Reactome | UniProt:P52655 GTF2A1

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UniProt:P52655 GTF2A1 Show undefined attributes

chain	initiator methionine:1 chain:2-376 chain:2-274 chain:275-376
checksum	4BAE1853E7E89218
comment	FUNCTION TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.SUBUNIT TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). TFIIA forms a complex with TBP. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.INTERACTION The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation.SIMILARITY Belongs to the TFIIA subunit 1 family.
crossReference	[DatabaseIdentifier:12140175] PDB:7NVZ [DatabaseIdentifier:12355065] RefSeq:NP_056943.1 [DatabaseIdentifier:12355066] RefSeq:NP_001265869.1 [DatabaseIdentifier:12355064] RefSeq:NP_963889.1 [DatabaseIdentifier:12282349] Pharos - Targets:P52655 [DatabaseIdentifier:12260324] PRO:P52655 [DatabaseIdentifier:12139981] PDB:7NVR [DatabaseIdentifier:12138280] PDB:5IY6 [DatabaseIdentifier:12140164] PDB:8BZ1 [DatabaseIdentifier:12138278] PDB:5IYC [DatabaseIdentifier:12157811] PDB:7EGI [DatabaseIdentifier:12140161] PDB:7ZX7 [DatabaseIdentifier:12138276] PDB:5IYD [DatabaseIdentifier:12140163] PDB:7ZX8 [DatabaseIdentifier:12138282] PDB:5IY7 [DatabaseIdentifier:12140159] PDB:7ZXE [DatabaseIdentifier:12139977] PDB:8GXQ [DatabaseIdentifier:12140162] PDB:8BYQ [DatabaseIdentifier:12140168] PDB:7EGC [DatabaseIdentifier:12140176] PDB:8S52 [DatabaseIdentifier:12140170] PDB:8BVW [DatabaseIdentifier:12140172] PDB:7EGB [DatabaseIdentifier:12157815] PDB:6MZM [DatabaseIdentifier:12140171] PDB:7EGA [DatabaseIdentifier:12140179] PDB:8S51 [DatabaseIdentifier:12140173] PDB:7EG9 [DatabaseIdentifier:12138281] PDB:5IY8 [DatabaseIdentifier:12157812] PDB:7EGJ [DatabaseIdentifier:12140181] PDB:7NVT [DatabaseIdentifier:12140180] PDB:7NVS [DatabaseIdentifier:12140177] PDB:7NW0 [DatabaseIdentifier:12138285] PDB:5IY9 [DatabaseIdentifier:12138288] PDB:6O9L [DatabaseIdentifier:12157814] PDB:7EGD [DatabaseIdentifier:12139976] PDB:8GXS [DatabaseIdentifier:11467153] ENSEMBL:ENSG00000165417 [DatabaseIdentifier:11562930] ENSEMBL:ENSP00000452454 [DatabaseIdentifier:11562929] ENSEMBL:ENSP00000409492 [DatabaseIdentifier:11685629] ENSEMBL:ENST00000434192 [DatabaseIdentifier:11685628] ENSEMBL:ENST00000553612 [DatabaseIdentifier:11784433] GeneCards:GTF2A1 [DatabaseIdentifier:11799906] GlyGen:P52655 [DatabaseIdentifier:11837530] HPA:ENSG00000165417-GTF2A1 [DatabaseIdentifier:12122025] OpenTargets:ENSG00000165417 [DatabaseIdentifier:12140144] PDB:8WAR [DatabaseIdentifier:12140148] PDB:8WAK [DatabaseIdentifier:12140150] PDB:7ZWC [DatabaseIdentifier:12140153] PDB:8WAO [DatabaseIdentifier:12157810] PDB:1NVP [DatabaseIdentifier:12140152] PDB:8WAN [DatabaseIdentifier:12140147] PDB:8WAL [DatabaseIdentifier:12140149] PDB:8WAP [DatabaseIdentifier:12140154] PDB:7EDX [DatabaseIdentifier:12140151] PDB:8WAQ [DatabaseIdentifier:12140156] PDB:7EG7 [DatabaseIdentifier:12138290] PDB:7LBM [DatabaseIdentifier:12140143] PDB:7ZWD [DatabaseIdentifier:12140146] PDB:8S5N [DatabaseIdentifier:12140157] PDB:7EG8 [DatabaseIdentifier:12138273] PDB:5IYB [DatabaseIdentifier:12157809] PDB:5FUR [DatabaseIdentifier:12140145] PDB:8WAS [DatabaseIdentifier:12138275] PDB:5IYA [DatabaseIdentifier:12140178] PDB:7NVU [DatabaseIdentifier:12140174] PDB:7NVY [DatabaseIdentifier:12157813] PDB:5M4S
databaseName	UniProt
dbId	65532
description	recommendedName: Transcription initiation factor IIA subunit 1 alternativeName: General transcription factor IIA subunit 1 alternativeName: TFIIAL alternativeName: Transcription initiation factor TFIIA 42 kDa subunit shortName: TFIIA-42 component recommendedName: Transcription initiation factor IIA alpha chain alternativeName: TFIIA p35 subunit /component component recommendedName: Transcription initiation factor IIA beta chain alternativeName: TFIIA p19 subunit /component
displayName	UniProt:P52655 GTF2A1
geneName	GTF2A1 TF2A1
identifier	P52655
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative initiation Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	GTF2A1
otherIdentifier	11740965_a_at 16795351 206521_PM_s_at 206521_s_at 225433_PM_at 225433_at 2957 313_at 35495_at 3574073 3574075 3574076 3574077 3574078 3574079 3574080 3574081 3574084 3574085 3574086 3574087 3574088 3574089 3574090 3574091 3574092 3574093 3574096 3574097 3574103 3574104 3574105 3574106 3574107 3574108 44152_at 61385_at 63087_at 7980523 80266_at A_23_P65609 A_23_P65615 A_24_P201936 GE57095 GE86329 GE86330 GO:0000979 GO:0001091 GO:0003677 GO:0005515 GO:0005634 GO:0005654 GO:0005669 GO:0005672 GO:0005737 GO:0005829 GO:0006351 GO:0006355 GO:0006366 GO:0006367 GO:0016251 GO:0017025 GO:0045944 GO:0046982 GO:0051123 GO:0060261 GO:0061629 GO:0065003 GO:0097550 HMNXSV003041518 Hs.299542.0.S1_3p_at ILMN_1725247 ILMN_1732040 ILMN_2249552 PH_hs_0015446 PH_hs_0026727 PH_hs_0037756 TC14001368.hg TC14002101.hg g7706734_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-109767] GTF2A1(1-274) [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-109768] GTF2A1(275-376) [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000165417] ENSEMBL:ENSG00000165417 GTF2A1 [ReferenceDNASequence:12735321] UCSC:P52655 GTF2A1 [ReferenceDNASequence:11331667] BioGPS Gene:2957 GTF2A1 [ReferenceDNASequence:11399013] COSMIC - genes:GTF2A1 GTF2A1 [ReferenceDNASequence:11408365] CTD Gene:2957 GTF2A1 [ReferenceDNASequence:11435923] dbSNP Gene:2957 GTF2A1 [ReferenceDNASequence:11816058] HGNC:4646 GTF2A1 [ReferenceDNASequence:11873409] KEGG:hsa:2957 GTF2A1 [ReferenceDNASequence:11961456] Monarch:2957 GTF2A1 [ReferenceDNASequence:12045549] NCBI Gene:2957 GTF2A1 [ReferenceDNASequence:12107677] OMIM:600520 GTF2A1
referenceTranscript	[ReferenceRNASequence:12536931] RefSeq:NM_015859.4 GTF2A1 [ReferenceRNASequence:12536930] RefSeq:NM_001278940.1 GTF2A1 [ReferenceRNASequence:12536929] RefSeq:NM_201595.3 GTF2A1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	TF2AA_HUMAN Q3KNQ9
sequenceLength	376
species	[Species:48887] Homo sapiens
stId	uniprot:P52655
url	http://purl.uniprot.org/uniprot/P52655

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-109767] GTF2A1(1-274) [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-109768] GTF2A1(275-376) [nucleoplasm]
(interactor)	[UndirectedInteraction:11166965] UniProt:P62333 <-> UniProt:P52655 (IntAct) [UndirectedInteraction:11262785] UniProt:P20226 <-> UniProt:P52655 (IntAct) [UndirectedInteraction:11275391] UniProt:O15357 <-> UniProt:P52655 (IntAct) [UndirectedInteraction:11279861] UniProt:Q96CA5 <-> UniProt:P52655 (IntAct)

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