UniProt:P51178 PLCD1

chain
  • chain:1-756
checksum 6C6FD7F89BA08C83
comment
  • FUNCTION The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:9188725). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PubMed:7890667, PubMed:9188725).CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)COFACTOR Binds 5 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.SUBUNIT Interacts with TGM2.INTERACTION Strongly expressed in lung, liver and heart. Also expressed at least in pancreas, kidney, skeletal muscle, placenta and brain.DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference
databaseName UniProt
dbId 61706
description
  • recommendedName: fullName evidence="13"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 ecNumber evidence="10 11"3.1.4.11 alternativeName: Phosphoinositide phospholipase C-delta-1 alternativeName: Phospholipase C-III shortName: PLC-III alternativeName: Phospholipase C-delta-1 shortName: PLC-delta-1
displayName UniProt:P51178 PLCD1
geneName
  • PLCD1
identifier P51178
isSequenceChanged false
keyword
  • Alternative splicing
  • Calcium
  • Disease variant
  • Glycoprotein
  • Hydrolase
  • Lipid degradation
  • Lipid metabolism
  • Metal-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transducer
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • PLCD1
otherIdentifier
  • 11718816_a_at
  • 16952218
  • 205125_PM_at
  • 205125_at
  • 2669489
  • 2669490
  • 2669491
  • 2669492
  • 2669493
  • 2669494
  • 2669495
  • 2669496
  • 2669497
  • 2669498
  • 2669499
  • 2669500
  • 2669501
  • 2669502
  • 2669503
  • 2669504
  • 2669505
  • 2669506
  • 2669507
  • 2669508
  • 2669509
  • 2669510
  • 2669511
  • 2669512
  • 2669516
  • 2669517
  • 2669519
  • 2669520
  • 2669521
  • 2669522
  • 2669523
  • 2669524
  • 2669526
  • 2669527
  • 2669528
  • 37596_at
  • 5333
  • 8086185
  • A_23_P80739
  • GE58900
  • GO:0004435
  • GO:0004629
  • GO:0005509
  • GO:0005515
  • GO:0005546
  • GO:0005737
  • GO:0005886
  • GO:0006629
  • GO:0006644
  • GO:0007165
  • GO:0008081
  • GO:0016042
  • GO:0016787
  • GO:0032794
  • GO:0035556
  • GO:0043168
  • GO:0046488
  • GO:0046872
  • GO:0070062
  • GO:0120548
  • GO:0141212
  • GO:1901981
  • HMNXSV003034892
  • ILMN_1769394
  • PH_hs_0027710
  • TC03001292.hg
  • TC03002861.hg
  • U09117_at
  • g5453909_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PLCD1_HUMAN
  • B3KR14
  • Q86VN8
sequenceLength 756
species [Species:48887] Homo sapiens
stId uniprot:P51178
url http://purl.uniprot.org/uniprot/P51178
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