UniProt:P50135 HNMT

chain
  • chain:1-292
checksum 9CCADD1EE0CCB653
comment
  • FUNCTION Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.CATALYTIC ACTIVITY histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)BIOPHYSICOCHEMICAL PROPERTIES Monomer.SUBCELLULAR LOCATION Variant Ile-105 has a reduced activity and seems to be linked with a predisposition to asthma.DISEASE The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry.MISCELLANEOUS Has no histamine-methylating activity.SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.
crossReference
databaseName UniProt
dbId 56604
description
  • recommendedName: Histamine N-methyltransferase shortName: HMT ecNumber evidence="4"2.1.1.8
displayName UniProt:P50135 HNMT
geneName
  • HNMT
identifier P50135
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cytoplasm
  • Disease variant
  • Intellectual disability
  • Methyltransferase
  • Proteomics identification
  • Reference proteome
  • S-adenosyl-L-methionine
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • HNMT
otherIdentifier
  • 11725054_a_at
  • 11725055_at
  • 11733616_at
  • 11738327_a_at
  • 11738328_at
  • 11762302_at
  • 11762303_x_at
  • 1554303_PM_at
  • 1554303_at
  • 16886105
  • 204111_PM_at
  • 204111_at
  • 204112_PM_s_at
  • 204112_s_at
  • 211732_3p_x_at
  • 211732_PM_x_at
  • 211732_x_at
  • 228772_PM_at
  • 228772_at
  • 2507900
  • 2507901
  • 2507902
  • 2507903
  • 2507905
  • 2507906
  • 2507907
  • 2507908
  • 2507910
  • 2507911
  • 2507913
  • 2507914
  • 2507915
  • 2507920
  • 2507921
  • 2507922
  • 2507924
  • 2507925
  • 2507926
  • 2507927
  • 2507929
  • 2507930
  • 2507932
  • 3176
  • 37604_at
  • 64658_at
  • 8045499
  • A_14_P118665
  • A_14_P136951
  • A_14_P200729
  • A_23_P56734
  • A_24_P915806
  • A_33_P3347281
  • GE60536
  • GO:0001692
  • GO:0001695
  • GO:0005654
  • GO:0005737
  • GO:0005813
  • GO:0005815
  • GO:0005829
  • GO:0006520
  • GO:0006548
  • GO:0007268
  • GO:0007585
  • GO:0008168
  • GO:0008170
  • GO:0016740
  • GO:0032259
  • GO:0046539
  • GO:0070062
  • HMNXSV003001500
  • HMNXSV003026157
  • Hs.42151.0.A1_3p_at
  • Hs.81182.0.S2_3p_at
  • Hs2.385725.1.S1_3p_at
  • ILMN_1705984
  • ILMN_1713685
  • ILMN_1751789
  • ILMN_1790881
  • ILMN_2284744
  • PH_hs_0022113
  • U44111_at
  • g13543496_3p_s_at
  • g5901969_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • HNMT_HUMAN
  • B2R9J3
  • Q546Z6
  • Q7Z7I2
  • Q8IU56
  • Q8WW98
  • Q9BRW6
sequenceLength 292
species [Species:48887] Homo sapiens
stId uniprot:P50135
url http://purl.uniprot.org/uniprot/P50135
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