Reactome | UniProt:P55259 GP2

Schema > ReferenceGeneProduct > Entries

UniProt:P55259 GP2 Show undefined attributes

chain	signal peptide:1-28 chain:29-512 propeptide:513-537
checksum	8A6B6A0FC64F50B8
comment	FUNCTION Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.SUBUNIT Interacts with SYCN (By similarity). Interacts with bacterial adhesin fimH (PubMed:19907495, PubMed:35273390).INTERACTION Secreted, after cleavage, in the pancreatic juice.ALTERNATIVE PRODUCTS Expressed in pancreas (at protein level) (PubMed:10760606, PubMed:8666297). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level) (PubMed:19907495).DOMAIN Each ZP domain consists of an N-terminal (ZP-N) and C-terminal (ZP-C) region connected by a flexible linker; the linker allows the ZP domain to wrap around the ZP-C subdomain of the preceding subunit.PTM N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH.CAUTION It is uncertain whether Met-1 or Met-8 is the initiator.
crossReference	[DatabaseIdentifier:12474279] RefSeq:NP_001007242.2 [DatabaseIdentifier:12474280] RefSeq:NP_001007243.2 [DatabaseIdentifier:12474278] RefSeq:NP_001007241.2 [DatabaseIdentifier:12474277] RefSeq:NP_001493.2 [DatabaseIdentifier:12290500] Pharos - Targets:P55259 [DatabaseIdentifier:12273135] PRO:P55259 [DatabaseIdentifier:12213940] PDB:7P6R [DatabaseIdentifier:12213938] PDB:7P6S [DatabaseIdentifier:12213939] PDB:7P6T [DatabaseIdentifier:12213937] PDB:8XC5 [DatabaseIdentifier:12130294] OpenTargets:ENSG00000169347 [DatabaseIdentifier:11845647] HPA:ENSG00000169347-GP2 [DatabaseIdentifier:11792657] GeneCards:GP2 [DatabaseIdentifier:11764943] ENSEMBL:ENST00000381360 [DatabaseIdentifier:11764941] ENSEMBL:ENST00000381362 [DatabaseIdentifier:11764944] ENSEMBL:ENST00000341642 [DatabaseIdentifier:11764942] ENSEMBL:ENST00000302555 [DatabaseIdentifier:11642244] ENSEMBL:ENSP00000370765 [DatabaseIdentifier:11642245] ENSEMBL:ENSP00000370767 [DatabaseIdentifier:11642243] ENSEMBL:ENSP00000343861 [DatabaseIdentifier:11642242] ENSEMBL:ENSP00000304044 [DatabaseIdentifier:11522296] ENSEMBL:ENSG00000169347
databaseName	UniProt
dbId	55816
description	recommendedName: fullName evidence="20"Pancreatic secretory granule membrane major glycoprotein GP2 alternativeName: fullName evidence="20"Pancreatic zymogen granule membrane protein GP-2 alternativeName: ZAP75
displayName	UniProt:P55259 GP2
geneName	GP2
identifier	P55259
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Cytoplasmic vesicle Disulfide bond EGF-like domain Endosome Glycoprotein GPI-anchor Immunity Innate immunity Lipoprotein Membrane Proteomics identification Receptor Reference proteome Secreted Signal
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	GP2
otherIdentifier	11729112_x_at 16824588 206681_PM_x_at 206681_x_at 208473_PM_s_at 208473_s_at 214324_PM_at 214324_at 214325_PM_at 214325_at 2813 3683506 3683507 3683508 3683509 3683510 3683514 3683516 3683518 3683519 3683520 3683521 3683522 3683523 3683524 3683527 3683528 3683529 3683530 3683531 3683537 3683538 3683539 3683540 3683541 3683543 40003_at 7999920 A_24_P190007 GE79544 GO:0002376 GO:0002412 GO:0003823 GO:0005515 GO:0005576 GO:0005615 GO:0005768 GO:0005886 GO:0009897 GO:0009986 GO:0016020 GO:0016324 GO:0031410 GO:0042589 GO:0045087 GO:0045121 GO:0048870 GO:0070062 GO:0098542 GO:0098552 GO:1990266 HMNXSV003009823 HMNXSV003018676 HMNXSV003036102 Hs.274454.0.S1_3p_at Hs.274454.0.S2_3p_at ILMN_1860863 ILMN_2311873 PH_hs_0003552 TC16000923.hg U36221_at g7706490_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8941111] cleaved GPI-GP2 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8940732] GPI-GP2 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8940416] GP2 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9922809] GP2 [zymogen granule] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12768970] UCSC:P55259 GP2 [ReferenceDNASequence:12114868] OMIM:602977 GP2 [ReferenceDNASequence:12100037] NCBI Gene:2813 GP2 [ReferenceDNASequence:12015944] Monarch:2813 GP2 [ReferenceDNASequence:11922671] KEGG:hsa:2813 GP2 [ReferenceDNASequence:11824340] HGNC:4441 GP2 [ReferenceDNASequence:11441566] dbSNP Gene:2813 GP2 [ReferenceDNASequence:11420889] CTD Gene:2813 GP2 [ReferenceDNASequence:11403919] COSMIC - genes:GP2 GP2 [ReferenceDNASequence:11386155] BioGPS Gene:2813 GP2 [ReferenceDNASequence:ensembl:ENSG00000169347] ENSEMBL:ENSG00000169347 GP2
referenceTranscript	[ReferenceRNASequence:12655746] RefSeq:NM_001502.4 GP2 [ReferenceRNASequence:12655745] RefSeq:NM_001007241.3 GP2 [ReferenceRNASequence:12655744] RefSeq:NM_001007242.3 GP2 [ReferenceRNASequence:12655747] RefSeq:NM_001007240.3 GP2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GP2_HUMAN A6NFM9 A6NJA8 Q13338 Q9UIF1
sequenceLength	537
species	[Species:48887] Homo sapiens
stId	uniprot:P55259
url	http://purl.uniprot.org/uniprot/P55259

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8941111] cleaved GPI-GP2 [extracellular region] [EntityWithAccessionedSequence:R-HSA-8940732] GPI-GP2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8940416] GP2 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-9922809] GP2 [zymogen granule]
(referenceSequence)	[GroupModifiedResidue:8941079] L-asparagine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 512 [GroupModifiedResidue:8940784] L-asparagine amide (GPI-anchor amidated amino acid carboxyl end residue(1?)) at 512