UniProt:P61981 YWHAG

chain
  • chain:1-247
  • initiator methionine:1
  • chain:2-247
checksum B0D16C6DE1F4455D
comment
  • FUNCTION Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15696159, PubMed:16511572, PubMed:36732624). Binding generally results in the modulation of the activity of the binding partner (PubMed:16511572). Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 (PubMed:36732624). Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1 (PubMed:29121962). Reduces keratinocyte intercellular adhesion, via interacting with PKP1 and sequestering it in the cytoplasm, thereby reducing its incorporation into desmosomes (PubMed:29678907). Plays a role in mitochondrial protein catabolic process (also named MALM) that promotes the degradation of damaged proteins inside mitochondria (PubMed:22532927).SUBUNIT Homodimer (PubMed:17085597). Part of a complex that contains DSG3, PKP1, YAP1 and YWHAG; the complex is required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes (PubMed:31835537). Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2 (PubMed:10433554, PubMed:15159416, PubMed:15454081). Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm (PubMed:15696159). Interacts with GAB2 (PubMed:19172738). Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53 (PubMed:16511572). Interacts with PKA-phosphorylated AANAT and SIRT2 (PubMed:11427721, PubMed:18249187). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (PubMed:28202711). Interacts with MARK2 and MARK3 (PubMed:16959763). Interacts with MEFV (PubMed:27030597). Interacts with ENDOG, TSC2 and PIK3C3; interaction with ENDOG weakens its interaction with TSC2 and PIK3C3 (PubMed:33473107). Interacts with (phosphorylated) WDR24 (PubMed:36732624). Interacts with BEST1; this interaction promotes L-glutamate channel activity leading to the positive regulation of NMDA glutamate receptor activity through the L-glutamate secretion (PubMed:29121962). Interacts with PKP1 (when phosphorylated); the interaction results in translocation of PKP1 to the cytoplasm and loss of intercellular adhesion in keratinocytes (PubMed:29678907). Interacts with SPATA18/MIEAP (isoforms 1 and 2); a protein that also plays a role in MALM (PubMed:22532927).INTERACTION Translocates to the mitochondrial matrix following induction of MALM (mitochondrial protein catabolic process).TISSUE SPECIFICITY Highly expressed in brain, skeletal muscle, and heart.PTM Phosphorylated by various PKC isozymes.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the 14-3-3 family.
crossReference
databaseName UniProt
dbId 48907
description
  • recommendedName: fullName evidence="30"14-3-3 protein gamma alternativeName: Protein kinase C inhibitor protein 1 shortName: KCIP-1 component recommendedName: 14-3-3 protein gamma, N-terminally processed /component
displayName UniProt:P61981 YWHAG
geneName
  • YWHAG
identifier P61981
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • Epilepsy
  • Mitochondrion
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • YWHAG
otherIdentifier
  • 11744340_s_at
  • 11746826_a_at
  • 11749397_a_at
  • 17058905
  • 222985_PM_at
  • 222985_at
  • 3057651
  • 3057652
  • 3057661
  • 3057662
  • 3057663
  • 44862_at
  • 63282_f_at
  • 65826_at
  • 67256_at
  • 7532
  • 8140398
  • A_23_P123022
  • A_24_P106681
  • GE53664
  • GO:0002181
  • GO:0002841
  • GO:0002842
  • GO:0003723
  • GO:0005080
  • GO:0005159
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005739
  • GO:0005759
  • GO:0005829
  • GO:0005925
  • GO:0006469
  • GO:0006605
  • GO:0007165
  • GO:0008104
  • GO:0008426
  • GO:0009966
  • GO:0016020
  • GO:0019904
  • GO:0022409
  • GO:0030163
  • GO:0030971
  • GO:0031146
  • GO:0031669
  • GO:0031982
  • GO:0032869
  • GO:0032880
  • GO:0034198
  • GO:0038202
  • GO:0042149
  • GO:0042802
  • GO:0043161
  • GO:0043226
  • GO:0045202
  • GO:0045664
  • GO:0045947
  • GO:0045948
  • GO:0048167
  • GO:0050821
  • GO:0050868
  • GO:0050870
  • GO:0061462
  • GO:0070062
  • GO:0085020
  • GO:0098772
  • GO:0098793
  • GO:0140031
  • GO:0140311
  • GO:1904262
  • GO:1904263
  • HMNXSV003004536
  • ILMN_1750145
  • ILMN_2228809
  • PH_hs_0002201
  • TC07001540.hg
  • g6016837_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • 1433G_HUMAN
  • O70457
  • P35214
  • Q6FH52
  • Q9UDP2
  • Q9UN99
sequenceLength 247
species [Species:48887] Homo sapiens
stId uniprot:P61981
url http://purl.uniprot.org/uniprot/P61981

Referrals

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