UniProt:P48448 ALDH3B2

chain
  • chain:1-382
  • propeptide:383-385
checksum 418879E834C3F9C6
comment
  • FUNCTION Oxidizes medium and long chain fatty aldehydes in lipid droplets into non-toxic fatty acids.CATALYTIC ACTIVITY an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)CATALYTIC ACTIVITY a long-chain fatty aldehyde + NAD(+) + H2O = a long-chain fatty acid + NADH + 2 H(+)CATALYTIC ACTIVITY a medium-chain fatty aldehyde + NAD(+) + H2O = a medium-chain fatty acid + NADH + 2 H(+)CATALYTIC ACTIVITY hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2OCATALYTIC ACTIVITY octanal + NAD(+) + H2O = octanoate + NADH + 2 H(+)PATHWAY Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.INTERACTION Salivary gland (PubMed:8890755). Expressed at protein level in placenta (PubMed:31847104).PTM Geranylgeranylation is important for localization to lipid droplets and enzyme activity.SIMILARITY Belongs to the aldehyde dehydrogenase family.
crossReference
databaseName UniProt
dbId 53594
description
  • recommendedName: Aldehyde dehydrogenase family 3 member B2 shortName: ALDH3B2 ecNumber evidence="2"1.2.1.3 alternativeName: Aldehyde dehydrogenase 8 alternativeName: Long-chain fatty aldehyde dehydrogenase ecNumber evidence="2"1.2.1.48
displayName UniProt:P48448 ALDH3B2
geneName
  • ALDH3B2
  • ALDH8
identifier P48448
isSequenceChanged false
keyword
  • Lipid droplet
  • Lipid metabolism
  • Lipoprotein
  • Methylation
  • NAD
  • Oxidoreductase
  • Prenylation
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • ALDH3B2
otherIdentifier
  • 11727500_at
  • 11727501_a_at
  • 11727502_x_at
  • 11751542_a_at
  • 16741142
  • 204941_PM_s_at
  • 204941_s_at
  • 204942_PM_s_at
  • 204942_s_at
  • 222
  • 3337344
  • 3337345
  • 3337350
  • 3379092
  • 3379093
  • 3379094
  • 3379095
  • 3379096
  • 3379097
  • 3379098
  • 3379099
  • 3379100
  • 3379101
  • 3379102
  • 3379103
  • 3379104
  • 3379105
  • 3379106
  • 3379107
  • 3379108
  • 3379109
  • 3379111
  • 3379114
  • 3379116
  • 3379117
  • 3379118
  • 3379119
  • 3379120
  • 37956_at
  • 7949882
  • A_23_P24311
  • GE80937
  • GO:0004028
  • GO:0004029
  • GO:0004030
  • GO:0005515
  • GO:0005737
  • GO:0005811
  • GO:0006066
  • GO:0006068
  • GO:0006081
  • GO:0006629
  • GO:0016020
  • GO:0016491
  • GO:0016620
  • GO:0030149
  • GO:0043226
  • GO:0050061
  • GO:0052814
  • HMNXSV003027745
  • Hs.87539.0.S1_3p_s_at
  • ILMN_1761514
  • ILMN_1763666
  • ILMN_2363880
  • PH_hs_0004918
  • TC11001995.hg
  • U37519_at
  • g4580414_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AL3B2_HUMAN
  • Q53Y98
  • Q8NAL5
  • Q96IB2
sequenceLength 385
species [Species:48887] Homo sapiens
stId uniprot:P48448
url http://purl.uniprot.org/uniprot/P48448
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