UniProt:P51809 VAMP7

chain
  • initiator methionine:1
  • chain:2-220
checksum 9C1AA5C590375CEF
comment
  • FUNCTION Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.SUBUNIT Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. May interact with STX17 (By similarity). Interacts with PICALM (PubMed:23741335). Interacts with RAB21 (PubMed:25648148).INTERACTION In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).ALTERNATIVE PRODUCTS Detected in all tissues tested.MISCELLANEOUS The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.MISCELLANEOUS Loss-of-function mutant (antisense inhibition) displays impaired granzyme B release and target cell killing by natural killer cells.SIMILARITY Belongs to the synaptobrevin family.SEQUENCE CAUTION Sequence of unknown origin in the C-terminal part.
crossReference
databaseName UniProt
dbId 65392
description
  • recommendedName: Vesicle-associated membrane protein 7 shortName: VAMP-7 alternativeName: Synaptobrevin-like protein 1 alternativeName: Tetanus-insensitive VAMP shortName: Ti-VAMP
displayName UniProt:P51809 VAMP7
geneName
  • VAMP7
  • SYBL1
identifier P51809
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Coiled coil
  • Cytoplasmic vesicle
  • Direct protein sequencing
  • Endoplasmic reticulum
  • Endosome
  • Exocytosis
  • Golgi apparatus
  • Lysosome
  • Membrane
  • Phosphoprotein
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Signal-anchor
  • Synapse
  • Synaptosome
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • VAMP7
otherIdentifier
  • 11757799_s_at
  • 17108605
  • 17116684
  • 202829_PM_s_at
  • 202829_s_at
  • 34753_at
  • 3996946
  • 3996947
  • 3996948
  • 3996949
  • 3996950
  • 3996951
  • 3996952
  • 3996960
  • 3996961
  • 3996962
  • 3996963
  • 3996964
  • 4032756
  • 4032757
  • 4032758
  • 4032759
  • 4032760
  • 4032761
  • 4032762
  • 4032770
  • 4032771
  • 4032772
  • 4032773
  • 4032774
  • 6845
  • 8171041
  • 8176962
  • A_23_P22671
  • GE60150
  • GO:0000149
  • GO:0002376
  • GO:0005484
  • GO:0005515
  • GO:0005737
  • GO:0005764
  • GO:0005765
  • GO:0005768
  • GO:0005783
  • GO:0005789
  • GO:0005794
  • GO:0005802
  • GO:0005886
  • GO:0006887
  • GO:0006888
  • GO:0006906
  • GO:0006911
  • GO:0008333
  • GO:0012505
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0017156
  • GO:0030027
  • GO:0030141
  • GO:0030658
  • GO:0030667
  • GO:0030669
  • GO:0030670
  • GO:0031091
  • GO:0031143
  • GO:0031201
  • GO:0031410
  • GO:0031902
  • GO:0035577
  • GO:0043005
  • GO:0043308
  • GO:0043312
  • GO:0043320
  • GO:0045202
  • GO:0045335
  • GO:0060090
  • GO:0061024
  • GO:0070062
  • GO:0120025
  • GO:1903595
  • HMNXSV003026048
  • ILMN_1690524
  • PH_hs_0002133
  • TC0X000792.hg
  • TC0X001948.hg
  • TC0Y000109.hg
  • X92396_at
  • g5032136_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • VAMP7_HUMAN
  • Q53GY7
  • Q7Z409
  • Q9H4A7
sequenceLength 220
species [Species:48887] Homo sapiens
stId uniprot:P51809
url http://purl.uniprot.org/uniprot/P51809
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