Reactome | UniProt:P62195 PSMC5

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UniProt:P62195 PSMC5 Show undefined attributes

chain	initiator methionine:1 chain:2-406
checksum	29C6410C4A85A7F7
comment	FUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.SUBUNIT Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components (PubMed:27342858, PubMed:27428775). Component of a complex with USP49 and RUVBL1 (PubMed:23824326). Interacts with PRPF19. Interacts with TRIM5 (PubMed:22078707). Interacts with NDC80 (PubMed:10409732, PubMed:9295362). Interacts with PAAF1 (PubMed:15831487). Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR) (By similarity). Interacts with ERCC6 (PubMed:26030138).INTERACTION Belongs to the AAA ATPase family.
crossReference	[DatabaseIdentifier:11471198] ENSEMBL:ENSG00000087191 [DatabaseIdentifier:12365573] RefSeq:NP_002796.4 [DatabaseIdentifier:12365575] RefSeq:XP_054172684.1 [DatabaseIdentifier:12365574] RefSeq:NP_001186092.1 [DatabaseIdentifier:12284926] Pharos - Targets:P62195 [DatabaseIdentifier:12263811] PRO:P62195 [DatabaseIdentifier:12145917] PDB:7W3K [DatabaseIdentifier:12145937] PDB:7W3B [DatabaseIdentifier:12145933] PDB:6MSD [DatabaseIdentifier:12145930] PDB:7W3H [DatabaseIdentifier:12145926] PDB:5VGZ [DatabaseIdentifier:12145935] PDB:7W3A [DatabaseIdentifier:12145939] PDB:6MSJ [DatabaseIdentifier:12145940] PDB:6WJN [DatabaseIdentifier:12145924] PDB:7W3C [DatabaseIdentifier:12145942] PDB:7W37 [DatabaseIdentifier:12145932] PDB:8K0G [DatabaseIdentifier:12145929] PDB:7W3G [DatabaseIdentifier:12145919] PDB:7QXW [DatabaseIdentifier:12145921] PDB:7QXP [DatabaseIdentifier:12145910] PDB:9E8O [DatabaseIdentifier:12145912] PDB:9E8Q [DatabaseIdentifier:12145914] PDB:7QXX [DatabaseIdentifier:12145923] PDB:7QXN [DatabaseIdentifier:12145925] PDB:7W3I [DatabaseIdentifier:12145918] PDB:5GJR [DatabaseIdentifier:12145913] PDB:5GJQ [DatabaseIdentifier:12145916] PDB:7QY7 [DatabaseIdentifier:12145941] PDB:7W39 [DatabaseIdentifier:12145936] PDB:6MSH [DatabaseIdentifier:12145944] PDB:7W38 [DatabaseIdentifier:12145922] PDB:7W3F [DatabaseIdentifier:12145927] PDB:7QXU [DatabaseIdentifier:12145943] PDB:6MSB [DatabaseIdentifier:12145920] PDB:5VHF [DatabaseIdentifier:12145934] PDB:6MSG [DatabaseIdentifier:12145938] PDB:6MSK [DatabaseIdentifier:12145911] PDB:9E8L [DatabaseIdentifier:12145928] PDB:7W3J [DatabaseIdentifier:12145915] PDB:7W3M [DatabaseIdentifier:12145901] PDB:8JRT [DatabaseIdentifier:12145869] PDB:5LN3 [DatabaseIdentifier:12145883] PDB:7QYB [DatabaseIdentifier:12145891] PDB:9E8K [DatabaseIdentifier:12145887] PDB:5VHN [DatabaseIdentifier:12145890] PDB:9E8J [DatabaseIdentifier:12145874] PDB:5VHP [DatabaseIdentifier:12145875] PDB:5VHO [DatabaseIdentifier:12173637] PDB:2KRK [DatabaseIdentifier:12145870] PDB:5T0C [DatabaseIdentifier:12145878] PDB:5VHQ [DatabaseIdentifier:12145884] PDB:5VHJ [DatabaseIdentifier:12145899] PDB:9NKG [DatabaseIdentifier:12173636] PDB:3KW6 [DatabaseIdentifier:12145907] PDB:5VFT [DatabaseIdentifier:12145881] PDB:5VHH [DatabaseIdentifier:12145900] PDB:9NKF [DatabaseIdentifier:12145880] PDB:5VHS [DatabaseIdentifier:12145873] PDB:5T0G [DatabaseIdentifier:12145893] PDB:9E8I [DatabaseIdentifier:12145908] PDB:5VFS [DatabaseIdentifier:12145896] PDB:6WJD [DatabaseIdentifier:12145892] PDB:9E8H [DatabaseIdentifier:12145885] PDB:5VHI [DatabaseIdentifier:12145879] PDB:8CVT [DatabaseIdentifier:12145877] PDB:5L4G [DatabaseIdentifier:12145872] PDB:5T0H [DatabaseIdentifier:12145871] PDB:5M32 [DatabaseIdentifier:12145888] PDB:5VHM [DatabaseIdentifier:12145909] PDB:9E8N [DatabaseIdentifier:12145889] PDB:9E8G [DatabaseIdentifier:12145886] PDB:8JTI [DatabaseIdentifier:12145897] PDB:9NKI [DatabaseIdentifier:12145905] PDB:5VFR [DatabaseIdentifier:12145895] PDB:8USC [DatabaseIdentifier:12145902] PDB:9NKJ [DatabaseIdentifier:12145882] PDB:7QYA [DatabaseIdentifier:12145904] PDB:8JRI [DatabaseIdentifier:12145903] PDB:5VFP [DatabaseIdentifier:12145906] PDB:5VFQ [DatabaseIdentifier:12145876] PDB:5VHR [DatabaseIdentifier:12145894] PDB:8USB [DatabaseIdentifier:12145868] PDB:5T0I [DatabaseIdentifier:12145867] PDB:5T0J [DatabaseIdentifier:12145898] PDB:5VFU [DatabaseIdentifier:12124613] OpenTargets:ENSG00000087191 [DatabaseIdentifier:11840083] HPA:ENSG00000087191-PSMC5 [DatabaseIdentifier:11802460] GlyGen:P62195 [DatabaseIdentifier:11787004] GeneCards:PSMC5 [DatabaseIdentifier:11691069] ENSEMBL:ENST00000310144 [DatabaseIdentifier:11691066] ENSEMBL:ENST00000581882 [DatabaseIdentifier:11691068] ENSEMBL:ENST00000375812 [DatabaseIdentifier:11691067] ENSEMBL:ENST00000580864 [DatabaseIdentifier:11568367] ENSEMBL:ENSP00000364970 [DatabaseIdentifier:11568368] ENSEMBL:ENSP00000463938 [DatabaseIdentifier:11568369] ENSEMBL:ENSP00000462495 [DatabaseIdentifier:11568370] ENSEMBL:ENSP00000310572
databaseName	UniProt
dbId	62228
description	recommendedName: 26S proteasome regulatory subunit 8 alternativeName: 26S proteasome AAA-ATPase subunit RPT6 alternativeName: Proteasome 26S subunit ATPase 5 alternativeName: Proteasome subunit p45 alternativeName: Thyroid hormone receptor-interacting protein 1 shortName: TRIP1 alternativeName: p45/SUG
displayName	UniProt:P62195 PSMC5
geneName	PSMC5 SUG1
identifier	P62195
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Nucleotide-binding Nucleus Phosphoprotein Proteasome Proteomics identification Reference proteome
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	PSMC5
otherIdentifier	11756554_x_at 16837029 209503_PM_s_at 209503_s_at 3730942 3730943 3730944 3730945 3730946 3730947 3730948 3730949 3730950 3730951 3730952 3730953 3730954 3730955 3730956 3730957 3730958 3730959 3730960 3730961 3730962 3730963 3730964 3730965 3730966 3730967 3730968 3730969 3730970 3730971 3730972 3730973 37766_s_at 5705 8009227 A_14_P106486 A_14_P125043 A_23_P164035 GE54277 GO:0000166 GO:0000502 GO:0005102 GO:0005515 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005838 GO:0006355 GO:0006357 GO:0008134 GO:0008540 GO:0016020 GO:0016234 GO:0016787 GO:0016887 GO:0017025 GO:0022624 GO:0030163 GO:0031410 GO:0031531 GO:0031595 GO:0031597 GO:0036402 GO:0043069 GO:0043161 GO:0045892 GO:0045893 GO:0070062 GO:0072562 GO:0090261 GO:0140296 GO:0140297 GO:1901800 HMNXSV003036198 ILMN_1780189 L38810_at PH_hs_0004597 TC17000772.hg g2661070_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-68780] PSMC5 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-174312] PSMC5 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000087191] ENSEMBL:ENSG00000087191 PSMC5 [ReferenceDNASequence:12685914] UCSC:P62195 PSMC5 [ReferenceDNASequence:12110003] OMIM:601681 PSMC5 [ReferenceDNASequence:12050119] NCBI Gene:5705 PSMC5 [ReferenceDNASequence:11966026] Monarch:5705 PSMC5 [ReferenceDNASequence:11877354] KEGG:hsa:5705 PSMC5 [ReferenceDNASequence:11818645] HGNC:9552 PSMC5 [ReferenceDNASequence:11428399] dbSNP Gene:5705 PSMC5 [ReferenceDNASequence:11412492] CTD Gene:5705 PSMC5 [ReferenceDNASequence:11392579] COSMIC - genes:PSMC5 PSMC5 [ReferenceDNASequence:11336237] BioGPS Gene:5705 PSMC5
referenceTranscript	[ReferenceRNASequence:12547409] RefSeq:NM_002805.5 PSMC5 [ReferenceRNASequence:12547408] RefSeq:NM_001199163.2 PSMC5 [ReferenceRNASequence:12547410] RefSeq:XM_054316709.1 PSMC5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PRS8_HUMAN A8K3Z3 A8K763 O35051 O43208 P47210 P52915 P52916
sequenceLength	406
species	[Species:48887] Homo sapiens
stId	uniprot:P62195
url	http://purl.uniprot.org/uniprot/P62195

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