UniProt:P55064 AQP5

chain
  • chain:1-265
checksum 053C10E6A17EAFDA
comment
  • FUNCTION Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:18768791, PubMed:8621489). Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity).CATALYTIC ACTIVITY H2O(in) = H2O(out)SUBUNIT Homotetramer; each monomer provides an independent water pore (PubMed:18768791, PubMed:26569106). Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity.INTERACTION Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane.TISSUE SPECIFICITY Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level).DOMAIN Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the MIP/aquaporin (TC 1.A.8) family.
crossReference
databaseName UniProt
dbId 50184
description
  • recommendedName: fullName evidence="10"Aquaporin-5 shortName: AQP-5
displayName UniProt:P55064 AQP5
geneName
  • AQP5
identifier P55064
isSequenceChanged false
keyword
  • 3D-structure
  • Cell membrane
  • Cytoplasmic vesicle
  • Disease variant
  • Glycoprotein
  • Membrane
  • Palmoplantar keratoderma
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • AQP5
otherIdentifier
  • 11721531_a_at
  • 16750974
  • 213611_3p_at
  • 213611_PM_at
  • 213611_at
  • 32909_at
  • 3414316
  • 3414317
  • 3414319
  • 3414320
  • 3414321
  • 3414323
  • 3414324
  • 3414325
  • 362
  • 7955297
  • 91275_at
  • A_14_P129916
  • A_23_P117104
  • A_23_P366812
  • GE899136
  • GO:0005515
  • GO:0005783
  • GO:0005886
  • GO:0005902
  • GO:0006833
  • GO:0009925
  • GO:0015250
  • GO:0015267
  • GO:0015670
  • GO:0016020
  • GO:0016324
  • GO:0022600
  • GO:0030157
  • GO:0030659
  • GO:0031410
  • GO:0042476
  • GO:0042802
  • GO:0046541
  • GO:0048593
  • GO:0051289
  • GO:0055085
  • GO:0065003
  • GO:0070062
  • GO:0071476
  • Hs.298023.0.S2_3p_at
  • Hs.298023.0.S2_3p_x_at
  • ILMN_1807036
  • PH_hs_0015393
  • TC12000384.hg
  • U46569_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AQP5_HUMAN
  • Q6FGW8
sequenceLength 265
species [Species:48887] Homo sapiens
stId uniprot:P55064
url http://purl.uniprot.org/uniprot/P55064
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