UniProt:P53611 RABGGTB

chain
  • initiator methionine:1
  • chain:2-331
checksum 37A8A6329146C49B
comment
  • FUNCTION Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A (PubMed:7991565). Catalytic subunit of the geranylgeranyl transferase type 3 (GGTase-3) complex (PubMed:31209342, PubMed:32128853). The GGTase-3 complex geranylgeranylates and targets FBXL2 to the cellular membranes, where FBXL2 forms part of the E3 ubiquitin-protein ligase complex SCF(FBXL2) that mediates the degradation of membrane-anchored proteins (PubMed:31209342, PubMed:32128853). The GGTase-3 complex geranylgeranylates Golgi v-SNARE protein YKT6 at 'Cys-194' and this prenylation is required for Golgi SNARE complex assembly (PubMed:32128853).CATALYTIC ACTIVITY geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphateCOFACTOR Binds 1 zinc ion per subunit.ACTIVITY REGULATION The enzymatic reaction requires the aid of a Rab escort protein (also called component A).SUBUNIT Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding (PubMed:18532927). The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp) (PubMed:18532927). The CHM:RGGT:Rab complex is destabilized by GGpp (PubMed:18532927). Interaction of RABGGTB with prenylated PTP4A2 precludes its association with RABGGTA and inhibits enzyme activity (PubMed:11447212). Part of the GGTase-3 complex, composed of PTAR1 and RABGGTB; this complex geranylgeranylates FBXL2 and YKT6 (PubMed:31209342, PubMed:32128853). Interacts with CHODL (By similarity). Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at 'Thr-72' disrupts this interaction (PubMed:26824392).INTERACTION Belongs to the protein prenyltransferase subunit beta family.ONLINE INFORMATION Rab geranylgeranyltransferase entry
crossReference
databaseName UniProt
dbId 61636
description
  • recommendedName: Geranylgeranyl transferase type-2 subunit beta ecNumber evidence="8"2.5.1.60 alternativeName: Geranylgeranyl transferase type II subunit beta shortName: GGTase-II-beta alternativeName: Rab geranyl-geranyltransferase subunit beta shortName: Rab GG transferase beta shortName: Rab GGTase beta alternativeName: Rab geranylgeranyltransferase subunit beta alternativeName: Type II protein geranyl-geranyltransferase subunit beta
displayName UniProt:P53611 RABGGTB
geneName
  • RABGGTB
  • GGTB
identifier P53611
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Metal-binding
  • Phosphoprotein
  • Prenyltransferase
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transferase
  • Zinc
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • RABGGTB
otherIdentifier
  • 11724300_a_at
  • 11757294_x_at
  • 16666268
  • 17118662
  • 17118664
  • 17118666
  • 209180_PM_at
  • 209180_at
  • 209181_PM_s_at
  • 209181_s_at
  • 213704_PM_at
  • 213704_at
  • 2342622
  • 2342623
  • 2342625
  • 2342627
  • 2342628
  • 2342629
  • 2342630
  • 2342631
  • 2342632
  • 2342633
  • 2342634
  • 2342635
  • 2342636
  • 2342637
  • 2342638
  • 2342639
  • 2342640
  • 2342641
  • 2342642
  • 2342643
  • 2342644
  • 2342645
  • 2342646
  • 2342647
  • 2342648
  • 2342649
  • 2342650
  • 2342651
  • 2342652
  • 2342653
  • 2342654
  • 2342655
  • 2342656
  • 2342658
  • 2342659
  • 2342660
  • 2342662
  • 37703_at
  • 3983311
  • 5876
  • 781_at
  • 7902382
  • 7902396
  • 7902398
  • 7902400
  • A_14_P128168
  • A_21_P0000289
  • A_21_P0000372
  • A_23_P85371
  • A_24_P336705
  • A_33_P3311618
  • GE60250
  • GO:0003824
  • GO:0004659
  • GO:0004661
  • GO:0004663
  • GO:0005515
  • GO:0005737
  • GO:0005829
  • GO:0005886
  • GO:0005968
  • GO:0006888
  • GO:0007601
  • GO:0008270
  • GO:0008318
  • GO:0016192
  • GO:0016740
  • GO:0018344
  • GO:0031267
  • GO:0036211
  • GO:0046872
  • GO:0050877
  • GO:0140096
  • HMNXSV003008566
  • HMNXSV003013751
  • HMNXSV003037933
  • ILMN_1790354
  • ILMN_2163796
  • PH_hs_0004556
  • RNA33617|snoRNA_scaRNA_213_83
  • RNA33668|snoRNA_scaRNA_264_78
  • TC01000777.hg
  • X98001_at
  • g1216503_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PGTB2_HUMAN
  • Q92697
sequenceLength 331
species [Species:48887] Homo sapiens
stId uniprot:P53611
url http://purl.uniprot.org/uniprot/P53611

Referrals

(referenceEntity)
(interactor)
Cite Us!