Reactome | UniProt:P55957 BID

chain	chain:1-195 chain:61-195 chain:76-195 chain:100-195
checksum	B17A07334C1AFBEF
comment	FUNCTION Induces caspases and apoptosis (PubMed:14583606). Counters the protective effect of BCL2 (By similarity).FUNCTION Induces caspase activation and apoptosis (PubMed:15661737, PubMed:32029622). Translocates to mitochondria following cleavage and disrupts the outer mitochondrial membrane leading to the release of cytochrome c (PubMed:10480954, PubMed:32029622, PubMed:9727491).FUNCTION Induces ICE-like proteases and apoptosis.FUNCTION Induces ICE-like proteases and apoptosis.FUNCTION Does not induce apoptosis.FUNCTION Induces ICE-like proteases and apoptosis.SUBUNIT Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein BCL2 (By similarity). Interacts with PLEKHN1 (PubMed:29531808).SUBUNIT Interacts with humanin; forms fibers with humanin which results in BID conformational changes and sequestering of BID into the fibers, preventing BID activation.SUBUNIT Interacts with ITCH (PubMed:20392206). Interacts with humanin; the interaction prevents BID-induced apoptosis (PubMed:15661737). Interacts with MTCH2 (By similarity).INTERACTION When uncleaved, it is predominantly cytoplasmic.SUBCELLULAR LOCATION Translocates to mitochondria following cleavage.SUBCELLULAR LOCATION Associated with the mitochondrial membrane.SUBCELLULAR LOCATION A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.ALTERNATIVE PRODUCTS Expressed in spleen, pancreas and placenta (at protein level).TISSUE SPECIFICITY Expressed in lung, pancreas and spleen (at protein level).TISSUE SPECIFICITY Expressed in lung and pancreas (at protein level).DOMAIN Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.PTM TNF induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products (PubMed:10480954, PubMed:32029622, PubMed:9727491). Cleaved by CASP6 or CASP8 into a major p15 and minor p13 products, leading to release of cytochrome c (PubMed:32029622). Also cleaved by GZMK to generate p15 (PubMed:10480954).PTM Ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.
crossReference	[DatabaseIdentifier:11486089] ENSEMBL:ENSG00000015475 [DatabaseIdentifier:12399016] RefSeq:NP_932071.1 [DatabaseIdentifier:12399011] RefSeq:NP_001231499.1 [DatabaseIdentifier:12399013] RefSeq:NP_001231498.1 [DatabaseIdentifier:12399017] RefSeq:NP_001187.1 [DatabaseIdentifier:12399015] RefSeq:NP_932070.1 [DatabaseIdentifier:12399012] RefSeq:NP_001231501.1 [DatabaseIdentifier:12399014] RefSeq:NP_001231496.1 [DatabaseIdentifier:12280700] Pharos - Targets:P55957 [DatabaseIdentifier:12237809] PRO:P55957 [DatabaseIdentifier:12147804] PDB:1ZY3 [DatabaseIdentifier:12147803] PDB:4ZEQ [DatabaseIdentifier:12147801] PDB:4BD2 [DatabaseIdentifier:12147808] PDB:5C3F [DatabaseIdentifier:12147815] PDB:4ZII [DatabaseIdentifier:12147813] PDB:2BID [DatabaseIdentifier:12147812] PDB:8SM5 [DatabaseIdentifier:12147800] PDB:7P33 [DatabaseIdentifier:12147806] PDB:5AJJ [DatabaseIdentifier:12147811] PDB:7M5B [DatabaseIdentifier:12147816] PDB:2M5B [DatabaseIdentifier:12147809] PDB:7M5A [DatabaseIdentifier:12147814] PDB:4ZIG [DatabaseIdentifier:12147807] PDB:2M5I [DatabaseIdentifier:12147810] PDB:2KBW [DatabaseIdentifier:12147802] PDB:7QTW [DatabaseIdentifier:12147805] PDB:4QVE [DatabaseIdentifier:12120365] OpenTargets:ENSG00000015475 [DatabaseIdentifier:11589838] ENSEMBL:ENSP00000480414 [DatabaseIdentifier:11589841] ENSEMBL:ENSP00000449236 [DatabaseIdentifier:11589835] ENSEMBL:ENSP00000318822 [DatabaseIdentifier:11589840] ENSEMBL:ENSP00000382669 [DatabaseIdentifier:11589839] ENSEMBL:ENSP00000382667 [DatabaseIdentifier:11589836] ENSEMBL:ENSP00000344594 [DatabaseIdentifier:11589837] ENSEMBL:ENSP00000477773 [DatabaseIdentifier:11712535] ENSEMBL:ENST00000317361 [DatabaseIdentifier:11712536] ENSEMBL:ENST00000551952 [DatabaseIdentifier:11712540] ENSEMBL:ENST00000399767 [DatabaseIdentifier:11712539] ENSEMBL:ENST00000399765 [DatabaseIdentifier:11712537] ENSEMBL:ENST00000614949 [DatabaseIdentifier:11712534] ENSEMBL:ENST00000342111 [DatabaseIdentifier:11712538] ENSEMBL:ENST00000622694 [DatabaseIdentifier:11782787] GeneCards:BID [DatabaseIdentifier:11798443] GlyGen:P55957 [DatabaseIdentifier:11835900] HPA:ENSG00000015475-BID
databaseName	UniProt
dbId	50826
description	recommendedName: BH3-interacting domain death agonist alternativeName: p22 BID shortName: BID component recommendedName: BH3-interacting domain death agonist p15 shortName: p15 BID alternativeName: fullName evidence="15"Cytochrome c Releasing Factor shortName evidence="15"CCRF alternativeName: fullName evidence="12"Truncated Bid shortName evidence="12"tBid /component component recommendedName: BH3-interacting domain death agonist p13 alternativeName: p13 BID /component component recommendedName: BH3-interacting domain death agonist p11 alternativeName: p11 BID /component
displayName	UniProt:P55957 BID
geneName	BID
identifier	P55957
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Apoptosis Cytoplasm Membrane Mitochondrion Mitochondrion outer membrane Phosphoprotein Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	BID
otherIdentifier	11724046_a_at 11732217_a_at 11732218_x_at 11745421_a_at 16932008 204493_PM_at 204493_at 211725_PM_s_at 211725_s_at 227143_PM_s_at 227143_s_at 32725_at 32726_g_at 3951928 3951929 3951930 3951931 3951932 3951934 3951935 3951936 3951937 3951938 3951939 3951940 3951941 3951942 3951943 3951944 3951945 3951951 3951952 3951953 3951954 3951955 3951958 3951959 59612_at 59614_g_at 637 8074261 A_23_P154929 A_24_P187948 A_33_P3227041 GE54366 GO:0001836 GO:0005123 GO:0005515 GO:0005737 GO:0005739 GO:0005741 GO:0005829 GO:0006091 GO:0006626 GO:0006915 GO:0007005 GO:0008625 GO:0008637 GO:0010918 GO:0016020 GO:0031334 GO:0031625 GO:0031966 GO:0033554 GO:0035556 GO:0042129 GO:0042770 GO:0042775 GO:0042981 GO:0043028 GO:0043065 GO:0050678 GO:0051402 GO:0065003 GO:0090150 GO:0090200 GO:0097191 GO:0097284 GO:0097345 GO:0097435 GO:1902108 GO:1902230 GO:1902531 GO:2000045 GO:2000271 GO:2001233 GO:2001235 GO:2001238 GO:2001244 HMNXSV003050536 Hs.315689.1.A1_3p_at ILMN_1763386 ILMN_2259495 ILMN_2372413 PH_hs_0029676 TC22000476.hg g13543452_3p_s_at g4557360_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-139953] BID(61-195) [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-50825] BID(1-195) [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-141373] MYS-BID(61-195) [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-114266] MYS-BID(61-195) [mitochondrial outer membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12106179] OMIM:601997 BID [ReferenceDNASequence:12745586] UCSC:P55957 BID [ReferenceDNASequence:ensembl:ENSG00000015475] ENSEMBL:ENSG00000015475 BID [ReferenceDNASequence:11351410] BioGPS Gene:637 BID [ReferenceDNASequence:11400741] COSMIC - genes:BID BID [ReferenceDNASequence:11406286] CTD Gene:637 BID [ReferenceDNASequence:11437950] dbSNP Gene:637 BID [ReferenceDNASequence:11814396] HGNC:1050 BID [ReferenceDNASequence:11891176] KEGG:hsa:637 BID [ReferenceDNASequence:11981199] Monarch:637 BID [ReferenceDNASequence:12065292] NCBI Gene:637 BID
referenceTranscript	[ReferenceRNASequence:12580716] RefSeq:NM_197966.3 BID [ReferenceRNASequence:12580718] RefSeq:NM_001244570.1 BID [ReferenceRNASequence:12580720] RefSeq:NM_001196.4 BID [ReferenceRNASequence:12580721] RefSeq:NM_001244569.1 BID [ReferenceRNASequence:12580722] RefSeq:NM_001244567.1 BID [ReferenceRNASequence:12580719] RefSeq:NM_001244572.1 BID [ReferenceRNASequence:12580717] RefSeq:NM_197967.2 BID
schemaClass	ReferenceGeneProduct
secondaryIdentifier	BID_HUMAN Q549M7 Q71T04 Q7Z4M9 Q8IY86
sequenceLength	195
species	[Species:48887] Homo sapiens
stId	uniprot:P55957
url	http://purl.uniprot.org/uniprot/P55957

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-139953] BID(61-195) [cytosol] [EntityWithAccessionedSequence:R-HSA-50825] BID(1-195) [cytosol] [EntityWithAccessionedSequence:R-HSA-141373] MYS-BID(61-195) [cytosol] [EntityWithAccessionedSequence:R-HSA-114266] MYS-BID(61-195) [mitochondrial outer membrane]
(referenceSequence)	[ModifiedResidue:141374] myristoylated residue at unknown position
(interactor)	[UndirectedInteraction:11139717] UniProt:P31946 <-> UniProt:P55957 (IntAct) [UndirectedInteraction:11194901] UniProt:Q07817 <-> UniProt:P55957 (IntAct) [UndirectedInteraction:11199725] UniProt:Q03135 <-> UniProt:P55957 (IntAct) [UndirectedInteraction:11233425] UniProt:P55957 <-> UniProt:P10415 (IntAct) [UndirectedInteraction:11233427] UniProt:P55957 <-> UniProt:Q07817-1 (IntAct) [UndirectedInteraction:11233429] UniProt:P55957 <-> UniProt:Q07812 (IntAct) [UndirectedInteraction:11233431] UniProt:P55957 <-> UniProt:Q92843 (IntAct) [UndirectedInteraction:11233433] UniProt:P55957 <-> UniProt:Q16611 (IntAct) [UndirectedInteraction:11233435] UniProt:P55957 <-> UniProt:Q07820 (IntAct) [UndirectedInteraction:11233437] UniProt:P55957 <-> UniProt:Q07440 (IntAct) [UndirectedInteraction:11233441] UniProt:P55957 <-> UniProt:P17361 (IntAct) [UndirectedInteraction:11233443] UniProt:P55957 <-> UniProt:O43865 (IntAct) [UndirectedInteraction:11233445] UniProt:P55957 <-> UniProt:Q96D03 (IntAct) [UndirectedInteraction:11233447] UniProt:P55957 <-> UniProt:Q04864 (IntAct) [UndirectedInteraction:11233449] UniProt:P55957 <-> UniProt:P97287 (IntAct)

UniProt:P55957 BID Show undefined attributes

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