Reactome | UniProt:P52657 GTF2A2

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UniProt:P52657 GTF2A2 Show undefined attributes

chain	chain:1-109
checksum	938E7DC8B9982AE8
comment	FUNCTION TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.SUBUNIT TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma (By similarity). It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12) (By similarity). Interacts with NCOA6 general coactivator (PubMed:10567404). TFIIA forms a complex with TBP (PubMed:11030333). Interacts with HSF1 (via transactivation domain) (PubMed:11005381). Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.SUBUNIT (Microbial infection) Interacts with SV40 Large T antigen.INTERACTION Belongs to the TFIIA subunit 2 family.
crossReference	[DatabaseIdentifier:12138282] PDB:5IY7 [DatabaseIdentifier:12355059] RefSeq:NP_001307858.1 [DatabaseIdentifier:12355057] RefSeq:NP_004483.1 [DatabaseIdentifier:12355058] RefSeq:NP_001307859.1 [DatabaseIdentifier:12282347] Pharos - Targets:P52657 [DatabaseIdentifier:12260321] PRO:P52657 [DatabaseIdentifier:12157814] PDB:7EGD [DatabaseIdentifier:12139980] PDB:7ENC [DatabaseIdentifier:12140148] PDB:8WAK [DatabaseIdentifier:12139976] PDB:8GXS [DatabaseIdentifier:12140178] PDB:7NVU [DatabaseIdentifier:12140172] PDB:7EGB [DatabaseIdentifier:12139982] PDB:7ENA [DatabaseIdentifier:12157810] PDB:1NVP [DatabaseIdentifier:12140153] PDB:8WAO [DatabaseIdentifier:12140179] PDB:8S51 [DatabaseIdentifier:12139981] PDB:7NVR [DatabaseIdentifier:12139977] PDB:8GXQ [DatabaseIdentifier:12140171] PDB:7EGA [DatabaseIdentifier:12138276] PDB:5IYD [DatabaseIdentifier:12140174] PDB:7NVY [DatabaseIdentifier:12138281] PDB:5IY8 [DatabaseIdentifier:12140170] PDB:8BVW [DatabaseIdentifier:12138275] PDB:5IYA [DatabaseIdentifier:12140147] PDB:8WAL [DatabaseIdentifier:12140156] PDB:7EG7 [DatabaseIdentifier:12140145] PDB:8WAS [DatabaseIdentifier:12140151] PDB:8WAQ [DatabaseIdentifier:12140161] PDB:7ZX7 [DatabaseIdentifier:12140164] PDB:8BZ1 [DatabaseIdentifier:12140149] PDB:8WAP [DatabaseIdentifier:12138288] PDB:6O9L [DatabaseIdentifier:12140144] PDB:8WAR [DatabaseIdentifier:12140163] PDB:7ZX8 [DatabaseIdentifier:11467149] ENSEMBL:ENSG00000140307 [DatabaseIdentifier:11562923] ENSEMBL:ENSP00000379373 [DatabaseIdentifier:11562925] ENSEMBL:ENSP00000379372 [DatabaseIdentifier:11562924] ENSEMBL:ENSP00000379375 [DatabaseIdentifier:11685624] ENSEMBL:ENST00000396060 [DatabaseIdentifier:11685623] ENSEMBL:ENST00000396061 [DatabaseIdentifier:11685622] ENSEMBL:ENST00000396063 [DatabaseIdentifier:11784431] GeneCards:GTF2A2 [DatabaseIdentifier:11837528] HPA:ENSG00000140307-GTF2A2 [DatabaseIdentifier:12122023] OpenTargets:ENSG00000140307 [DatabaseIdentifier:12138280] PDB:5IY6 [DatabaseIdentifier:12140175] PDB:7NVZ [DatabaseIdentifier:12140162] PDB:8BYQ [DatabaseIdentifier:12140157] PDB:7EG8 [DatabaseIdentifier:12138290] PDB:7LBM [DatabaseIdentifier:12140176] PDB:8S52 [DatabaseIdentifier:12138285] PDB:5IY9 [DatabaseIdentifier:12138273] PDB:5IYB [DatabaseIdentifier:12138278] PDB:5IYC [DatabaseIdentifier:12157813] PDB:5M4S [DatabaseIdentifier:12140177] PDB:7NW0 [DatabaseIdentifier:12140154] PDB:7EDX [DatabaseIdentifier:12140152] PDB:8WAN [DatabaseIdentifier:12140181] PDB:7NVT [DatabaseIdentifier:12140143] PDB:7ZWD [DatabaseIdentifier:12140146] PDB:8S5N [DatabaseIdentifier:12157812] PDB:7EGJ [DatabaseIdentifier:12140168] PDB:7EGC [DatabaseIdentifier:12140150] PDB:7ZWC [DatabaseIdentifier:12157815] PDB:6MZM [DatabaseIdentifier:12157809] PDB:5FUR [DatabaseIdentifier:12140180] PDB:7NVS [DatabaseIdentifier:12157811] PDB:7EGI [DatabaseIdentifier:12140173] PDB:7EG9 [DatabaseIdentifier:12140159] PDB:7ZXE
databaseName	UniProt
dbId	65534
description	recommendedName: Transcription initiation factor IIA subunit 2 alternativeName: General transcription factor IIA subunit 2 alternativeName: TFIIA p12 subunit shortName: TFIIA-12 shortName: TFIIAS alternativeName: Transcription initiation factor IIA gamma chain shortName: TFIIA-gamma
displayName	UniProt:P52657 GTF2A2
geneName	GTF2A2 TF2A2
identifier	P52657
isSequenceChanged	false
keyword	3D-structure Host-virus interaction Nucleus Proteomics identification Reference proteome Transcription Transcription regulation
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	GTF2A2
otherIdentifier	11723034_at 11723035_s_at 11754097_x_at 11757381_x_at 16810025 202678_PM_at 202678_at 230376_PM_at 230376_at 2958 3627043 3627044 3627045 3627046 3627047 3627048 3627050 3627051 3627052 3627053 3627054 3627055 3627056 3627057 3627058 3627061 3627063 3627064 3627065 3627070 37010_at 64672_at 7989315 869_at A_24_P270525 A_33_P3415957 GE58949 GO:0001091 GO:0005515 GO:0005634 GO:0005654 GO:0005669 GO:0005672 GO:0005829 GO:0006351 GO:0006355 GO:0006366 GO:0006367 GO:0016251 GO:0017025 GO:0042803 GO:0045944 GO:0046982 GO:0051123 GO:0060261 GO:0061629 GO:0065003 HMNXSV003007315 Hs.44324.0.A1_3p_at ILMN_1753719 PH_hs_0023416 TC15001501.hg U14193_at g4758485_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-65533] GTF2A2 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000140307] ENSEMBL:ENSG00000140307 GTF2A2 [ReferenceDNASequence:12735317] UCSC:P52657 GTF2A2 [ReferenceDNASequence:11331664] BioGPS Gene:2958 GTF2A2 [ReferenceDNASequence:11399012] COSMIC - genes:GTF2A2 GTF2A2 [ReferenceDNASequence:11408361] CTD Gene:2958 GTF2A2 [ReferenceDNASequence:11435922] dbSNP Gene:2958 GTF2A2 [ReferenceDNASequence:11816056] HGNC:4647 GTF2A2 [ReferenceDNASequence:11873406] KEGG:hsa:2958 GTF2A2 [ReferenceDNASequence:11961453] Monarch:2958 GTF2A2 [ReferenceDNASequence:12045546] NCBI Gene:2958 GTF2A2 [ReferenceDNASequence:12107675] OMIM:600519 GTF2A2
referenceTranscript	[ReferenceRNASequence:12536924] RefSeq:NM_004492.3 GTF2A2 [ReferenceRNASequence:12536923] RefSeq:NM_001320929.2 GTF2A2 [ReferenceRNASequence:12536922] RefSeq:NM_001320930.2 GTF2A2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	T2AG_HUMAN A8MYQ7 Q6FGB5
sequenceLength	109
species	[Species:48887] Homo sapiens
stId	uniprot:P52657
url	http://purl.uniprot.org/uniprot/P52657

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-65533] GTF2A2 [nucleoplasm]
(interactor)	[UndirectedInteraction:11262779] UniProt:P20226 <-> UniProt:P52657 (IntAct)

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