UniProt:P57729 RAB38

chain
  • chain:1-211
checksum 0D16B42A1B237539
comment
  • FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB38 may be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) including the BLOC-3 complex composed of HPS1 and HPS4 which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) including SGSM2 which increase the GTP hydrolysis activity (By similarity). Inhibited by GDP dissociation inhibitors (GDIs) (Probable).SUBUNIT Interacts with ANKRD27 (PubMed:19403694).INTERACTION Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).TISSUE SPECIFICITY Expressed in melanocytes.DOMAIN Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.PTM Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated.SIMILARITY Belongs to the small GTPase superfamily. Rab family.
crossReference
databaseName UniProt
dbId 62788
description
  • recommendedName: Ras-related protein Rab-38 ecNumber evidence="1"3.6.5.2 alternativeName: Melanoma antigen NY-MEL-1
displayName UniProt:P57729 RAB38
geneName
  • RAB38
identifier P57729
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • Cytoplasmic vesicle
  • GTP-binding
  • Hydrolase
  • Lipoprotein
  • Magnesium
  • Membrane
  • Metal-binding
  • Nucleotide-binding
  • Palmitate
  • Prenylation
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Transport
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • RAB38
otherIdentifier
  • 11724146_at
  • 11724147_at
  • 11757999_s_at
  • 16743104
  • 219412_PM_at
  • 219412_at
  • 23682
  • 3385753
  • 3385754
  • 3385755
  • 3385757
  • 3385760
  • 3385761
  • 3385762
  • 3385763
  • 56894_at
  • 7950899
  • A_23_P161563
  • GE62028
  • GO:0000166
  • GO:0003924
  • GO:0005515
  • GO:0005525
  • GO:0005739
  • GO:0005764
  • GO:0005768
  • GO:0005769
  • GO:0005794
  • GO:0005802
  • GO:0005829
  • GO:0005886
  • GO:0006886
  • GO:0007005
  • GO:0007264
  • GO:0012505
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0016787
  • GO:0030670
  • GO:0030742
  • GO:0031090
  • GO:0031410
  • GO:0031982
  • GO:0032438
  • GO:0033162
  • GO:0035646
  • GO:0035650
  • GO:0035651
  • GO:0036461
  • GO:0042470
  • GO:0043226
  • GO:0044233
  • GO:0044297
  • GO:0045335
  • GO:0046872
  • GO:0048023
  • GO:0048471
  • GO:0060155
  • GO:0072657
  • GO:0090383
  • GO:1903232
  • GO:1904377
  • GO:2001247
  • HMNXSV003056950
  • ILMN_2134974
  • PH_hs_0006020
  • TC11002174.hg
  • g11641236_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RAB38_HUMAN
  • Q53XK7
sequenceLength 211
species [Species:48887] Homo sapiens
stId uniprot:P57729
url http://purl.uniprot.org/uniprot/P57729
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