Reactome | UniProt:P47871 GCGR

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UniProt:P47871 GCGR Show undefined attributes

chain	signal peptide:1-25 chain:26-477
checksum	ADBB477C6267AE6E
comment	FUNCTION G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:32193322, PubMed:38346960). Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.SUBUNIT Interacts with glucagon (PubMed:32193322). Interacts with GNAS (PubMed:32193322, PubMed:38346960). Interacts with GNAI1 (PubMed:32193322, PubMed:38346960).SUBCELLULAR LOCATION Is rapidly internalized after ligand-binding.PTM Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Selective recognition of glucagon over glucagon-like peptide is determined by residues located at the N-terminal end of the glucagon peptide.SIMILARITY Belongs to the G-protein coupled receptor 2 family.
crossReference	[DatabaseIdentifier:12381889] RefSeq:NP_000151.1 [DatabaseIdentifier:12817034] ZINC target:P47871 [DatabaseIdentifier:12813617] ZINC - Substances:GLR_HUMAN [DatabaseIdentifier:12809762] ZINC - Predictions - Purchasable:GLR_HUMAN [DatabaseIdentifier:12806422] ZINC - Investigational:GLR_HUMAN [DatabaseIdentifier:12381890] RefSeq:XP_006722340.1 [DatabaseIdentifier:12381891] RefSeq:XP_054188639.1 [DatabaseIdentifier:11478621] ENSEMBL:ENSG00000288269 [DatabaseIdentifier:11478620] ENSEMBL:ENSG00000215644 [DatabaseIdentifier:11578658] ENSEMBL:ENSP00000500297 [DatabaseIdentifier:11578659] ENSEMBL:ENSP00000383558 [DatabaseIdentifier:11701357] ENSEMBL:ENST00000671794 [DatabaseIdentifier:11701358] ENSEMBL:ENST00000400723 [DatabaseIdentifier:11780198] Guide to Pharmacology - Targets:251 [DatabaseIdentifier:11791735] GeneCards:GCGR [DatabaseIdentifier:11807733] GlyGen:P47871 [DatabaseIdentifier:11833472] HMDB Protein:HMDBP07710 [DatabaseIdentifier:11844735] HPA:ENSG00000215644-GCGR [DatabaseIdentifier:12129366] OpenTargets:ENSG00000215644 [DatabaseIdentifier:12137514] Orphanet:GCGR [DatabaseIdentifier:12164639] PDB:8JIT [DatabaseIdentifier:12164637] PDB:8JIU [DatabaseIdentifier:12209699] PDB:5XEZ [DatabaseIdentifier:12164388] PDB:8WG8 [DatabaseIdentifier:12164495] PDB:8YW5 [DatabaseIdentifier:12164423] PDB:6WPW [DatabaseIdentifier:12168411] PDB:8JRV [DatabaseIdentifier:12209703] PDB:4LF3 [DatabaseIdentifier:12209701] PDB:4L6R [DatabaseIdentifier:12179896] PDB:2A83 [DatabaseIdentifier:12140270] PDB:8JRU [DatabaseIdentifier:12164563] PDB:8FU6 [DatabaseIdentifier:12164634] PDB:8JIQ [DatabaseIdentifier:12209702] PDB:5EE7 [DatabaseIdentifier:12179880] PDB:3CZF [DatabaseIdentifier:12164600] PDB:6LMK [DatabaseIdentifier:12165015] PDB:6LML [DatabaseIdentifier:12164521] PDB:7V35 [DatabaseIdentifier:12209700] PDB:4ERS [DatabaseIdentifier:12164630] PDB:6WHC [DatabaseIdentifier:12271596] PRO:P47871 [DatabaseIdentifier:12289578] Pharos - Targets:P47871 [DatabaseIdentifier:12381892] RefSeq:XP_054171686.1
databaseName	UniProt
dbId	55732
description	recommendedName: Glucagon receptor shortName: GL-R
displayName	UniProt:P47871 GCGR
geneName	GCGR
identifier	P47871
isSequenceChanged	false
keyword	3D-structure Cell membrane Diabetes mellitus Disease variant Disulfide bond G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	GCGR
otherIdentifier	11756776_a_at 16838901 210565_PM_at 210565_at 2642 32886_at 4040455 4040456 4040457 4040458 4040459 4040460 4040461 4040462 4040463 4040464 4040465 4040466 4040467 4040468 4040469 4040470 4040471 4040472 4040473 4040474 4040475 4040476 4040477 4040478 4040479 4040480 4040481 4040482 8019669 A_14_P112038 A_23_P15751 A_33_P3409467 GE62703 GO:0004888 GO:0004930 GO:0004967 GO:0005085 GO:0005886 GO:0006091 GO:0007165 GO:0007166 GO:0007186 GO:0007188 GO:0007189 GO:0007584 GO:0008217 GO:0009267 GO:0010628 GO:0016020 GO:0017046 GO:0038023 GO:0042593 GO:0042594 GO:0070873 GO:0071377 HMNXSV003002082 ILMN_1725311 L20316_at PH_hs_0027517 TC17000937.hg g439689_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-9820623] GCGR [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000215644] ENSEMBL:ENSG00000215644 GCGR [ReferenceDNASequence:12741649] UCSC:P47871 GCGR [ReferenceDNASequence:11344199] BioGPS Gene:2642 GCGR [ReferenceDNASequence:11400005] COSMIC - genes:GCGR GCGR [ReferenceDNASequence:11419593] CTD Gene:2642 GCGR [ReferenceDNASequence:11437085] dbSNP Gene:2642 GCGR [ReferenceDNASequence:11823408] HGNC:4192 GCGR [ReferenceDNASequence:11884620] KEGG:hsa:2642 GCGR [ReferenceDNASequence:11973988] Monarch:2642 GCGR [ReferenceDNASequence:12058081] NCBI Gene:2642 GCGR [ReferenceDNASequence:12114031] OMIM:138033 GCGR
referenceTranscript	[ReferenceRNASequence:12563678] RefSeq:XM_054315711.1 GCGR [ReferenceRNASequence:12563679] RefSeq:XM_006722277.2 GCGR [ReferenceRNASequence:12563680] RefSeq:XM_054332664.1 GCGR [ReferenceRNASequence:12563677] RefSeq:NM_000160.5 GCGR
schemaClass	ReferenceGeneProduct
secondaryIdentifier	GLR_HUMAN Q2M3M5
sequenceLength	477
species	[Species:48887] Homo sapiens
stId	uniprot:P47871
url	http://purl.uniprot.org/uniprot/P47871

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(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-9820623] GCGR [plasma membrane]