UniProt:P61019 RAB2A

chain
  • initiator methionine:1
  • chain:2-212
checksum F8731E3F8FB399A3
comment
  • FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:37821429). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (PubMed:37821429). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (PubMed:26209634). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28483915).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors (GDIs) which inhibit the dissociation of the nucleotide from the GTPase.SUBUNIT Interacts with PRKCI (PubMed:14570876). Interacts with TRIP11 (PubMed:25473115). Interacts (in GTP-bound form) with GARIN1B (By similarity). Interacts (GTP-bound) with HOPS complex component VPS39; interaction contributes to obtaining a functional HOPS complex that promotes autophagosome-lysosome membrane fusion driven by STX17-SNAP29-VAMP8 (PubMed:37821429). In contrast with mouse ortholog, not able to interact with VPS41 (PubMed:37821429).INTERACTION Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).ALTERNATIVE PRODUCTS Switch I, switch II and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.PTM Prenylated. Prenylation is required for association with cellular membranes.SIMILARITY Belongs to the small GTPase superfamily. Rab family.
crossReference
databaseName UniProt
dbId 62768
description
  • recommendedName: fullName evidence="12"Ras-related protein Rab-2A ecNumber evidence="1"3.6.5.2
displayName UniProt:P61019 RAB2A
geneName
  • RAB2A
  • RAB2
identifier P61019
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cytoplasmic vesicle
  • Endoplasmic reticulum
  • ER-Golgi transport
  • Golgi apparatus
  • GTP-binding
  • Hydrolase
  • Lipoprotein
  • Magnesium
  • Membrane
  • Metal-binding
  • Nucleotide-binding
  • Prenylation
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Transport
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • RAB2A
otherIdentifier
  • 11750002_a_at
  • 11758857_at
  • 11758858_s_at
  • 11758859_at
  • 17069250
  • 208730_PM_x_at
  • 208730_x_at
  • 208731_PM_at
  • 208731_at
  • 208732_PM_at
  • 208732_at
  • 208733_PM_at
  • 208733_at
  • 208734_PM_x_at
  • 208734_x_at
  • 3100172
  • 3100173
  • 3100174
  • 3100189
  • 3100190
  • 3100198
  • 3100199
  • 3100200
  • 3100203
  • 3100204
  • 3100205
  • 3100206
  • 3100208
  • 3100209
  • 3100210
  • 3100211
  • 3100222
  • 3100223
  • 3100224
  • 3100228
  • 3100229
  • 3100230
  • 3100231
  • 3100232
  • 3100233
  • 3100234
  • 3100235
  • 32581_at
  • 5862
  • 623_s_at
  • 8146564
  • A_14_P117424
  • A_14_P201746
  • A_23_P253949
  • A_23_P340251
  • A_24_P102080
  • GE543964
  • GE56685
  • GE86646
  • GO:0000139
  • GO:0000166
  • GO:0000421
  • GO:0001669
  • GO:0003924
  • GO:0003925
  • GO:0005515
  • GO:0005525
  • GO:0005634
  • GO:0005737
  • GO:0005765
  • GO:0005783
  • GO:0005789
  • GO:0005794
  • GO:0005829
  • GO:0006888
  • GO:0007030
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0016236
  • GO:0016787
  • GO:0019003
  • GO:0031410
  • GO:0033116
  • GO:0042470
  • GO:0046872
  • GO:0061909
  • GO:0070062
  • GO:0098772
  • HMNXSV003016033
  • Hs.78305.0.A1_3p_at
  • Hs.78305.0.A3_3p_at
  • Hs.78305.0.A4_3p_at
  • Hs.78305.0.A5_3p_at
  • ILMN_1652394
  • ILMN_1891857
  • M28213_s_at
  • PH_hs_0004517
  • PH_hs_0038533
  • TC08000410.hg
  • X12953_at
  • g550061_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RAB2A_HUMAN
  • B2R5W8
  • B4DMQ5
  • P08886
sequenceLength 212
species [Species:48887] Homo sapiens
stId uniprot:P61019
url http://purl.uniprot.org/uniprot/P61019
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