Reactome | UniProt:P53091 MCM6

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UniProt:P53091 MCM6 Show undefined attributes

chain	chain:1-1017
checksum	03AB793134E64A50
comment	FUNCTION Acts as a component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Required for the entry in S phase and for cell division.CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)SUBUNIT Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5; loaded onto DNA, forms a head-head double hexamer. Interacts with MCM10.INTERACTION Present with 13400 molecules/cell in log phase SD medium.MISCELLANEOUS Early fractionation of eukaryotic MCM proteins yielded a variety of dimeric, trimeric and tetrameric complexes with unclear biological significance. Specifically a MCM467 subcomplex is shown to have in vitro helicase activity which is inhibited by the MCM2 subunit. The MCM2-7 hexamer is the proposed physiological active complex.SIMILARITY Belongs to the MCM family.
crossReference	[DatabaseIdentifier:12142054] PDB:5U8S [DatabaseIdentifier:12390567] RefSeq:NP_011314.2 [DatabaseIdentifier:12275960] PRO:P53091 [DatabaseIdentifier:12142069] PDB:3JC7 [DatabaseIdentifier:12142059] PDB:9E2W [DatabaseIdentifier:12149028] PDB:7PT6 [DatabaseIdentifier:12142077] PDB:8KG6 [DatabaseIdentifier:12142052] PDB:7PMN [DatabaseIdentifier:12149032] PDB:6SKO [DatabaseIdentifier:12142057] PDB:6PTJ [DatabaseIdentifier:12149039] PDB:3JA8 [DatabaseIdentifier:12142062] PDB:7PMK [DatabaseIdentifier:12142004] PDB:9GJP [DatabaseIdentifier:12142053] PDB:8W7S [DatabaseIdentifier:12149033] PDB:6WGF [DatabaseIdentifier:12142065] PDB:8W7M [DatabaseIdentifier:12142078] PDB:8KG8 [DatabaseIdentifier:12149044] PDB:7Z13 [DatabaseIdentifier:12141991] PDB:6WGG [DatabaseIdentifier:12142076] PDB:8B9C [DatabaseIdentifier:12149031] PDB:7W8G [DatabaseIdentifier:12142073] PDB:8B9A [DatabaseIdentifier:12142070] PDB:6U0M [DatabaseIdentifier:12149035] PDB:8RIG [DatabaseIdentifier:12142055] PDB:5U8T [DatabaseIdentifier:12149042] PDB:7P5Z [DatabaseIdentifier:12142064] PDB:8P63 [DatabaseIdentifier:12141992] PDB:6WGI [DatabaseIdentifier:12142063] PDB:8P62 [DatabaseIdentifier:12142060] PDB:6PTO [DatabaseIdentifier:12141985] PDB:9BCX [DatabaseIdentifier:12149037] PDB:8RIF [DatabaseIdentifier:11482645] ENSEMBL:YGL201C [DatabaseIdentifier:11584338] ENSEMBL:YGL201C [DatabaseIdentifier:11707037] ENSEMBL:YGL201C_mRNA [DatabaseIdentifier:11850111] IntEnz:3.6.4.12 [DatabaseIdentifier:12142066] PDB:3JC5 [DatabaseIdentifier:12149029] PDB:7PT7 [DatabaseIdentifier:12149036] PDB:5XF8 [DatabaseIdentifier:12142071] PDB:8XGC [DatabaseIdentifier:12142003] PDB:9GM5 [DatabaseIdentifier:12142056] PDB:9E2X [DatabaseIdentifier:12142079] PDB:8KG9 [DatabaseIdentifier:12142075] PDB:6HV9 [DatabaseIdentifier:12141997] PDB:9GJW [DatabaseIdentifier:12149041] PDB:7V3U [DatabaseIdentifier:12149034] PDB:7QHS [DatabaseIdentifier:12141990] PDB:5V8F [DatabaseIdentifier:12142072] PDB:6SKL [DatabaseIdentifier:12149027] PDB:6EYC [DatabaseIdentifier:12149038] PDB:5BK4 [DatabaseIdentifier:12142068] PDB:8P5E [DatabaseIdentifier:12142067] PDB:3JC6 [DatabaseIdentifier:12149040] PDB:7V3V [DatabaseIdentifier:12149043] PDB:6F0L [DatabaseIdentifier:12142061] PDB:6PTN [DatabaseIdentifier:12142058] PDB:9E2Y [DatabaseIdentifier:12142006] PDB:6RQC [DatabaseIdentifier:12149030] PDB:7P30 [DatabaseIdentifier:12142074] PDB:8B9B
databaseName	UniProt
dbId	94963
description	recommendedName: DNA replication licensing factor MCM6 ecNumber: 3.6.4.12 alternativeName: Minichromosome maintenance protein 6
displayName	UniProt:P53091 MCM6
geneName	MCM6 YGL201C
identifier	P53091
isSequenceChanged	false
keyword	3D-structure ATP-binding Cell cycle DNA replication DNA-binding Helicase Hydrolase Nucleotide-binding Nucleus Phosphoprotein Reference proteome
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	MCM6
otherIdentifier	852673 GO:0000166 GO:0000727 GO:0003674 GO:0003677 GO:0003678 GO:0003688 GO:0003697 GO:0004386 GO:0005515 GO:0005524 GO:0005575 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0006279 GO:0006281 GO:0006310 GO:0008150 GO:0008270 GO:0009378 GO:0016787 GO:0016887 GO:0017116 GO:0031261 GO:0031298 GO:0042555 GO:0043138 GO:0043167 GO:0043596 GO:0071162 GO:0097373 GO:0140657 GO:1902969 GO:1990518
physicalEntity	[EntityWithAccessionedSequence:R-SCE-68553] MCM6 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-169504] yMcm6 [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11348100] BioGPS Gene:852673 MCM6 [ReferenceDNASequence:12743577] UCSC:P53091 MCM6 [ReferenceDNASequence:11888080] KEGG:sce:YGL201C MCM6 [ReferenceDNASequence:11977889] Monarch:852673 MCM6 [ReferenceDNASequence:12061982] NCBI Gene:852673 MCM6
referenceTranscript	[ReferenceRNASequence:12572326] RefSeq:NM_001181066.1 MCM6
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MCM6_YEAST D6VTV3 Q870M9
sequenceLength	1017
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P53091
url	http://purl.uniprot.org/uniprot/P53091

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