UniProt:P61010 SRP54

chain
  • chain:1-504
checksum 7D7630A43BC5EC2C
comment
  • FUNCTION Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:6413076, PubMed:6938958). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (PubMed:6413076). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)SUBUNIT Component of a signal recognition particle complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6413076, PubMed:6938958). Interacts with RNPS1 (By similarity). Interacts with the SRP receptor subunit SRPRA (By similarity).SUBCELLULAR LOCATION The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA (By similarity). The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another (By similarity). SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (By similarity).DOMAIN The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.SIMILARITY Belongs to the GTP-binding SRP family. SRP54 subfamily.
created [InstanceEdit:445185] May, B, 2009-10-29
crossReference
databaseName UniProt
dbId 445212
description
  • recommendedName: Signal recognition particle subunit SRP54 ecNumber evidence="2"3.6.5.4 alternativeName: Signal recognition particle 54 kDa protein
displayName UniProt:P61010 SRP54
geneName
  • SRP54
identifier P61010
isSequenceChanged false
keyword
  • 3D-structure
  • Cytoplasm
  • Direct protein sequencing
  • Endoplasmic reticulum
  • GTP-binding
  • Hydrolase
  • Nucleotide-binding
  • Nucleus
  • Reference proteome
  • Ribonucleoprotein
  • RNA-binding
  • Signal recognition particle
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • SRP54
otherIdentifier
  • 403953
  • Cfa.3810.1.S1_at
  • CfaAffx.20628.1.S1_s_at
  • GO:0000166
  • GO:0003723
  • GO:0003924
  • GO:0005525
  • GO:0005634
  • GO:0005737
  • GO:0005783
  • GO:0005786
  • GO:0005829
  • GO:0006614
  • GO:0008312
  • GO:0016607
  • GO:0016787
  • GO:0016887
  • GO:0019003
  • GO:0030154
  • GO:0030851
  • GO:0030942
  • GO:0043021
  • GO:0045047
  • GO:0048500
  • GO:1990904
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SRP54_CANLF
  • P13624
sequenceLength 504
species [Species:49646] Canis familiaris
stId uniprot:P61010
url http://purl.uniprot.org/uniprot/P61010
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