UniProt:P54274 TERF1

chain
  • initiator methionine:1
  • chain:2-439
checksum AB548E7D3124A211
comment
  • FUNCTION Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length (PubMed:31595153). Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.SUBUNIT Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with RLIM (via N-terminus). Interacts with FBXO4. Interaction with TINF2 protects against interaction with FBXO4 and subsequent polyubiquitination and proteasomal degradation. Interacts with GNL3L; this interaction promotes homodimerization. Interacts with TIN2. Interacts with RTEL1. Interactions with GNL3L and TIN2 are mutually exclusive. Interacts with CCDC79/TERB1 (By similarity). Interacts with TRIOBP isoform 1; mediates TERF1 localization to the centrosome (PubMed:24692559).INTERACTION Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle (PubMed:11943150). Colocalizes with TRIOBP isoform 1 at the telomeres in interphase (PubMed:24692559).ALTERNATIVE PRODUCTS Highly expressed and ubiquitous. Isoform Pin2 predominates.INDUCTION Expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis.DOMAIN The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.DOMAIN The TRFH dimerization region mediates the interaction with TINF2.DOMAIN The HTH domain is an independent structural unit and mediates binding to telomeric DNA.PTM Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.PTM ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.PTM Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.
crossReference
databaseName UniProt
dbId 69638
description
  • recommendedName: Telomeric repeat-binding factor 1 alternativeName: NIMA-interacting protein 2 alternativeName: TTAGGG repeat-binding factor 1 alternativeName: Telomeric protein Pin2/TRF1
displayName UniProt:P54274 TERF1
geneName
  • TERF1
  • PIN2
  • TRBF1
  • TRF
  • TRF1
identifier P54274
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • ADP-ribosylation
  • Alternative splicing
  • Cell cycle
  • Cell division
  • Chromosome
  • Cytoplasm
  • Cytoskeleton
  • Direct protein sequencing
  • DNA-binding
  • Isopeptide bond
  • Mitosis
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Telomere
  • Ubl conjugation
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • TERF1
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TERF1_HUMAN
  • A7XP29
  • Q15553
  • Q8NHT6
  • Q93029
sequenceLength 439
species [Species:48887] Homo sapiens
stId uniprot:P54274
url http://purl.uniprot.org/uniprot/P54274

Referrals

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