifier:12146422] PDB:6ZMO [DatabaseIdentifier:12148742] PDB:6ZVJ [DatabaseIdentifier:12148767] PDB:6ZOJ [DatabaseIdentifier:12148758] PDB:6ZV6 [DatabaseIdentifier:12148754] PDB:7WTT [DatabaseIdentifier:12148744] PDB:8IFE [DatabaseIdentifier:12156080] PDB:6FEC [DatabaseIdentifier:12148740] PDB:7QP7 [DatabaseIdentifier:12148778] PDB:6ZXF [DatabaseIdentifier:12148745] PDB:7XNX [DatabaseIdentifier:12148777] PDB:5AJ0 [DatabaseIdentifier:12148770] PDB:8K2C [DatabaseIdentifier:12148753] PDB:7WTW [DatabaseIdentifier:12148786] PDB:6Y57 [DatabaseIdentifier:12148764] PDB:6Z6M [DatabaseIdentifier:12146421] PDB:6ZMI [DatabaseIdentifier:12148792] PDB:8UIK [DatabaseIdentifier:12156081] PDB:6ZOK [DatabaseIdentifier:12146423] PDB:6ZVH [DatabaseIdentifier:12148780] PDB:6ZP4 [DatabaseIdentifier:12148790] PDB:6IP8 [DatabaseIdentifier:12148750] PDB:7XNY [DatabaseIdentifier:12148727] PDB:8PJ6 [DatabaseIdentifier:12148675] PDB:6OLI [DatabaseIdentifier:12148720] PDB:8PJ4 [DatabaseIdentifier:12148665] PDB:8G5Y [DatabaseIdentifier:12148716] PDB:6QZP [DatabaseIdentifier:12148714] PDB:5LKS [DatabaseIdentifier:12148663] PDB:9C3H [DatabaseIdentifier:12148703] PDB:8UKB [DatabaseIdentifier:12148704] PDB:4UG0 [DatabaseIdentifier:12148698] PDB:9B0N [DatabaseIdentifier:12148694] PDB:9B0J [DatabaseIdentifier:12148728] PDB:7WU0 [DatabaseIdentifier:12148702] PDB:6G4W [DatabaseIdentifier:12148701] PDB:6G4S [DatabaseIdentifier:12148661] PDB:8UJK [DatabaseIdentifier:12148725] PDB:6G5I [DatabaseIdentifier:12148733] PDB:6XA1 [DatabaseIdentifier:12148730] PDB:6ZME [DatabaseIdentifier:12148707] PDB:8ZDD [DatabaseIdentifier:12148718] PDB:9AZC [DatabaseIdentifier:12148658] PDB:8JDM [DatabaseIdentifier:12148668] PDB:9B0W [DatabaseIdentifier:12148667] PDB:6OLF [DatabaseIdentifier:12148689] PDB:8UJ9 [DatabaseIdentifier:12148664] PDB:8UJJ [DatabaseIdentifier:12148671] PDB:6OLG [DatabaseIdentifier:12148662] PDB:6OM0 [DatabaseIdentifier:12148679] PDB:9B0Q [DatabaseIdentifier:12148678] PDB:8G61 [DatabaseIdentifier:12148672] PDB:8G5Z [DatabaseIdentifier:12148732] PDB:7A09 [DatabaseIdentifier:12148700] PDB:8PJ1 [DatabaseIdentifier:12148731] PDB:6ZUO [DatabaseIdentifier:12148708] PDB:8G6J [DatabaseIdentifier:12148692] PDB:8XP2 [DatabaseIdentifier:12148687] PDB:9B11 [DatabaseIdentifier:12148691] PDB:8UIY [DatabaseIdentifier:12148682] PDB:8Y0W [DatabaseIdentifier:12148721] PDB:9BKD [DatabaseIdentifier:12148719] PDB:5OA3 [DatabaseIdentifier:12148699] PDB:6Y0G [DatabaseIdentifier:12148685] PDB:8Y0X [DatabaseIdentifier:12154015] PDB:6YBW [DatabaseIdentifier:12140947] PDB:7MQ8 [DatabaseIdentifier:12148724] PDB:8PJ3 [DatabaseIdentifier:12148711] PDB:8ZDC [DatabaseIdentifier:12148710] PDB:8ZDB [DatabaseIdentifier:12148709] PDB:6OM7 [DatabaseIdentifier:12148684] PDB:8G60 [DatabaseIdentifier:12148677] PDB:8XXM [DatabaseIdentifier:12148681] PDB:5A2Q [DatabaseIdentifier:12148657] PDB:8JDL [DatabaseIdentifier:12148683] PDB:9B0O [DatabaseIdentifier:12148690] PDB:9B0S [DatabaseIdentifier:12148660] PDB:8JDK [DatabaseIdentifier:12140946] PDB:7MQ9 [DatabaseIdentifier:12148715] PDB:9AZN [DatabaseIdentifier:12148705] PDB:6G51 [DatabaseIdentifier:12148693] PDB:8XP3 [DatabaseIdentifier:12148666] PDB:8PPK [DatabaseIdentifier:12148722] PDB:8PJ5 [DatabaseIdentifier:12148697] PDB:4V6X [DatabaseIdentifier:12148706] PDB:6G53 [DatabaseIdentifier:12148729] PDB:6Y2L [DatabaseIdentifier:12148723] PDB:8PJ2 [DatabaseIdentifier:12148695] PDB:9B0G [DatabaseIdentifier:12148659] PDB:8JDJ [DatabaseIdentifier:12148688] PDB:8UIZ [DatabaseIdentifier:12148669] PDB:6OLE [DatabaseIdentifier:12148674] PDB:8XXL [DatabaseIdentifier:12148686] PDB:9B0P [DatabaseIdentifier:12148673] PDB:8PPL [DatabaseIdentifier:12148717] PDB:5T2C [DatabaseIdentifier:12148712] PDB:6OLZ [DatabaseIdentifier:12148670] PDB:8XXN [DatabaseIdentifier:12148696] PDB:9B0H [DatabaseIdentifier:12153090] PDB:7WTS [DatabaseIdentifier:11470650] ENSEMBL:ENSG00000134419 [DatabaseIdentifier:11567590] ENSEMBL:ENSP00000318646 [DatabaseIdentifier:11567591] ENSEMBL:ENSP00000457000 [DatabaseIdentifier:11567592] ENSEMBL:ENSP00000458528 [DatabaseIdentifier:11567593] ENSEMBL:ENSP00000458115 [DatabaseIdentifier:11690289] ENSEMBL:ENST00000563390 [DatabaseIdentifier:11690290] ENSEMBL:ENST00000572008 [DatabaseIdentifier:11690291] ENSEMBL:ENST00000322989 [DatabaseIdentifier:11690292] ENSEMBL:ENST00000565420 [DatabaseIdentifier:11786727] GeneCards:RPS15A [DatabaseIdentifier:11802194] GlyGen:P62244 [DatabaseIdentifier:11839806] HPA:ENSG00000134419-RPS15A [DatabaseIdentifier:12124334] OpenTargets:ENSG00000134419 [DatabaseIdentifier:12135617] Orphanet:RPS15A [DatabaseIdentifier:12148676] PDB:8UJB [DatabaseIdentifier:12148726] PDB:6G5H
databaseName	UniProt
dbId	72344
description	recommendedName: fullName evidence="6"Small ribosomal subunit protein uS8 alternativeName: 40S ribosomal protein S15a
displayName	UniProt:P62244 RPS15A
geneName	RPS15A OK/SW-cl.82
identifier	P62244
isSequenceChanged	false
keyword	3D-structure Cytoplasm Diamond-Blackfan anemia Direct protein sequencing Nucleus Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPS15A
otherIdentifier	11723251_at 11753656_x_at 11753694_x_at 11757363_x_at 11758880_at 11758881_x_at 16824463 200781_PM_s_at 200781_s_at 229882_PM_at 229882_at 235309_PM_at 235309_at 2409816 2410356 2456846 2456847 2904730 3129993 34316_at 34317_g_at 3650334 3650336 3650337 3683019 3683020 3683021 3683022 3683023 3683024 3683025 3683026 3683027 3683028 3683029 3683030 3683031 3683032 3683033 3683034 3683035 3683036 3900471 3900476 44303_at 49788_at 6210 7999827 A_24_P221366 A_33_P3304282 GE78955 GE87302 GO:0002181 GO:0003723 GO:0003735 GO:0005198 GO:0005515 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0005840 GO:0006412 GO:0008284 GO:0009615 GO:0016020 GO:0022626 GO:0022627 GO:0032040 GO:0042274 GO:0045787 GO:0070062 GO:1990904 HMNXSV003050685 Hs.2953.1.S1_3p_at Hs.9879.0.S1_3p_at ILMN_1787949 ILMN_2255310 ILMN_2337241 PH_hs_0028251 PH_hs_0038573 TC16000914.hg X62691_at g4506688_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-72345] RPS15A [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6791191] RPS15A [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000134419] ENSEMBL:ENSG00000134419 RPS15A [ReferenceDNASequence:12685473] UCSC:P62244 RPS15A [ReferenceDNASequence:11335625] BioGPS Gene:6210 RPS15A [ReferenceDNASequence:11392528] COSMIC - genes:RPS15A RPS15A [ReferenceDNASequence:11412005] CTD Gene:6210 RPS15A [ReferenceDNASequence:11428333] dbSNP Gene:6210 RPS15A [ReferenceDNASequence:11818366] HGNC:10389 RPS15A [ReferenceDNASequence:11876809] KEGG:hsa:6210 RPS15A [ReferenceDNASequence:11965414] Monarch:6210 RPS15A [ReferenceDNASequence:12049507] NCBI Gene:6210 RPS15A [ReferenceDNASequence:12109746] OMIM:603674 RPS15A
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RS15A_HUMAN P39027 P39031 Q3MHD9 Q8C023 Q9BV24
sequenceLength	130
species	[Species:48887] Homo sapiens
stId	uniprot:P62244
url	http://purl.uniprot.org/uniprot/P62244

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