UniProt:P62082 Rps7

chain
  • chain:1-194
checksum E21089929CC061E9
comment
  • FUNCTION Component of the small ribosomal subunit (PubMed:36517592). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). Required for rRNA maturation (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).SUBUNIT Component of the small ribosomal subunit (PubMed:36517592). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (By similarity). Binds IPO9 with high affinity (By similarity). Interacts with NEK6 (By similarity). Interacts with DESI2 (By similarity). Interacts with IPO5, IPO7 and KPNB1; these interactions may be involved in RPS7 nuclear import for the assembly of ribosomal subunits (By similarity).SUBCELLULAR LOCATION Although RPS7 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPS7 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. Colocalizes with NEK6 in the centrosome.PTM Phosphorylated by NEK6.PTM Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization.SIMILARITY Belongs to the eukaryotic ribosomal protein eS7 family.
crossReference
databaseName UniProt
dbId 63746
description
  • recommendedName: fullName evidence="3"Small ribosomal subunit protein eS7 alternativeName: 40S ribosomal protein S7
displayName UniProt:P62082 Rps7
geneName
  • Rps7
identifier P62082
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cytoplasm
  • Cytoskeleton
  • Isopeptide bond
  • Nucleus
  • Reference proteome
  • Ribonucleoprotein
  • Ribosomal protein
  • Ubl conjugation
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Rps7
otherIdentifier
  • 101212_at
  • 10399760
  • 10461389
  • 10607391
  • 1419364_a_at
  • 1435593_x_at
  • 1455364_a_at
  • 17280392
  • 20115
  • 4339846
  • 4394578
  • 4407035
  • 4420621
  • 4424637
  • 4522641
  • 4531641
  • 4533132
  • 4539791
  • 4617406
  • 4618029
  • 4650118
  • 4726720
  • 4791471
  • 5072541
  • 5247650
  • 5328111
  • 5344655
  • 5354758
  • 5378837
  • 5428604
  • 5463275
  • 5544427
  • 5594568
  • A_51_P127545
  • GE36029
  • GO:0001843
  • GO:0002181
  • GO:0003730
  • GO:0003735
  • GO:0005198
  • GO:0005634
  • GO:0005730
  • GO:0005737
  • GO:0005783
  • GO:0005813
  • GO:0005815
  • GO:0005829
  • GO:0005840
  • GO:0005856
  • GO:0006364
  • GO:0006412
  • GO:0010628
  • GO:0014033
  • GO:0019901
  • GO:0022626
  • GO:0022627
  • GO:0030154
  • GO:0032040
  • GO:0032991
  • GO:0042274
  • GO:0045202
  • GO:0048027
  • GO:0050821
  • GO:0098772
  • GO:0098794
  • GO:1902255
  • GO:1990904
  • GO:1990948
  • GO:2000059
  • ILMN_2710068
  • ILMN_2916116
  • mMC024767
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RS7_MOUSE
  • P23821
  • P24818
sequenceLength 194
species [Species:48892] Mus musculus
stId uniprot:P62082
url http://purl.uniprot.org/uniprot/P62082
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