Reactome | UniProt:P62191 PSMC1

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UniProt:P62191 PSMC1 Show undefined attributes

chain	initiator methionine:1 chain:2-440
checksum	ACA80782F4F96F49
comment	FUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.SUBUNIT Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC1 and few additional components (PubMed:27342858, PubMed:27428775). Interacts with SCA7 (PubMed:11734547). Interacts with NGLY1 (PubMed:15358861). Interacts with PAAF1 (PubMed:15831487).INTERACTION The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the AAA ATPase family.
created	[InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
crossReference	[DatabaseIdentifier:11471366] ENSEMBL:ENSG00000100764 [DatabaseIdentifier:12365999] RefSeq:NP_002793.2 [DatabaseIdentifier:12365997] RefSeq:XP_054232396.1 [DatabaseIdentifier:12365998] RefSeq:NP_001317141.1 [DatabaseIdentifier:12284987] Pharos - Targets:P62191 [DatabaseIdentifier:12263937] PRO:P62191 [DatabaseIdentifier:12145926] PDB:5VGZ [DatabaseIdentifier:12145934] PDB:6MSG [DatabaseIdentifier:12145909] PDB:9E8N [DatabaseIdentifier:12145921] PDB:7QXP [DatabaseIdentifier:12145917] PDB:7W3K [DatabaseIdentifier:12145939] PDB:6MSJ [DatabaseIdentifier:12145925] PDB:7W3I [DatabaseIdentifier:12145912] PDB:9E8Q [DatabaseIdentifier:12145908] PDB:5VFS [DatabaseIdentifier:12145943] PDB:6MSB [DatabaseIdentifier:12145915] PDB:7W3M [DatabaseIdentifier:12145937] PDB:7W3B [DatabaseIdentifier:12145932] PDB:8K0G [DatabaseIdentifier:12145944] PDB:7W38 [DatabaseIdentifier:12145911] PDB:9E8L [DatabaseIdentifier:12145940] PDB:6WJN [DatabaseIdentifier:12145910] PDB:9E8O [DatabaseIdentifier:12145916] PDB:7QY7 [DatabaseIdentifier:12145913] PDB:5GJQ [DatabaseIdentifier:12145930] PDB:7W3H [DatabaseIdentifier:12145920] PDB:5VHF [DatabaseIdentifier:12145914] PDB:7QXX [DatabaseIdentifier:12145935] PDB:7W3A [DatabaseIdentifier:12145928] PDB:7W3J [DatabaseIdentifier:12145918] PDB:5GJR [DatabaseIdentifier:12145924] PDB:7W3C [DatabaseIdentifier:12145941] PDB:7W39 [DatabaseIdentifier:12145922] PDB:7W3F [DatabaseIdentifier:12145938] PDB:6MSK [DatabaseIdentifier:12145919] PDB:7QXW [DatabaseIdentifier:12145933] PDB:6MSD [DatabaseIdentifier:12145923] PDB:7QXN [DatabaseIdentifier:12145929] PDB:7W3G [DatabaseIdentifier:12145927] PDB:7QXU [DatabaseIdentifier:12145942] PDB:7W37 [DatabaseIdentifier:12145936] PDB:6MSH [DatabaseIdentifier:12145896] PDB:6WJD [DatabaseIdentifier:12145900] PDB:9NKF [DatabaseIdentifier:12145871] PDB:5M32 [DatabaseIdentifier:12145884] PDB:5VHJ [DatabaseIdentifier:12145890] PDB:9E8J [DatabaseIdentifier:12145907] PDB:5VFT [DatabaseIdentifier:12145898] PDB:5VFU [DatabaseIdentifier:12145897] PDB:9NKI [DatabaseIdentifier:12145887] PDB:5VHN [DatabaseIdentifier:12147535] PDB:8USD [DatabaseIdentifier:12145878] PDB:5VHQ [DatabaseIdentifier:12145873] PDB:5T0G [DatabaseIdentifier:12145906] PDB:5VFQ [DatabaseIdentifier:12145880] PDB:5VHS [DatabaseIdentifier:12145875] PDB:5VHO [DatabaseIdentifier:12145905] PDB:5VFR [DatabaseIdentifier:12145889] PDB:9E8G [DatabaseIdentifier:12145903] PDB:5VFP [DatabaseIdentifier:12145886] PDB:8JTI [DatabaseIdentifier:12145867] PDB:5T0J [DatabaseIdentifier:12145899] PDB:9NKG [DatabaseIdentifier:12145893] PDB:9E8I [DatabaseIdentifier:12145874] PDB:5VHP [DatabaseIdentifier:12145892] PDB:9E8H [DatabaseIdentifier:12145877] PDB:5L4G [DatabaseIdentifier:12145901] PDB:8JRT [DatabaseIdentifier:12145876] PDB:5VHR [DatabaseIdentifier:12145902] PDB:9NKJ [DatabaseIdentifier:12145888] PDB:5VHM [DatabaseIdentifier:12145904] PDB:8JRI [DatabaseIdentifier:12145879] PDB:8CVT [DatabaseIdentifier:12145869] PDB:5LN3 [DatabaseIdentifier:12145872] PDB:5T0H [DatabaseIdentifier:12145868] PDB:5T0I [DatabaseIdentifier:12145881] PDB:5VHH [DatabaseIdentifier:12145894] PDB:8USB [DatabaseIdentifier:12145882] PDB:7QYA [DatabaseIdentifier:12145885] PDB:5VHI [DatabaseIdentifier:12145895] PDB:8USC [DatabaseIdentifier:12145891] PDB:9E8K [DatabaseIdentifier:12145870] PDB:5T0C [DatabaseIdentifier:12145883] PDB:7QYB [DatabaseIdentifier:12124677] OpenTargets:ENSG00000100764 [DatabaseIdentifier:11840144] HPA:ENSG00000100764-PSMC1 [DatabaseIdentifier:11802521] GlyGen:P62191 [DatabaseIdentifier:11787068] GeneCards:PSMC1 [DatabaseIdentifier:11691313] ENSEMBL:ENST00000543772 [DatabaseIdentifier:11691312] ENSEMBL:ENST00000261303 [DatabaseIdentifier:11568613] ENSEMBL:ENSP00000261303 [DatabaseIdentifier:11568614] ENSEMBL:ENSP00000445147
databaseName	UniProt
dbId	98941
description	recommendedName: 26S proteasome regulatory subunit 4 shortName: P26s4 alternativeName: 26S proteasome AAA-ATPase subunit RPT2 alternativeName: Proteasome 26S subunit ATPase 1
displayName	UniProt:P62191 PSMC1
geneName	PSMC1
identifier	P62191
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Deafness Direct protein sequencing Intellectual disability Isopeptide bond Lipoprotein Membrane Myristate Nucleotide-binding Nucleus Phosphoprotein Proteasome Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	PSMC1
otherIdentifier	11716545_x_at 11748303_x_at 16787409 204219_3p_s_at 204219_PM_s_at 204219_s_at 2471205 2471210 2628584 2628585 2628586 2628587 2628588 2628589 2628590 2628591 2628592 2628593 2703461 2822886 2822887 2822888 2869838 3026199 3406993 3406995 3406997 3407003 3407007 3548281 3548286 3548287 3548288 3548290 3548291 3548292 3548293 3548295 3548298 3548299 3548300 3548301 3548302 3548303 3548307 3548308 3548310 3548312 3548314 3548316 3548317 3548318 3548320 3548322 3548324 5700 688_at 7976189 8080923 A_14_P118170 A_24_P347488 A_32_P57870 A_32_P9700 GE61348 GO:0000166 GO:0000502 GO:0003723 GO:0005515 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005838 GO:0008540 GO:0016020 GO:0016787 GO:0016887 GO:0022624 GO:0030163 GO:0036402 GO:0043161 GO:1901800 HMNXSV003052549 ILMN_1710406 ILMN_1721659 ILMN_1736353 L02426_at PH_hs_0032853 TC14000552.hg g4506206_3p_a_at g4506206_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-68768] PSMC1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-174338] PSMC1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000100764] ENSEMBL:ENSG00000100764 PSMC1 [ReferenceDNASequence:12686061] UCSC:P62191 PSMC1 [ReferenceDNASequence:12110054] OMIM:602706 PSMC1 [ReferenceDNASequence:12050304] NCBI Gene:5700 PSMC1 [ReferenceDNASequence:11966211] Monarch:5700 PSMC1 [ReferenceDNASequence:11877531] KEGG:hsa:5700 PSMC1 [ReferenceDNASequence:11818706] HGNC:9547 PSMC1 [ReferenceDNASequence:11428424] dbSNP Gene:5700 PSMC1 [ReferenceDNASequence:11412615] CTD Gene:5700 PSMC1 [ReferenceDNASequence:11392598] COSMIC - genes:PSMC1 PSMC1 [ReferenceDNASequence:11336422] BioGPS Gene:5700 PSMC1
referenceTranscript	[ReferenceRNASequence:12547836] RefSeq:NM_001330212.2 PSMC1 [ReferenceRNASequence:12547835] RefSeq:XM_054376421.1 PSMC1 [ReferenceRNASequence:12547834] RefSeq:NM_002802.2 PSMC1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PRS4_HUMAN B4DR63 P49014 Q03527 Q6IAW0 Q6NW36 Q96AZ3
sequenceLength	440
species	[Species:48887] Homo sapiens
stId	uniprot:P62191
url	http://purl.uniprot.org/uniprot/P62191

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