UniProt:P51813 BMX

chain
  • chain:1-675
checksum CB22382A3BD02599
comment
  • FUNCTION Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Binds 1 zinc ion per subunit.ACTIVITY REGULATION TEK and vascular endothelial growth factor receptor 1 (FLT1) stimulate BMX tyrosine kinase activity (By similarity). Activated by integrins through the mediation of PTK2/FAK1. Activated by TNF through the mediation of TNFRSF1B.SUBUNIT Interacts with BCAR1, CAV1, MYD88, PTK2/FAK1, RUFY1, RUFY2, STAT3, TIRAP and TNFRSF1B.INTERACTION Localizes to the edges of spreading cells when complexed with BCAR1.TISSUE SPECIFICITY Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.INDUCTION Activated by IL6/interleukin-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain.DOMAIN SH2 domain mediates interaction with RUFY1.PTM Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to activation and is required for STAT3 phosphorylation by BMX.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.SEQUENCE CAUTION Extended N-terminus.
crossReference
databaseName UniProt
dbId 50912
description
  • recommendedName: Cytoplasmic tyrosine-protein kinase BMX ecNumber: 2.7.10.2 alternativeName: Bone marrow tyrosine kinase gene in chromosome X protein alternativeName: Epithelial and endothelial tyrosine kinase shortName: ETK alternativeName: NTK38
displayName UniProt:P51813 BMX
geneName
  • BMX
identifier P51813
isSequenceChanged false
keyword
  • 3D-structure
  • Apoptosis
  • ATP-binding
  • Cell adhesion
  • Cytoplasm
  • Direct protein sequencing
  • Kinase
  • Metal-binding
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • SH2 domain
  • Stress response
  • Transferase
  • Tyrosine-protein kinase
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • BMX
otherIdentifier
  • 11729289_a_at
  • 17101698
  • 206464_PM_at
  • 206464_at
  • 3969803
  • 3969804
  • 3969810
  • 3969811
  • 3969812
  • 3969815
  • 3969816
  • 3969817
  • 3969818
  • 3969819
  • 3969820
  • 3969822
  • 3969823
  • 3969825
  • 3969826
  • 3969827
  • 3969828
  • 3969829
  • 3969830
  • 3969831
  • 3969832
  • 3969834
  • 3969835
  • 3969837
  • 3969842
  • 3969843
  • 660
  • 8166157
  • 962_at
  • A_23_P253602
  • A_24_P263144
  • GE78980
  • GO:0000166
  • GO:0002250
  • GO:0002376
  • GO:0003824
  • GO:0004672
  • GO:0004713
  • GO:0004715
  • GO:0005515
  • GO:0005524
  • GO:0005654
  • GO:0005737
  • GO:0005829
  • GO:0005886
  • GO:0006468
  • GO:0006629
  • GO:0006661
  • GO:0006915
  • GO:0007155
  • GO:0007165
  • GO:0007498
  • GO:0008270
  • GO:0016301
  • GO:0016740
  • GO:0032587
  • GO:0035556
  • GO:0046777
  • GO:0046872
  • GO:0048856
  • GO:0050853
  • GO:0140096
  • HMNXSV003027723
  • ILMN_1672307
  • ILMN_1759892
  • ILMN_1796138
  • PH_hs_0031113
  • TC0X000067.hg
  • X83107_at
  • g4502434_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BMX_HUMAN
  • A6NIH9
  • O60564
  • Q12871
sequenceLength 675
species [Species:48887] Homo sapiens
stId uniprot:P51813
url http://purl.uniprot.org/uniprot/P51813
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