Reactome | UniProt:P55010 EIF5

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UniProt:P55010 EIF5 Show undefined attributes

chain	chain:1-431
checksum	C6CCC3A255F9B9BC
comment	FUNCTION Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:11166181, PubMed:22813744, PubMed:24319994). In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3) (PubMed:11166181). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD) (PubMed:22813744). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC (PubMed:24319994). When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP (PubMed:11166181). Start codon recognition also induces a conformational change of the PIC to a closed state (PubMed:22813744). This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC (PubMed:22813744). Finally, EIF5 stabilizes the PIC in its closed conformation (PubMed:22813744).SUBUNIT Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with eIF1A (EIF1AX) during scanning (PubMed:24319994). Interacts through its C-terminal domain (CTD) with EIF1 or with eIF2-beta (EIF2S2) (mutually exclusive) through a common binding site (PubMed:21745818, PubMed:22813744). Interacts through its C-terminal domain (CTD) with the CTD of EIF5B (PubMed:30211544). Interacts with FMR1 isoform 6; this interaction occurs in a RNA-dependent manner (PubMed:24658146).INTERACTION Belongs to the eIF-2-beta/eIF-5 family.
crossReference	[DatabaseIdentifier:12477496] RefSeq:NP_001960.2 [DatabaseIdentifier:12477495] RefSeq:NP_892116.2 [DatabaseIdentifier:12291747] Pharos - Targets:P55010 [DatabaseIdentifier:12274567] PRO:P55010 [DatabaseIdentifier:12219823] PDB:2E9H [DatabaseIdentifier:12148723] PDB:8PJ2 [DatabaseIdentifier:12148724] PDB:8PJ3 [DatabaseIdentifier:12148738] PDB:8OZ0 [DatabaseIdentifier:12219824] PDB:2G2K [DatabaseIdentifier:12219822] PDB:2IU1 [DatabaseIdentifier:12131554] OpenTargets:ENSG00000100664 [DatabaseIdentifier:11846894] HPA:ENSG00000100664-EIF5 [DatabaseIdentifier:11830769] HMDB Protein:HMDBP08454 [DatabaseIdentifier:11809860] GlyGen:P55010 [DatabaseIdentifier:11793905] GeneCards:EIF5 [DatabaseIdentifier:11767106] ENSEMBL:ENST00000392715 [DatabaseIdentifier:11767107] ENSEMBL:ENST00000558506 [DatabaseIdentifier:11767108] ENSEMBL:ENST00000216554 [DatabaseIdentifier:11644409] ENSEMBL:ENSP00000453743 [DatabaseIdentifier:11644408] ENSEMBL:ENSP00000216554 [DatabaseIdentifier:11644407] ENSEMBL:ENSP00000376477 [DatabaseIdentifier:11523652] ENSEMBL:ENSG00000100664
databaseName	UniProt
dbId	72615
description	recommendedName: Eukaryotic translation initiation factor 5 shortName: eIF-5
displayName	UniProt:P55010 EIF5
geneName	EIF5
identifier	P55010
isSequenceChanged	false
keyword	3D-structure Cytoplasm GTP-binding GTPase activation Initiation factor Isopeptide bond Nucleotide-binding Phosphoprotein Protein biosynthesis Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	EIF5
otherIdentifier	11724724_a_at 11724725_a_at 11724726_s_at 11724727_a_at 11741224_s_at 11758020_s_at 11758275_s_at 11763890_at 16789178 16789207 167_at 1983 208290_PM_s_at 208290_s_at 208705_PM_s_at 208705_s_at 208706_PM_s_at 208706_s_at 208707_PM_at 208707_at 208708_PM_x_at 208708_x_at 241843_PM_at 241843_at 32171_at 3553619 3553620 3553621 3553622 3553623 3553624 3553625 3553626 3553627 3553628 3553629 3553630 3553631 3553632 3553633 3553634 3553635 3553636 3553637 3553638 3553639 3553640 3553641 3553642 3553643 3553644 3553645 3553646 3553647 3553648 3553649 3553650 3553651 3553652 3553653 3553654 3553655 3553687 3882824 3999211 3999212 51379_at 53809_at 7977058 7977075 A_14_P114933 A_23_P205265 A_24_P398810 A_24_P415959 GE84166 GE86973 GE86974 GO:0000166 GO:0001732 GO:0003723 GO:0003743 GO:0005092 GO:0005096 GO:0005515 GO:0005525 GO:0005737 GO:0005829 GO:0005886 GO:0006412 GO:0006413 GO:0006446 GO:0042255 GO:0045202 GO:0045296 GO:0065003 GO:0071074 GO:0098772 HMNXSV003012350 HMNXSV003034967 Hs.186541.0.A1_3p_at Hs.286236.1.S1_3p_a_at Hs.286236.1.S3_3p_s_at Hs.286236.1.S4_3p_at ILMN_1657769 ILMN_1786734 ILMN_1815733 ILMN_2318430 PH_hs_0030187 RNA33538\|snoRNA_scaRNA_134_126 TC14000797.hg TC14000798.hg U49436_at g4503542_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-72616] EIF5 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12769737] UCSC:P55010 EIF5 [ReferenceDNASequence:12116009] OMIM:601710 EIF5 [ReferenceDNASequence:12101404] NCBI Gene:1983 EIF5 [ReferenceDNASequence:12017311] Monarch:1983 EIF5 [ReferenceDNASequence:11923955] KEGG:hsa:1983 EIF5 [ReferenceDNASequence:11825600] HGNC:3299 EIF5 [ReferenceDNASequence:11441753] dbSNP Gene:1983 EIF5 [ReferenceDNASequence:11422525] CTD Gene:1983 EIF5 [ReferenceDNASequence:11404094] COSMIC - genes:EIF5 EIF5 [ReferenceDNASequence:11387522] BioGPS Gene:1983 EIF5 [ReferenceDNASequence:ensembl:ENSG00000100664] ENSEMBL:ENSG00000100664 EIF5
referenceTranscript	[ReferenceRNASequence:12659003] RefSeq:NM_183004.4 EIF5 [ReferenceRNASequence:12659002] RefSeq:NM_001969.4 EIF5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	IF5_HUMAN Q53XB3 Q9H5N2 Q9UG48
sequenceLength	431
species	[Species:48887] Homo sapiens
stId	uniprot:P55010
url	http://purl.uniprot.org/uniprot/P55010

Referrals

(interactor)	[UndirectedInteraction:11277725] UniProt:P55010 <-> UniProt:O14863 (IntAct) [UndirectedInteraction:11277723] UniProt:P55010 <-> UniProt:Q9UNI6 (IntAct) [UndirectedInteraction:11226279] UniProt:P42858 <-> UniProt:P55010 (IntAct) [UndirectedInteraction:11156619] UniProt:P47813 <-> UniProt:P55010 (IntAct) [UndirectedInteraction:11148759] UniProt:P13569 <-> UniProt:P55010 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-72616] EIF5 [cytosol]