UniProt:P59632 3a

chain
  • chain:1-274
checksum E48C7D44A4DE34FE
comment
  • FUNCTION Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Down-regulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination.SUBUNIT Homotetramer composed of two homodimers linked non covalently. Interacts with M, S and E proteins. Also interacts with the accessory protein 7a.INTERACTION The cell surface expressed protein can undergo endocytosis. The protein is secreted in association with membranous structures.DOMAIN The second or the third transmembrane region are responsible for Golgi localization.PTM Exists in both O-glycosylated and non-glycosylated forms. The glycosylated form is associated with the virion.
created [InstanceEdit:9678191] Orlic-Milacic, Marija, 2020-03-13
crossReference
databaseName UniProt
dbId 9678189
description
  • recommendedName: ORF3a protein alternativeName: Accessory protein 3a alternativeName: Protein 3a alternativeName: Protein U274 alternativeName: Protein X1
displayName UniProt:P59632 3a
geneName
  • 3a
identifier P59632
isSequenceChanged false
keyword
  • 3D-structure
  • Apoptosis
  • Glycoprotein
  • Host cell membrane
  • Host cytoplasm
  • Host Golgi apparatus
  • Host membrane
  • Host-virus interaction
  • Inhibition of host innate immune response by virus
  • Inhibition of host interferon receptors by virus
  • Inhibition of host interferon signaling pathway by virus
  • Interferon antiviral system evasion
  • Ion channel
  • Ion transport
  • Membrane
  • Reference proteome
  • Secreted
  • Transmembrane
  • Transmembrane helix
  • Transport
  • Viral immunoevasion
  • Viral ion channel
  • Virion
modified [InstanceEdit:9909836] Weiser, Joel, 2024-05-14
moleculeType Protein
name
  • 3a
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AP3A_SARS
  • Q7T6R6
  • Q7TA10
  • Q7TA18
  • Q7TFB0
  • Q7TLD0
  • Q80BV5
sequenceLength 274
species [Species:9678119] Human SARS coronavirus
stId uniprot:P59632
url http://purl.uniprot.org/uniprot/P59632

Referrals

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