Reactome | UniProt:P53992 SEC24C

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UniProt:P53992 SEC24C Show undefined attributes

chain	chain:1-1094
checksum	5E308E4B8E596ECE
comment	FUNCTION Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:18843296, PubMed:20427317). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).SUBUNIT COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1 (PubMed:10075675, PubMed:10214955, PubMed:17499046). Interacts with TMED2 and TMED10 (PubMed:20427317). Interacts with GOSR2 (via IxM motif) and STX5 (via IxM motif); recruits GOSR2 and STX5 into COPII-coated vesicles (PubMed:18843296). Interacts with DDHD1 (PubMed:17428803). Interacts with STING1; promoting STING1 translocation to the COPII vesicles (PubMed:30842662).INTERACTION Ubiquitous.SIMILARITY Belongs to the SEC23/SEC24 family. SEC24 subfamily.
crossReference	[DatabaseIdentifier:11445908] ENSEMBL:ENSG00000176986 [DatabaseIdentifier:11533031] ENSEMBL:ENSP00000321845 [DatabaseIdentifier:11533030] ENSEMBL:ENSP00000343405 [DatabaseIdentifier:11655729] ENSEMBL:ENST00000339365 [DatabaseIdentifier:11655730] ENSEMBL:ENST00000345254 [DatabaseIdentifier:11784440] GeneCards:SEC24C [DatabaseIdentifier:11799912] GlyGen:P53992 [DatabaseIdentifier:11837537] HPA:ENSG00000176986-SEC24C [DatabaseIdentifier:12122032] OpenTargets:ENSG00000176986 [DatabaseIdentifier:12136613] Orphanet:SEC24C [DatabaseIdentifier:12157859] PDB:8CL3 [DatabaseIdentifier:12157860] PDB:6PU1 [DatabaseIdentifier:12157858] PDB:3EH2 [DatabaseIdentifier:12240093] PRO:P53992 [DatabaseIdentifier:12282356] Pharos - Targets:P53992 [DatabaseIdentifier:12312172] RefSeq:XP_054223205.1 [DatabaseIdentifier:12312171] RefSeq:XP_054223204.1 [DatabaseIdentifier:12312173] RefSeq:NP_004913.2 [DatabaseIdentifier:12312174] RefSeq:XP_047281990.1 [DatabaseIdentifier:12312170] RefSeq:XP_047281989.1 [DatabaseIdentifier:12312169] RefSeq:NP_940999.1
databaseName	UniProt
dbId	64016
description	recommendedName: fullName evidence="13"Protein transport protein Sec24C alternativeName: SEC24-related protein C
displayName	UniProt:P53992 SEC24C
geneName	SEC24C KIAA0079
identifier	P53992
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cytoplasm Cytoplasmic vesicle Endoplasmic reticulum ER-Golgi transport Membrane Metal-binding Phosphoprotein Protein transport Proteomics identification Reference proteome Transport Zinc
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	SEC24C
otherIdentifier	11718639_a_at 11753200_a_at 11755383_a_at 16706082 202361_PM_at 202361_at 3251849 3251850 3251851 3251852 3251853 3251854 3251856 3251857 3251858 3251859 3251860 3251861 3251862 3251863 3251864 3251865 3251866 3251867 3251868 3251869 3251871 3251872 3251873 3251874 3251875 3251876 3251878 3251879 3251881 3251882 3251883 3251885 3251887 3251888 3251889 3251890 3251891 3251892 3251893 3251894 3251895 3251896 3251897 3251898 3251899 3251900 3251901 3251902 3251903 3251904 3251905 3251906 38117_at 7928369 7928395 9632 A_14_P104672 A_14_P115408 A_14_P200272 A_24_P255338 A_33_P3317123 D38555_at GE57198 GO:0000149 GO:0001701 GO:0005515 GO:0005737 GO:0005783 GO:0005789 GO:0005829 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0030127 GO:0031410 GO:0046872 GO:0048856 GO:0070971 GO:0090110 HMNXSV003000764 HMNXSV003043041 ILMN_1676600 ILMN_1706758 PH_hs_0031363 TC10000468.hg g4758633_3p_at g4758633_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-203987] SEC24C [endoplasmic reticulum membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-203988] SEC24C [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-204026] SEC24C [ER to Golgi transport vesicle membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5694551] p-SEC24C [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000176986] ENSEMBL:ENSG00000176986 SEC24C [ReferenceDNASequence:12722628] UCSC:P53992 SEC24C [ReferenceDNASequence:11311568] BioGPS Gene:9632 SEC24C [ReferenceDNASequence:11397465] COSMIC - genes:SEC24C SEC24C [ReferenceDNASequence:11408376] CTD Gene:9632 SEC24C [ReferenceDNASequence:11434155] dbSNP Gene:9632 SEC24C [ReferenceDNASequence:11816065] HGNC:10705 SEC24C [ReferenceDNASequence:11855225] KEGG:hsa:9632 SEC24C [ReferenceDNASequence:11941357] Monarch:9632 SEC24C [ReferenceDNASequence:12025450] NCBI Gene:9632 SEC24C [ReferenceDNASequence:12107684] OMIM:607185 SEC24C
referenceTranscript	[ReferenceRNASequence:12494240] RefSeq:XM_047426034.1 SEC24C [ReferenceRNASequence:12494242] RefSeq:XM_054367230.1 SEC24C [ReferenceRNASequence:12494243] RefSeq:NM_004922.3 SEC24C [ReferenceRNASequence:12494239] RefSeq:NM_198597.3 SEC24C [ReferenceRNASequence:12494238] RefSeq:XM_054367229.1 SEC24C [ReferenceRNASequence:12494241] RefSeq:XM_047426033.1 SEC24C
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SC24C_HUMAN B4DZT4 Q8WV25
sequenceLength	1094
species	[Species:48887] Homo sapiens
stId	uniprot:P53992
url	http://purl.uniprot.org/uniprot/P53992

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-203987] SEC24C [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-203988] SEC24C [cytosol] [EntityWithAccessionedSequence:R-HSA-204026] SEC24C [ER to Golgi transport vesicle membrane] [EntityWithAccessionedSequence:R-HSA-5694551] p-SEC24C [cytosol]
(referenceSequence)	[ModifiedResidue:5694550] phosphorylated residue at unknown position
(interactor)	[UndirectedInteraction:11140961] UniProt:P53992 <-> UniProt:Q15436 (IntAct) [UndirectedInteraction:11140965] UniProt:P53992 <-> UniProt:Q15437 (IntAct) [UndirectedInteraction:11140969] UniProt:P53992 <-> UniProt:P00540 (IntAct) [UndirectedInteraction:11140971] UniProt:P53992 <-> UniProt:P20081 (IntAct) [UndirectedInteraction:11140975] UniProt:P53992 <-> UniProt:P53829 (IntAct) [UndirectedInteraction:11140977] UniProt:P53992 <-> UniProt:O43516 (IntAct) [UndirectedInteraction:11140979] UniProt:P53992 <-> UniProt:Q96PV0 (IntAct) [UndirectedInteraction:11140981] UniProt:P53992 <-> UniProt:P13569 (IntAct)