UniProt:P60904 Dnajc5

chain
  • chain:1-198
checksum 52F98261FBAD978F
comment
  • FUNCTION Acts as a co-chaperone for the SNARE protein SNAP-25 (PubMed:22187053). Involved in the calcium-mediated control of a late stage of exocytosis (PubMed:20847230). Acts as a general chaperone in regulated exocytosis (By similarity). May have an important role in presynaptic function (By similarity). May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).SUBUNIT Homodimer (Probable). Interacts with the chaperone complex consisting of HSC70 and SGTA (PubMed:17034881, PubMed:20847230). Interacts with ZDHHC13 (via ANK repeats) (PubMed:25253725, PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:25253725, PubMed:26198635). Interacts with SYT1, SYT5 and SYT7, and with SYT9, forming a complex with SNAP25 (PubMed:20847230). The interaction with SYT9 is stimulated tenfold in presence of calcium (PubMed:20847230).SUBCELLULAR LOCATION The association with membranes is regulated by palmitoylation (By similarity). Colocalizes with insulin granules, when overexpressed in an islet cell line (PubMed:17034881).PTM Formation of the chaperone complex DNAJC5/HSC70 is not regulated by phosphorylation (PubMed:20847230). Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58 (By similarity). This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions (By similarity).PTM Palmitoylated (PubMed:17034881). Could be palmitoylated by DHHC3, DHHC7, DHHC15 and DHHC17 (By similarity). Palmitoylation occurs probably in the cysteine-rich domain and regulates DNAJC5 membrane attachment (PubMed:17034881).DISRUPTION PHENOTYPE Defective SNAP-25 function, which causes neurodegeneration by impairing SNARE-complex assembly (PubMed:22187053).
created [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09
crossReference
databaseName UniProt
dbId 89140
description
  • recommendedName: fullName evidence="10"DnaJ homolog subfamily C member 5 alternativeName: fullName evidence="2"Cysteine string protein shortName evidence="2"CSP alternativeName: fullName evidence="9"Cysteine-string protein isoform alpha
displayName UniProt:P60904 Dnajc5
geneName
  • Dnajc5
  • Cspalpha
identifier P60904
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cell membrane
  • Chaperone
  • Cytoplasm
  • Cytoplasmic vesicle
  • Direct protein sequencing
  • Lipoprotein
  • Membrane
  • Palmitate
  • Phosphoprotein
  • Reference proteome
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Dnajc5
otherIdentifier
  • 10479639
  • 109760_at
  • 109761_g_at
  • 114406_at
  • 114508_at
  • 13002
  • 137715_at
  • 1436179_a_at
  • 1436180_at
  • 1448850_a_at
  • 1448851_a_at
  • 1460498_a_at
  • 17381058
  • 4305601
  • 4311519
  • 4320213
  • 4335820
  • 4472250
  • 4493959
  • 4551950
  • 4580050
  • 4629083
  • 4663874
  • 4688322
  • 4705725
  • 4820679
  • 4872622
  • 4978335
  • 5089952
  • 5237189
  • 5353160
  • 5415291
  • 5452877
  • 5453980
  • 5474204
  • 5486104
  • 5559564
  • 93211_at
  • A_51_P178585
  • A_52_P113126
  • A_52_P113129
  • A_55_P1982732
  • A_55_P1982733
  • A_55_P1982737
  • A_55_P2093720
  • GE112744
  • GE119902
  • GE1448722
  • GO:0005515
  • GO:0005737
  • GO:0005829
  • GO:0005886
  • GO:0006457
  • GO:0008021
  • GO:0016020
  • GO:0030658
  • GO:0030672
  • GO:0031410
  • GO:0031594
  • GO:0042470
  • GO:0042584
  • GO:0043008
  • GO:0043524
  • GO:0051402
  • GO:0060203
  • GO:0098693
  • GO:0098793
  • ILMN_2469641
  • ILMN_2501026
  • ILMN_2671708
  • Msa.21307.0_s_at
  • mMC015836
  • mMR031233
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DNJC5_MOUSE
  • P54101
sequenceLength 198
species [Species:48892] Mus musculus
stId uniprot:P60904
url http://purl.uniprot.org/uniprot/P60904
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