UniProt:P56748 CLDN8

chain
  • chain:1-225
checksum F7920E8E71682473
comment
  • FUNCTION Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity). May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). Cannot form tight junction strands on its own (PubMed:36008380).CATALYTIC ACTIVITY chloride(in) = chloride(out)CATALYTIC ACTIVITY bromide(in) = bromide(out)CATALYTIC ACTIVITY iodide(out) = iodide(in)CATALYTIC ACTIVITY fluoride(in) = fluoride(out)SUBUNIT Can form heteropolymeric strands with other claudins (PubMed:36008380). Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with CLDN4; forms coassem. Interacts with KLHL3.INTERACTION Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells.TISSUE SPECIFICITY Expressed in the epididymis, mainly in the caput segment.PTM Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation.SIMILARITY Belongs to the claudin family.
crossReference
databaseName UniProt
dbId 52246
description
  • recommendedName: Claudin-8
displayName UniProt:P56748 CLDN8
geneName
  • CLDN8
  • UNQ779/PRO1573
identifier P56748
isSequenceChanged false
keyword
  • Cell junction
  • Cell membrane
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Tight junction
  • Transmembrane
  • Transmembrane helix
  • Ubl conjugation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • CLDN8
otherIdentifier
  • 11729831_a_at
  • 11729832_s_at
  • 16924792
  • 214598_PM_at
  • 214598_at
  • 33610_at
  • 33611_g_at
  • 3928416
  • 3928417
  • 3928418
  • 3928419
  • 3928420
  • 3928421
  • 3928422
  • 3928423
  • 3928424
  • 3928425
  • 3928426
  • 3928427
  • 8069795
  • 9073
  • A_23_P427014
  • GE56220
  • GE63157
  • GO:0005198
  • GO:0005515
  • GO:0005783
  • GO:0005886
  • GO:0005923
  • GO:0007155
  • GO:0016020
  • GO:0016323
  • GO:0016327
  • GO:0016338
  • GO:0034330
  • GO:0042802
  • GO:0070161
  • GO:0070830
  • HMNXSV003046247
  • Hs.162209.0.S2_3p_at
  • ILMN_1746676
  • ILMN_2072568
  • PH_hs_0009847
  • TC21000363.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CLD8_HUMAN
  • D3DSE3
  • Q53EX7
sequenceLength 225
species [Species:48887] Homo sapiens
stId uniprot:P56748
url http://purl.uniprot.org/uniprot/P56748
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