UniProt:P47756 CAPZB

chain
  • initiator methionine:1
  • chain:2-272
checksum E6466A68B1254FD0
comment
  • FUNCTION F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).SUBUNIT Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit. Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin (By similarity). Interacts with ARHGAP17 (PubMed:16678097). Interaction with RCSD1/CAPZIP (PubMed:15850461). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5 (PubMed:19922875). Interacts with ACTG1 (PubMed:28493397). Directly interacts with CRACD; this interaction decreases binding to actin (PubMed:30361697).INTERACTION Belongs to the F-actin-capping protein beta subunit family.
crossReference
databaseName UniProt
dbId 51376
description
  • recommendedName: F-actin-capping protein subunit beta alternativeName: CapZ beta
displayName UniProt:P47756 CAPZB
geneName
  • CAPZB
identifier P47756
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Actin capping
  • Actin-binding
  • Alternative splicing
  • Cytoplasm
  • Cytoskeleton
  • Direct protein sequencing
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • CAPZB
otherIdentifier
  • 11720600_a_at
  • 16682704
  • 201949_3p_x_at
  • 201949_PM_x_at
  • 201949_x_at
  • 201950_PM_x_at
  • 201950_x_at
  • 2399766
  • 2399767
  • 2399768
  • 2399769
  • 2399770
  • 2399771
  • 2399772
  • 2399773
  • 2399774
  • 2399775
  • 2399776
  • 2399777
  • 2399778
  • 2399779
  • 2399780
  • 2399781
  • 2399782
  • 2399783
  • 2399784
  • 2399785
  • 2399786
  • 2399787
  • 2399788
  • 2399789
  • 2399798
  • 2399799
  • 2399800
  • 2399801
  • 2399802
  • 2399811
  • 2399812
  • 2399813
  • 2399814
  • 2399815
  • 2399816
  • 2399821
  • 2399822
  • 2399829
  • 2399833
  • 2399834
  • 2399835
  • 2399844
  • 2399854
  • 2399855
  • 2399860
  • 2399861
  • 37012_PM_at
  • 37012_at
  • 4901305_3p_s_at
  • 7913169
  • 79967_at
  • 832
  • A_23_P126752
  • A_33_P3235561
  • A_33_P3235562
  • A_33_P3235568
  • GE61350
  • GE85982
  • GO:0003779
  • GO:0005515
  • GO:0005737
  • GO:0005829
  • GO:0005856
  • GO:0005903
  • GO:0007010
  • GO:0008092
  • GO:0008154
  • GO:0008290
  • GO:0014069
  • GO:0015629
  • GO:0016020
  • GO:0022604
  • GO:0030017
  • GO:0030027
  • GO:0030030
  • GO:0030032
  • GO:0030036
  • GO:0030863
  • GO:0032279
  • GO:0043226
  • GO:0045296
  • GO:0051016
  • GO:0051693
  • GO:0070062
  • GO:0071203
  • GO:0098685
  • GO:0098686
  • GO:0120212
  • HMNXSV003011056
  • Hs.76368.0.S2_3p_s_at
  • ILMN_2053921
  • PH_hs_0016331
  • TC01002300.hg
  • TC01005305.hg
  • g4826658_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CAPZB_HUMAN
  • Q32Q68
  • Q5U0L4
  • Q8TB49
  • Q9NUC4
sequenceLength 272
species [Species:48887] Homo sapiens
stId uniprot:P47756
url http://purl.uniprot.org/uniprot/P47756

Referrals

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