Reactome | UniProt:P47112 TAH11

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UniProt:P47112 TAH11 Show undefined attributes

chain	chain:1-604
checksum	099992C0E3CCA726
comment	FUNCTION DNA replication licensing factor, required for pre-replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM2-7 helicase complex to the replication origins.SUBUNIT Associates with the MCM2-7 complex. Interacts with MCM2, ORC1, ORC2 and ORC6.INTERACTION Undergoes cell cycle-dependent changes in its nuclear localization. Exits the nucleus and remains in the cytoplasm during S phase through early mitosis, and re-accumulates in the nucleus around the end of mitosis.MISCELLANEOUS Present with 2190 molecules/cell in log phase SD medium.SIMILARITY Belongs to the Cdt1 family.
crossReference	[DatabaseIdentifier:12372848] RefSeq:NP_012580.1 [DatabaseIdentifier:12266956] PRO:P47112 [DatabaseIdentifier:12187434] PDB:5MEB [DatabaseIdentifier:12142003] PDB:9GM5 [DatabaseIdentifier:12149036] PDB:5XF8 [DatabaseIdentifier:12141985] PDB:9BCX [DatabaseIdentifier:12141990] PDB:5V8F [DatabaseIdentifier:12141992] PDB:6WGI [DatabaseIdentifier:12187435] PDB:5MEA [DatabaseIdentifier:12187433] PDB:5ME9 [DatabaseIdentifier:12142004] PDB:9GJP [DatabaseIdentifier:12141997] PDB:9GJW [DatabaseIdentifier:12187436] PDB:5MEC [DatabaseIdentifier:12141991] PDB:6WGG [DatabaseIdentifier:11695643] ENSEMBL:YJR046W_mRNA [DatabaseIdentifier:11572944] ENSEMBL:YJR046W [DatabaseIdentifier:11474274] ENSEMBL:YJR046W
databaseName	UniProt
dbId	106806
description	recommendedName: Cell division cycle protein CDT1 alternativeName: SIC1 indispensable protein 2 alternativeName: Topoisomerase-A hypersensitive protein 11
displayName	UniProt:P47112 TAH11
geneName	TAH11 CDT1 SID2 YJR046W J1641
identifier	P47112
isSequenceChanged	false
keyword	3D-structure Cell cycle Cell division Cytoplasm DNA-binding Mitosis Nucleus Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	TAH11
otherIdentifier	853504 GO:0000727 GO:0003677 GO:0003688 GO:0005515 GO:0005575 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006267 GO:0006281 GO:0006310 GO:0008150 GO:0030174 GO:0051052 GO:0051301
physicalEntity	[EntityWithAccessionedSequence:R-SCE-9749306] yCDT1 [nucleoplasm] - Saccharomyces cerevisiae
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12739292] UCSC:P47112 TAH11 [ReferenceDNASequence:12053405] NCBI Gene:853504 TAH11 [ReferenceDNASequence:11969312] Monarch:853504 TAH11 [ReferenceDNASequence:11880376] KEGG:sce:YJR046W TAH11 [ReferenceDNASequence:11339523] BioGPS Gene:853504 TAH11
referenceTranscript	[ReferenceRNASequence:12554620] RefSeq:NM_001181704.1 TAH11
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CDT1_YEAST D6VWL7
sequenceLength	604
species	[Species:68322] Saccharomyces cerevisiae
stId	uniprot:P47112
url	http://purl.uniprot.org/uniprot/P47112

Referrals

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(referenceEntity)

[EntityWithAccessionedSequence:R-SCE-9749306] yCDT1 [nucleoplasm]