UniProt:P51648-2 ALDH3A2

chain
  • chain:1-485
checksum 209601CB5803C7E3
comment
  • FUNCTION Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:18035827, PubMed:18182499, PubMed:22633490, PubMed:25047030, PubMed:9133646, PubMed:9662422). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490).CATALYTIC ACTIVITY an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)CATALYTIC ACTIVITY a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)CATALYTIC ACTIVITY (2E)-hexadecenal + NAD(+) + H2O = (E)-hexadec-2-enoate + NADH + 2 H(+)CATALYTIC ACTIVITY hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2OCATALYTIC ACTIVITY 22-oxodocosanoate + NAD(+) + H2O = docosanedioate + NADH + 2 H(+)CATALYTIC ACTIVITY 2,6,10,14-tetramethylpentadecanal + NAD(+) + H2O = 2,6,10,14-tetramethylpentadecanoate + NADH + 2 H(+)CATALYTIC ACTIVITY octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)CATALYTIC ACTIVITY dodecanoate + NADH + 2 H(+) = dodecanal + NAD(+) + H2OCATALYTIC ACTIVITY decanal + NAD(+) + H2O = decanoate + NADH + 2 H(+)CATALYTIC ACTIVITY tetradecanal + NAD(+) + H2O = tetradecanoate + NADH + 2 H(+)CATALYTIC ACTIVITY octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+)CATALYTIC ACTIVITY heptanal + NAD(+) + H2O = heptanoate + NADH + 2 H(+)CATALYTIC ACTIVITY (2E,6E)-farnesal + NAD(+) + H2O = (2E,6E)-farnesoate + NADH + 2 H(+)BIOPHYSICOCHEMICAL PROPERTIES kcat is 2.18 sec(-1) for decanal as substrate. kcat is 2.23 sec(-1) for dodecanal as substrate. kcat is 0.86 sec(-1) for tetradecanal as substrate. kcat is 0.95 sec(-1) for hexadecanal as substrate. kcat is 1.52 sec(-1) for octadecanal as substrate. kcat is 0.93 sec(-1) for farnesal as substrate. kcat is 1.28 sec(-1) for NAD as substrate.SUBUNIT Homodimer.SUBCELLULAR LOCATION Detected in liver (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the aldehyde dehydrogenase family.
crossReference
databaseName UniProt
dbId 146324
description
  • recommendedName: Aldehyde dehydrogenase family 3 member A2 ecNumber evidence="7 8 9 10 12 14"1.2.1.3 ecNumber evidence="7"1.2.1.94 alternativeName: fullName evidence="18"Aldehyde dehydrogenase 10 alternativeName: Fatty aldehyde dehydrogenase alternativeName: Microsomal aldehyde dehydrogenase
displayName UniProt:P51648-2 ALDH3A2
geneName
  • ALDH3A2
  • ALDH10
  • FALDH
identifier P51648
isSequenceChanged false
isoformParent
keyword
  • 3D-structure
  • Alternative splicing
  • Direct protein sequencing
  • Disease variant
  • Endoplasmic reticulum
  • Fatty acid metabolism
  • Ichthyosis
  • Intellectual disability
  • Lipid metabolism
  • Membrane
  • Microsome
  • NAD
  • Oxidoreductase
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • ALDH3A2
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceIsoform
secondaryIdentifier
  • AL3A2_HUMAN
  • Q6I9T3
  • Q93011
  • Q96J37
sequenceLength 485
species [Species:48887] Homo sapiens
stId uniprot:P51648-2
url http://purl.uniprot.org/uniprot/P51648-2
variantIdentifier P51648-2
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