UniProt:P48023 FASLG

chain
  • chain:1-281
  • chain:1-129
  • chain:1-81
  • chain:130-281
checksum A8A6EB358246E9BB
comment
  • FUNCTION Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:7528780, PubMed:9228058, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260).FUNCTION Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process (PubMed:27806260).FUNCTION Cytoplasmic form induces gene transcription inhibition.SUBUNIT Homotrimer (PubMed:27806260). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.INTERACTION Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115).SUBCELLULAR LOCATION May be released into the extracellular fluid by cleavage from the cell surface.SUBCELLULAR LOCATION The FasL ICD cytoplasmic form is translocated into the nucleus.ALTERNATIVE PRODUCTS The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.PTM N-glycosylated (PubMed:9228058). Glycosylation enhances apoptotic activity (PubMed:27806260).PTM Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.PTM Monoubiquitinated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the tumor necrosis factor family.ONLINE INFORMATION FASLG mutation dbONLINE INFORMATION FAS-ligand entry
crossReference
databaseName UniProt
dbId 66213
description
  • recommendedName: Tumor necrosis factor ligand superfamily member 6 alternativeName: Apoptosis antigen ligand shortName: APTL alternativeName: CD95 ligand shortName: CD95-L alternativeName: Fas antigen ligand shortName: Fas ligand shortName: FasL cdAntigenNameCD178/cdAntigenName component recommendedName: Tumor necrosis factor ligand superfamily member 6, membrane form /component component recommendedName: Tumor necrosis factor ligand superfamily member 6, soluble form alternativeName: Receptor-binding FasL ectodomain alternativeName: Soluble Fas ligand shortName: sFasL /component component recommendedName: ADAM10-processed FasL form shortName: APL /component component recommendedName: FasL intracellular domain shortName: FasL ICD alternativeName: SPPL2A-processed FasL form shortName: SPA /component
displayName UniProt:P48023 FASLG
geneName
  • FASLG
  • APT1LG1
  • CD95L
  • FASL
  • TNFSF6
identifier P48023
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Apoptosis
  • Cell membrane
  • Cytokine
  • Cytoplasmic vesicle
  • Disulfide bond
  • Glycoprotein
  • Lysosome
  • Membrane
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Repressor
  • Secreted
  • Signal-anchor
  • Transcription
  • Transcription regulation
  • Transmembrane
  • Transmembrane helix
  • Ubl conjugation
modified [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType Protein
name
  • FASLG
otherIdentifier
  • 11732555_at
  • 11732556_a_at
  • 16673928
  • 1851_s_at
  • 1858_at
  • 210865_PM_at
  • 210865_at
  • 211333_PM_s_at
  • 211333_s_at
  • 2367606
  • 2367607
  • 2367608
  • 2367609
  • 2367610
  • 2367611
  • 2367616
  • 2367617
  • 356
  • 7907430
  • A_14_P105867
  • A_23_P369815
  • A_24_P54220
  • D38122_at
  • GE784965
  • GO:0000122
  • GO:0002376
  • GO:0005102
  • GO:0005123
  • GO:0005125
  • GO:0005164
  • GO:0005515
  • GO:0005576
  • GO:0005615
  • GO:0005634
  • GO:0005737
  • GO:0005764
  • GO:0005886
  • GO:0005901
  • GO:0006355
  • GO:0006915
  • GO:0006925
  • GO:0006955
  • GO:0007165
  • GO:0007267
  • GO:0008284
  • GO:0008625
  • GO:0009897
  • GO:0009986
  • GO:0012501
  • GO:0016020
  • GO:0016525
  • GO:0030644
  • GO:0031410
  • GO:0032496
  • GO:0043065
  • GO:0043123
  • GO:0043202
  • GO:0043525
  • GO:0045742
  • GO:0046666
  • GO:0048018
  • GO:0048388
  • GO:0048471
  • GO:0055085
  • GO:0060205
  • GO:0061024
  • GO:0070062
  • GO:0070231
  • GO:0070266
  • GO:0070848
  • GO:0071346
  • GO:0097190
  • GO:0097191
  • GO:0097527
  • GO:0098772
  • GO:1903514
  • GO:1905782
  • GO:2000353
  • GO:2001238
  • HMNXSV003052998
  • ILMN_1781824
  • PH_hs_0000267
  • TC01001506.hg
  • U11821_s_at
  • g12597288_3p_a_at
  • g601892_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TNFL6_HUMAN
  • Q9BZP9
sequenceLength 281
species [Species:48887] Homo sapiens
stId uniprot:P48023
url http://purl.uniprot.org/uniprot/P48023

Referrals

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