UniProt:P51810 GPR143

chain
  • chain:1-404
checksum 20DEB20E80CC0E1D
comment
  • FUNCTION Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.SUBUNIT Interacts with heterotrimeric G(i) proteins. Interacts with ARRB1 and ARRB2. Interacts with MLANA.INTERACTION Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine (PubMed:18828673).TISSUE SPECIFICITY Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland.DOMAIN The cytoplasmic domain 3 and the C-terminus tail domain contain the lysosomal sorting signals and are necessary and sufficient for intracellular retention and delivery to lysosomal and melanosomal, respectively in melanocytic and non-melanocytic cells.PTM Glycosylated.PTM Phosphorylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the G-protein coupled receptor OA family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.ONLINE INFORMATION GPR143 mutations
crossReference
databaseName UniProt
dbId 60792
description
  • recommendedName: G-protein coupled receptor 143 alternativeName: Ocular albinism type 1 protein
displayName UniProt:P51810 GPR143
geneName
  • GPR143
  • OA1
identifier P51810
isSequenceChanged false
keyword
  • Albinism
  • Cell membrane
  • Disease variant
  • G-protein coupled receptor
  • Glycoprotein
  • Lysosome
  • Membrane
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Transducer
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType Protein
name
  • GPR143
otherIdentifier
  • 11726811_at
  • 17109020
  • 206696_PM_at
  • 206696_at
  • 36778_at
  • 3999160
  • 3999161
  • 3999162
  • 3999163
  • 3999164
  • 3999165
  • 3999169
  • 3999170
  • 3999171
  • 3999172
  • 3999173
  • 3999177
  • 3999178
  • 3999179
  • 3999186
  • 3999187
  • 3999188
  • 3999190
  • 3999191
  • 3999192
  • 3999200
  • 4935
  • 8171284
  • A_23_P45560
  • GE60417
  • GO:0004930
  • GO:0005515
  • GO:0005654
  • GO:0005737
  • GO:0005764
  • GO:0005765
  • GO:0005794
  • GO:0005886
  • GO:0006726
  • GO:0007165
  • GO:0007186
  • GO:0007200
  • GO:0007218
  • GO:0007601
  • GO:0016020
  • GO:0016324
  • GO:0016604
  • GO:0030054
  • GO:0032400
  • GO:0032402
  • GO:0032438
  • GO:0033162
  • GO:0035240
  • GO:0035643
  • GO:0042470
  • GO:0050877
  • GO:0072544
  • GO:0072545
  • GO:1902908
  • GO:1903056
  • HMNXSV003002978
  • HMNXSV003012253
  • ILMN_1756261
  • PH_hs_0004240
  • PH_hs_0035450
  • TC0X000851.hg
  • Z48804_at
  • g4557806_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • GP143_HUMAN
  • Q6NTI7
sequenceLength 404
species [Species:48887] Homo sapiens
stId uniprot:P51810
url http://purl.uniprot.org/uniprot/P51810
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