Reactome | UniProt:P52757 CHN2

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UniProt:P52757 CHN2 Show undefined attributes

chain	chain:1-468
checksum	63254958E0B5804C
comment	FUNCTION GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.ACTIVITY REGULATION In the inactive state, the N terminus protrudes into the active site of the Rho-GAP domain, sterically blocking Rac binding. Phospholipid binding to the Phorbol-ester/DAG-type zinc-finger/C1 domain triggers the cooperative dissociation of these interactions, allowing the N-terminus to move out of the active site and thereby activating the enzyme.INTERACTION Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:11467729] ENSEMBL:ENSG00000106069 [DatabaseIdentifier:12816439] ZINC target:P52757 [DatabaseIdentifier:12813041] ZINC - Substances:CHIO_HUMAN [DatabaseIdentifier:11563623] ENSEMBL:ENSP00000516243 [DatabaseIdentifier:11563625] ENSEMBL:ENSP00000394284 [DatabaseIdentifier:11563624] ENSEMBL:ENSP00000222792 [DatabaseIdentifier:11563626] ENSEMBL:ENSP00000486515 [DatabaseIdentifier:11686325] ENSEMBL:ENST00000412711 [DatabaseIdentifier:11686322] ENSEMBL:ENST00000222792 [DatabaseIdentifier:11686324] ENSEMBL:ENST00000467441 [DatabaseIdentifier:11686323] ENSEMBL:ENST00000421775 [DatabaseIdentifier:11784721] GeneCards:CHN2 [DatabaseIdentifier:11832565] HMDB Protein:HMDBP10959 [DatabaseIdentifier:11837814] HPA:ENSG00000106069-CHN2 [DatabaseIdentifier:12122312] OpenTargets:ENSG00000106069 [DatabaseIdentifier:12160136] PDB:1XA6 [DatabaseIdentifier:12260779] PRO:P52757 [DatabaseIdentifier:12282633] Pharos - Targets:P52757 [DatabaseIdentifier:12356441] RefSeq:NP_001279999.1 [DatabaseIdentifier:12356445] RefSeq:NP_001280004.1 [DatabaseIdentifier:12356447] RefSeq:NP_001280006.1 [DatabaseIdentifier:12356438] RefSeq:NP_001280000.1 [DatabaseIdentifier:12356439] RefSeq:NP_001280002.1 [DatabaseIdentifier:12356443] RefSeq:NP_001280009.1 [DatabaseIdentifier:12356446] RefSeq:NP_004058.1 [DatabaseIdentifier:12356444] RefSeq:NP_001035025.1 [DatabaseIdentifier:12356440] RefSeq:NP_001280008.1 [DatabaseIdentifier:12356448] RefSeq:NP_001280005.1 [DatabaseIdentifier:12356442] RefSeq:NP_001280007.1
databaseName	UniProt
dbId	404336
description	recommendedName: Beta-chimaerin alternativeName: Beta-chimerin alternativeName: Rho GTPase-activating protein 3
displayName	UniProt:P52757 CHN2
geneName	CHN2 ARHGAP3 BCH
identifier	P52757
isSequenceChanged	false
keyword	3D-structure Alternative splicing GTPase activation Membrane Metal-binding Proteomics identification Reference proteome SH2 domain Zinc Zinc-finger
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	CHN2
otherIdentifier	1124 11721936_a_at 11721937_a_at 11745697_a_at 11748284_a_at 11751748_a_at 11753540_a_at 11753541_x_at 11753605_a_at 11753765_a_at 11753766_x_at 11757516_s_at 207486_PM_x_at 207486_x_at 211419_PM_s_at 211419_s_at 213385_PM_at 213385_at 2994836 2994837 2994838 2994846 2994847 2994848 2994849 2994871 2994886 2994888 2994889 2994890 2994899 2994902 2994903 2994904 2994905 2994907 2994908 2994909 2994910 2994948 2994949 2994950 2994951 2994952 2994953 2994954 2994960 2994961 2994962 2994963 2994965 2994966 2994967 2994968 2994969 33244_at 8132013 A_14_P100549 A_14_P108386 A_14_P131541 A_24_P277875 A_33_P3237891 A_33_P3237894 A_33_P3237899 A_33_P3287348 A_33_P3353027 GE81345 GO:0001675 GO:0005096 GO:0005515 GO:0005829 GO:0007165 GO:0008270 GO:0016020 GO:0022414 GO:0043547 GO:0045202 GO:0046872 GO:0051056 GO:0098772 HMNXSV003014324 HMNXSV003022348 HMNXSV003030559 HMNXSV003053196 Hs.286055.2.S1_3p_at ILMN_1732716 ILMN_1774110 ILMN_2292187 ILMN_2403237 PH_hs_0019403 U07223_at g4757979_3p_a_at p25471
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2980572] CHN2 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000106069] ENSEMBL:ENSG00000106069 CHN2 [ReferenceDNASequence:12735693] UCSC:P52757 CHN2 [ReferenceDNASequence:11332354] BioGPS Gene:1124 CHN2 [ReferenceDNASequence:11399030] COSMIC - genes:CHN2 CHN2 [ReferenceDNASequence:11408817] CTD Gene:1124 CHN2 [ReferenceDNASequence:11435945] dbSNP Gene:1124 CHN2 [ReferenceDNASequence:11816346] HGNC:1944 CHN2 [ReferenceDNASequence:11874019] KEGG:hsa:1124 CHN2 [ReferenceDNASequence:11962143] Monarch:1124 CHN2 [ReferenceDNASequence:12046236] NCBI Gene:1124 CHN2 [ReferenceDNASequence:12107929] OMIM:602857 CHN2
referenceTranscript	[ReferenceRNASequence:12538290] RefSeq:NM_001293071.1 CHN2 [ReferenceRNASequence:12538292] RefSeq:NM_001293070.1 CHN2 [ReferenceRNASequence:12538284] RefSeq:NM_001039936.3 CHN2 [ReferenceRNASequence:12538289] RefSeq:NM_001293079.1 CHN2 [ReferenceRNASequence:12538285] RefSeq:NM_001293076.2 CHN2 [ReferenceRNASequence:12538286] RefSeq:NM_001293077.1 CHN2 [ReferenceRNASequence:12538287] RefSeq:NM_004067.4 CHN2 [ReferenceRNASequence:12538293] RefSeq:NM_001293075.2 CHN2 [ReferenceRNASequence:12538291] RefSeq:NM_001293073.2 CHN2 [ReferenceRNASequence:12538294] RefSeq:NM_001293080.2 CHN2 [ReferenceRNASequence:12538288] RefSeq:NM_001293078.1 CHN2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CHIO_HUMAN A4D1A2 B3VCF1 B3VCF2 B3VCF3 B3VCF7 B3VCG1 C9J7B0 E9PGE0 F8QPL9 Q2M203 Q75MM2
sequenceLength	468
species	[Species:48887] Homo sapiens
stId	uniprot:P52757
url	http://purl.uniprot.org/uniprot/P52757

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2980572] CHN2 [cytosol]
(interactor)	[UndirectedInteraction:11204099] UniProt:P63000 <-> UniProt:P52757 (IntAct) [UndirectedInteraction:11215191] UniProt:O43639 <-> UniProt:P52757 (IntAct) [UndirectedInteraction:11275321] UniProt:P16333 <-> UniProt:P52757 (IntAct)

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