UniProt:P51151 RAB9A

chain
  • initiator methionine:1
  • chain:2-201
checksum 65B502C21E97DB72
comment
  • FUNCTION The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN) (PubMed:34793709). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (PubMed:34793709). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)COFACTOR Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs).SUBUNIT Interacts (preferentially in its GTP-bound form) with GCC2 (via its GRIP domain) (PubMed:16885419, PubMed:18243103). Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:22637480). Interacts with SGSM2 (PubMed:21808068). The GTP-bound form but not the GDP-bound form interacts with HPS4 and BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (PubMed:20048159). Interacts (GTP-bound form) with NDE1; two RAB9A-GTP molecules lie on the opposite sides of the NDE1 homodimer; the interaction leads to RAB9A-dynein motor tethering (PubMed:34793709). Interacts (GTP-bound form) with NDEL1 (PubMed:34793709).INTERACTION Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). Mainly localizes to late endosomes and partially localizes to Golgi (PubMed:34793709). Colocalizes with NDE1 to membrane vesicles (PubMed:34793709).DOMAIN Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.SIMILARITY Belongs to the small GTPase superfamily. Rab family.
crossReference
databaseName UniProt
dbId 62828
description
  • recommendedName: Ras-related protein Rab-9A ecNumber evidence="3"3.6.5.2
displayName UniProt:P51151 RAB9A
geneName
  • RAB9A
  • RAB9
identifier P51151
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cell membrane
  • Cytoplasmic vesicle
  • Endoplasmic reticulum
  • Endosome
  • Golgi apparatus
  • GTP-binding
  • Hydrolase
  • Lipoprotein
  • Membrane
  • Nucleotide-binding
  • Phosphoprotein
  • Prenylation
  • Protein transport
  • Proteomics identification
  • Reference proteome
  • Transport
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • RAB9A
otherIdentifier
  • 11742737_a_at
  • 17101616
  • 221808_PM_at
  • 221808_at
  • 39628_at
  • 3969423
  • 3969424
  • 3969425
  • 3969426
  • 3969434
  • 3969435
  • 3969436
  • 3969437
  • 3969438
  • 3969439
  • 3969440
  • 3969441
  • 3969442
  • 3969444
  • 50329_s_at
  • 50332_r_at
  • 79341_at
  • 8166098
  • 9367
  • A_14_P109668
  • A_23_P45389
  • GE59173
  • GO:0000139
  • GO:0000166
  • GO:0003924
  • GO:0003925
  • GO:0005515
  • GO:0005525
  • GO:0005764
  • GO:0005768
  • GO:0005770
  • GO:0005783
  • GO:0005789
  • GO:0005794
  • GO:0005829
  • GO:0005886
  • GO:0006898
  • GO:0015031
  • GO:0016020
  • GO:0016192
  • GO:0016787
  • GO:0019003
  • GO:0030133
  • GO:0030659
  • GO:0030670
  • GO:0031090
  • GO:0031410
  • GO:0032482
  • GO:0032588
  • GO:0032880
  • GO:0042147
  • GO:0042470
  • GO:0042802
  • GO:0045335
  • GO:0045921
  • GO:0070062
  • GO:0098772
  • HMNXSV003035745
  • Hs.28726.0.S1_3p_at
  • ILMN_1750409
  • PH_hs_0025957
  • TC0X000060.hg
  • U44103_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RAB9A_HUMAN
  • A8K390
  • Q6ICN1
sequenceLength 201
species [Species:48887] Homo sapiens
stId uniprot:P51151
url http://purl.uniprot.org/uniprot/P51151
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