Reactome | UniProt:P55040 GEM

chain	chain:1-296
checksum	B7BB3F2CA96D338F
comment	FUNCTION Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.SUBUNIT Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1.INTERACTION Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.INDUCTION By mitogens.PTM Phosphorylated on tyrosine residues.SIMILARITY Belongs to the small GTPase superfamily. RGK family.
crossReference	[DatabaseIdentifier:11523542] ENSEMBL:ENSG00000164949 [DatabaseIdentifier:12477240] RefSeq:NP_005252.1 [DatabaseIdentifier:12477239] RefSeq:NP_859053.1 [DatabaseIdentifier:12291612] Pharos - Targets:P55040 [DatabaseIdentifier:12274438] PRO:P55040 [DatabaseIdentifier:12219401] PDB:2CJW [DatabaseIdentifier:12219403] PDB:2HT6 [DatabaseIdentifier:12219402] PDB:2G3Y [DatabaseIdentifier:12131421] OpenTargets:ENSG00000164949 [DatabaseIdentifier:11846759] HPA:ENSG00000164949-GEM [DatabaseIdentifier:11830644] HMDB Protein:HMDBP11454 [DatabaseIdentifier:11793771] GeneCards:GEM [DatabaseIdentifier:11766928] ENSEMBL:ENST00000396194 [DatabaseIdentifier:11766927] ENSEMBL:ENST00000297596 [DatabaseIdentifier:11644228] ENSEMBL:ENSP00000297596 [DatabaseIdentifier:11644229] ENSEMBL:ENSP00000379497
databaseName	UniProt
dbId	55572
description	recommendedName: GTP-binding protein GEM alternativeName: GTP-binding mitogen-induced T-cell protein alternativeName: RAS-like protein KIR
displayName	UniProt:P55040 GEM
geneName	GEM KIR
identifier	P55040
isSequenceChanged	false
keyword	3D-structure Calmodulin-binding Cell membrane GTP-binding Membrane Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	GEM
otherIdentifier	11720558_a_at 17079210 204472_PM_at 204472_at 2669 3144935 3144936 3144937 3144938 3144941 3144945 3144946 3144947 3144948 3144949 3144950 3144951 3144952 3144953 3144954 37279_at 8151816 A_23_P257043 GE58914 GO:0000166 GO:0000278 GO:0000287 GO:0002376 GO:0003924 GO:0005246 GO:0005515 GO:0005516 GO:0005525 GO:0005634 GO:0005886 GO:0006955 GO:0007165 GO:0007166 GO:0009898 GO:0016020 GO:0016787 GO:0019003 GO:0030496 GO:0043226 GO:0051233 GO:0051276 GO:0051310 GO:0072686 GO:0098772 GO:1901842 HMNXSV003008060 ILMN_1677092 ILMN_1678968 ILMN_2367883 PH_hs_0004561 TC08001432.hg U10550_at g4885262_3p_at g4885262_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9769962] GEM [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000164949] ENSEMBL:ENSG00000164949 GEM [ReferenceDNASequence:12769690] UCSC:P55040 GEM [ReferenceDNASequence:12115881] OMIM:600164 GEM [ReferenceDNASequence:12101297] NCBI Gene:2669 GEM [ReferenceDNASequence:12017204] Monarch:2669 GEM [ReferenceDNASequence:11923848] KEGG:hsa:2669 GEM [ReferenceDNASequence:11825465] HGNC:4234 GEM [ReferenceDNASequence:11441734] dbSNP Gene:2669 GEM [ReferenceDNASequence:11422368] CTD Gene:2669 GEM [ReferenceDNASequence:11404077] COSMIC - genes:GEM GEM [ReferenceDNASequence:11387415] BioGPS Gene:2669 GEM
referenceTranscript	[ReferenceRNASequence:12658746] RefSeq:NM_005261.4 GEM [ReferenceRNASequence:12658747] RefSeq:NM_181702.3 GEM
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GEM_HUMAN B2RA31
sequenceLength	296
species	[Species:48887] Homo sapiens
stId	uniprot:P55040
url	http://purl.uniprot.org/uniprot/P55040

UniProt:P55040 GEM Show undefined attributes

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