Reactome | UniProt:P51648-1 ALDH3A2

Schema > ReferenceIsoform > Entries

UniProt:P51648-1 ALDH3A2 Show undefined attributes

chain	chain:1-485
checksum	209601CB5803C7E3
comment	FUNCTION Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:18035827, PubMed:18182499, PubMed:22633490, PubMed:25047030, PubMed:9133646, PubMed:9662422). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490).CATALYTIC ACTIVITY an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)CATALYTIC ACTIVITY a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)CATALYTIC ACTIVITY (2E)-hexadecenal + NAD(+) + H2O = (E)-hexadec-2-enoate + NADH + 2 H(+)CATALYTIC ACTIVITY hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2OCATALYTIC ACTIVITY 22-oxodocosanoate + NAD(+) + H2O = docosanedioate + NADH + 2 H(+)CATALYTIC ACTIVITY 2,6,10,14-tetramethylpentadecanal + NAD(+) + H2O = 2,6,10,14-tetramethylpentadecanoate + NADH + 2 H(+)CATALYTIC ACTIVITY octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)CATALYTIC ACTIVITY dodecanoate + NADH + 2 H(+) = dodecanal + NAD(+) + H2OCATALYTIC ACTIVITY decanal + NAD(+) + H2O = decanoate + NADH + 2 H(+)CATALYTIC ACTIVITY tetradecanal + NAD(+) + H2O = tetradecanoate + NADH + 2 H(+)CATALYTIC ACTIVITY octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+)CATALYTIC ACTIVITY heptanal + NAD(+) + H2O = heptanoate + NADH + 2 H(+)CATALYTIC ACTIVITY (2E,6E)-farnesal + NAD(+) + H2O = (2E,6E)-farnesoate + NADH + 2 H(+)BIOPHYSICOCHEMICAL PROPERTIES kcat is 2.18 sec(-1) for decanal as substrate. kcat is 2.23 sec(-1) for dodecanal as substrate. kcat is 0.86 sec(-1) for tetradecanal as substrate. kcat is 0.95 sec(-1) for hexadecanal as substrate. kcat is 1.52 sec(-1) for octadecanal as substrate. kcat is 0.93 sec(-1) for farnesal as substrate. kcat is 1.28 sec(-1) for NAD as substrate.SUBUNIT Homodimer.SUBCELLULAR LOCATION Detected in liver (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the aldehyde dehydrogenase family.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:12412805] RefSeq:NP_001356067.1 [DatabaseIdentifier:12412801] RefSeq:NP_001356066.1 [DatabaseIdentifier:12412803] RefSeq:NP_001356068.1 [DatabaseIdentifier:12412800] RefSeq:NP_000373.1 [DatabaseIdentifier:12412802] RefSeq:NP_001356065.1 [DatabaseIdentifier:12412804] RefSeq:NP_001026976.1 [DatabaseIdentifier:12285170] Pharos - Targets:P51648 [DatabaseIdentifier:12244753] PRO:P51648 [DatabaseIdentifier:12174942] PDB:4QGK [DatabaseIdentifier:12136190] Orphanet:ALDH3A2 [DatabaseIdentifier:12124861] OpenTargets:ENSG00000072210 [DatabaseIdentifier:11850967] IntEnz:1.2.1.94 [DatabaseIdentifier:11840326] HPA:ENSG00000072210-ALDH3A2 [DatabaseIdentifier:11831275] HMDB Protein:HMDBP00296 [DatabaseIdentifier:11787252] GeneCards:ALDH3A2 [DatabaseIdentifier:11722044] ENSEMBL:ENST00000581518 [DatabaseIdentifier:11722043] ENSEMBL:ENST00000579855 [DatabaseIdentifier:11722040] ENSEMBL:ENST00000176643 [DatabaseIdentifier:11722041] ENSEMBL:ENST00000672357 [DatabaseIdentifier:11722042] ENSEMBL:ENST00000339618 [DatabaseIdentifier:11599343] ENSEMBL:ENSP00000345774 [DatabaseIdentifier:11599344] ENSEMBL:ENSP00000176643 [DatabaseIdentifier:11599342] ENSEMBL:ENSP00000461916 [DatabaseIdentifier:11599341] ENSEMBL:ENSP00000463637 [DatabaseIdentifier:11599345] ENSEMBL:ENSP00000500092 [DatabaseIdentifier:11492245] ENSEMBL:ENSG00000072210
databaseName	UniProt
dbId	404290
description	recommendedName: Aldehyde dehydrogenase family 3 member A2 ecNumber evidence="7 8 9 10 12 14"1.2.1.3 ecNumber evidence="7"1.2.1.94 alternativeName: fullName evidence="18"Aldehyde dehydrogenase 10 alternativeName: Fatty aldehyde dehydrogenase alternativeName: Microsomal aldehyde dehydrogenase
displayName	UniProt:P51648-1 ALDH3A2
geneName	ALDH3A2 ALDH10 FALDH
identifier	P51648
isSequenceChanged	false
isoformParent	[ReferenceGeneProduct:uniprot:P51648] UniProt:P51648 ALDH3A2
keyword	3D-structure Alternative splicing Direct protein sequencing Disease variant Endoplasmic reticulum Fatty acid metabolism Ichthyosis Intellectual disability Lipid metabolism Membrane Microsome NAD Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	ALDH3A2
otherIdentifier	11720503_a_at 11739097_x_at 11756679_a_at 16832147 16832166 202053_PM_s_at 202053_s_at 202054_PM_s_at 202054_s_at 210544_PM_s_at 210544_s_at 224 3714069 3714070 3714071 3714072 3714073 3714074 3714075 3714076 3714077 3714078 3714079 3714080 3714081 3714082 3714083 3714084 3714085 3714086 3714087 3714088 3714089 3714090 3714091 3714092 3714095 3714096 3714097 3714098 3714099 3714100 3714101 3714102 3714103 3714104 40409_at 8005638 8005655 A_14_P122363 A_14_P124701 A_14_P126979 A_23_P129896 A_33_P3336617 A_33_P3336622 GE61075 GE84056 GO:0004028 GO:0004029 GO:0005515 GO:0005737 GO:0005777 GO:0005778 GO:0005783 GO:0005789 GO:0005829 GO:0006081 GO:0006629 GO:0006631 GO:0006714 GO:0007417 GO:0007422 GO:0008544 GO:0016020 GO:0016491 GO:0016620 GO:0033306 GO:0042803 GO:0043226 GO:0043231 GO:0046458 GO:0046577 GO:0048856 GO:0050061 GO:0052814 GO:0102673 HMNXSV003051186 ILMN_1667564 ILMN_1794825 ILMN_2401641 PH_hs_0025801 TC17000246.hg TC17000247.hg U46689_at g1082035_3p_a_at g12803234_3p_a_at g4557302_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9609891] ALDH3A2-1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6811616] ALDH3A2-1 [endoplasmic reticulum membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12698364] UCSC:P51648 ALDH3A2 [ReferenceDNASequence:12110226] OMIM:609523 ALDH3A2 [ReferenceDNASequence:12071646] NCBI Gene:224 ALDH3A2 [ReferenceDNASequence:11987553] Monarch:224 ALDH3A2 [ReferenceDNASequence:11897086] KEGG:hsa:224 ALDH3A2 [ReferenceDNASequence:11818890] HGNC:403 ALDH3A2 [ReferenceDNASequence:11430171] dbSNP Gene:224 ALDH3A2 [ReferenceDNASequence:11412861] CTD Gene:224 ALDH3A2 [ReferenceDNASequence:11394127] COSMIC - genes:ALDH3A2 ALDH3A2 [ReferenceDNASequence:11357764] BioGPS Gene:224 ALDH3A2 [ReferenceDNASequence:ensembl:ENSG00000072210] ENSEMBL:ENSG00000072210 ALDH3A2
referenceTranscript	[ReferenceRNASequence:12594492] RefSeq:NM_001031806.2 ALDH3A2 [ReferenceRNASequence:12594487] RefSeq:NM_001369136.1 ALDH3A2 [ReferenceRNASequence:12594488] RefSeq:NM_001369138.2 ALDH3A2 [ReferenceRNASequence:12594490] RefSeq:NM_001369137.2 ALDH3A2 [ReferenceRNASequence:12594489] RefSeq:NM_001369139.1 ALDH3A2 [ReferenceRNASequence:12594491] RefSeq:NM_000382.3 ALDH3A2
schemaClass	ReferenceIsoform
secondaryIdentifier	AL3A2_HUMAN Q6I9T3 Q93011 Q96J37
sequenceLength	485
species	[Species:48887] Homo sapiens
stId	uniprot:P51648-1
url	http://purl.uniprot.org/uniprot/P51648-1
variantIdentifier	P51648-1

Referrals

(referenceEntity)