Reactome | UniProt:P46778 RPL21

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UniProt:P46778 RPL21 Show undefined attributes

chain	initiator methionine:1 chain:2-160
checksum	C51D0B5E8EB9D69E
comment	FUNCTION Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688).SUBUNIT Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688).SUBCELLULAR LOCATION Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the eukaryotic ribosomal protein eL21 family.
crossReference	[DatabaseIdentifier:12148675] PDB:6OLI [DatabaseIdentifier:12423523] RefSeq:NP_000973.2 [DatabaseIdentifier:12288762] Pharos - Targets:P46778 [DatabaseIdentifier:12250032] PRO:P46778 [DatabaseIdentifier:12148775] PDB:8GLP [DatabaseIdentifier:12145978] PDB:8FL7 [DatabaseIdentifier:12148945] PDB:8FL9 [DatabaseIdentifier:12144892] PDB:8IPD [DatabaseIdentifier:12145982] PDB:8FKS [DatabaseIdentifier:12139130] PDB:8FL4 [DatabaseIdentifier:12145983] PDB:8FKT [DatabaseIdentifier:12148785] PDB:8YOO [DatabaseIdentifier:12145973] PDB:8FKW [DatabaseIdentifier:12148786] PDB:6Y57 [DatabaseIdentifier:12148940] PDB:8OJ8 [DatabaseIdentifier:12145981] PDB:8FKP [DatabaseIdentifier:12144885] PDB:8FL0 [DatabaseIdentifier:12148761] PDB:8XSX [DatabaseIdentifier:12139132] PDB:8FL3 [DatabaseIdentifier:12144883] PDB:8IPX [DatabaseIdentifier:12145974] PDB:8FKX [DatabaseIdentifier:12145976] PDB:8FL6 [DatabaseIdentifier:12148788] PDB:6IP6 [DatabaseIdentifier:12148792] PDB:8UIK [DatabaseIdentifier:12150999] PDB:7OW7 [DatabaseIdentifier:12148944] PDB:6LU8 [DatabaseIdentifier:12148757] PDB:8XSY [DatabaseIdentifier:12146421] PDB:6ZMI [DatabaseIdentifier:12145984] PDB:8FKQ [DatabaseIdentifier:12148770] PDB:8K2C [DatabaseIdentifier:12148768] PDB:8QOI [DatabaseIdentifier:12148947] PDB:7F5S [DatabaseIdentifier:12148941] PDB:6LSR [DatabaseIdentifier:12144887] PDB:8IR1 [DatabaseIdentifier:12148782] PDB:8YOP [DatabaseIdentifier:12148946] PDB:8QYX [DatabaseIdentifier:12148783] PDB:9G8M [DatabaseIdentifier:12148790] PDB:6IP8 [DatabaseIdentifier:12148766] PDB:6Z6N [DatabaseIdentifier:12144886] PDB:8IR3 [DatabaseIdentifier:12148942] PDB:6LSS [DatabaseIdentifier:12148765] PDB:6Z6L [DatabaseIdentifier:12145979] PDB:8FKY [DatabaseIdentifier:12148759] PDB:8XSZ [DatabaseIdentifier:12145977] PDB:8FKV [DatabaseIdentifier:12148943] PDB:9GY4 [DatabaseIdentifier:12148777] PDB:5AJ0 [DatabaseIdentifier:12146422] PDB:6ZMO [DatabaseIdentifier:12148764] PDB:6Z6M [DatabaseIdentifier:12139131] PDB:8FL2 [DatabaseIdentifier:12145980] PDB:8FKZ [DatabaseIdentifier:12144882] PDB:8IPY [DatabaseIdentifier:12145975] PDB:8FKU [DatabaseIdentifier:12145985] PDB:8FKR [DatabaseIdentifier:12148793] PDB:9B0F [DatabaseIdentifier:12148789] PDB:6IP5 [DatabaseIdentifier:12148659] PDB:8JDJ [DatabaseIdentifier:12148686] PDB:9B0P [DatabaseIdentifier:12144889] PDB:8INK [DatabaseIdentifier:12145969] PDB:8FLA [DatabaseIdentifier:12148687] PDB:9B11 [DatabaseIdentifier:12148729] PDB:6Y2L [DatabaseIdentifier:12148712] PDB:6OLZ [DatabaseIdentifier:12148688] PDB:8UIZ [DatabaseIdentifier:12148667] PDB:6OLF [DatabaseIdentifier:12148749] PDB:8IFD [DatabaseIdentifier:12148682] PDB:8Y0W [DatabaseIdentifier:12148663] PDB:9C3H [DatabaseIdentifier:12148737] PDB:6ZM7 [DatabaseIdentifier:12148750] PDB:7XNY [DatabaseIdentifier:12148685] PDB:8Y0X [DatabaseIdentifier:12148933] PDB:9GMO [DatabaseIdentifier:12148935] PDB:6LQM [DatabaseIdentifier:12148718] PDB:9AZC [DatabaseIdentifier:12148715] PDB:9AZN [DatabaseIdentifier:12144891] PDB:9QIW [DatabaseIdentifier:12148664] PDB:8UJJ [DatabaseIdentifier:12148680] PDB:9B0R [DatabaseIdentifier:12148717] PDB:5T2C [DatabaseIdentifier:12148662] PDB:6OM0 [DatabaseIdentifier:12148931] PDB:8IE3 [DatabaseIdentifier:12145972] PDB:8FLB [DatabaseIdentifier:12148927] PDB:8FLC [DatabaseIdentifier:12148691] PDB:8UIY [DatabaseIdentifier:12148934] PDB:8OJ0 [DatabaseIdentifier:12148741] PDB:9AZS [DatabaseIdentifier:12144890] PDB:8RL2 [DatabaseIdentifier:12148745] PDB:7XNX [DatabaseIdentifier:12148938] PDB:8QFD [DatabaseIdentifier:12145826] PDB:8IDY [DatabaseIdentifier:12148939] PDB:8OJ5 [DatabaseIdentifier:12148697] PDB:4V6X [DatabaseIdentifier:12148709] PDB:6OM7 [DatabaseIdentifier:12148744] PDB:8IFE [DatabaseIdentifier:12148696] PDB:9B0H [DatabaseIdentifier:12148679] PDB:9B0Q [DatabaseIdentifier:12145971] PDB:8FLE [DatabaseIdentifier:12148671] PDB:6OLG [DatabaseIdentifier:12148665] PDB:8G5Y [DatabaseIdentifier:12145968] PDB:8INE [DatabaseIdentifier:12148672] PDB:8G5Z [DatabaseIdentifier:12148703] PDB:8UKB [DatabaseIdentifier:12148669] PDB:6OLE [DatabaseIdentifier:12148714] PDB:5LKS [DatabaseIdentifier:12148684] PDB:8G60 [DatabaseIdentifier:12148930] PDB:7QVP [DatabaseIdentifier:12148937] PDB:8IDT [DatabaseIdentifier:12148926] PDB:6Y6X [DatabaseIdentifier:12148923] PDB:8UJC [DatabaseIdentifier:12148658] PDB:8JDM [DatabaseIdentifier:12145825] PDB:8INF [DatabaseIdentifier:12148695] PDB:9B0G [DatabaseIdentifier:12148660] PDB:8JDK [DatabaseIdentifier:12145970] PDB:8FLD [DatabaseIdentifier:12148661] PDB:8UJK [DatabaseIdentifier:12148733] PDB:6XA1 [DatabaseIdentifier:12148708] PDB:8G6J [DatabaseIdentifier:12148704] PDB:4UG0 [DatabaseIdentifier:12148694] PDB:9B0J [DatabaseIdentifier:11497616] ENSEMBL:ENSG00000122026 [DatabaseIdentifier:11606571] ENSEMBL:ENSP00000370574 [DatabaseIdentifier:11606570] ENSEMBL:ENSP00000346027 [DatabaseIdentifier:11606572] ENSEMBL:ENSP00000370569 [DatabaseIdentifier:11606569] ENSEMBL:ENSP00000351021 [DatabaseIdentifier:11729269] ENSEMBL:ENST00000272274 [DatabaseIdentifier:11729271] ENSEMBL:ENST00000319826 [DatabaseIdentifier:11729268] ENSEMBL:ENST00000311549 [DatabaseIdentifier:11729270] ENSEMBL:ENST00000326092 [DatabaseIdentifier:11790920] GeneCards:RPL21 [DatabaseIdentifier:11806848] GlyGen:P46778 [DatabaseIdentifier:11843924] HPA:ENSG00000122026-RPL21 [DatabaseIdentifier:12128541] OpenTargets:ENSG00000122026 [DatabaseIdentifier:12136794] Orphanet:RPL21 [DatabaseIdentifier:12148678] PDB:8G61 [DatabaseIdentifier:12148716] PDB:6QZP [DatabaseIdentifier:12148698] PDB:9B0N [DatabaseIdentifier:12148683] PDB:9B0O [DatabaseIdentifier:12148925] PDB:8FLF [DatabaseIdentifier:12148668] PDB:9B0W [DatabaseIdentifier:12148676] PDB:8UJB [DatabaseIdentifier:12148929] PDB:7BHP [DatabaseIdentifier:12148924] PDB:8UJD [DatabaseIdentifier:12148690] PDB:9B0S [DatabaseIdentifier:12148932] PDB:8OHD [DatabaseIdentifier:12148936] PDB:6W6L [DatabaseIdentifier:12148657] PDB:8JDL [DatabaseIdentifier:12148928] PDB:8A3D [DatabaseIdentifier:12148730] PDB:6ZME [DatabaseIdentifier:12148689] PDB:8UJ9 [DatabaseIdentifier:12148699] PDB:6Y0G
databaseName	UniProt
dbId	72425
description	recommendedName: fullName evidence="8"Large ribosomal subunit protein eL21 alternativeName: 60S ribosomal protein L21
displayName	UniProt:P46778 RPL21
geneName	RPL21
identifier	P46778
isSequenceChanged	false
keyword	3D-structure Cytoplasm Direct protein sequencing Disease variant Endoplasmic reticulum Hypotrichosis Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	RPL21
otherIdentifier	11753680_x_at 11755203_x_at 16719008 16773473 16773478 16773485 16773491 200012_PM_x_at 200012_x_at 2324529 2324531 2454592 2454593 2555855 2555857 2699539 2720538 2723714 2769515 2785024 2792397 2897332 2982245 2991784 2991785 3220079 3220081 32337_at 3263507 3282866 3309937 3309938 3309939 3309940 3319995 3420401 3423146 3423148 3423150 3423151 3473356 3482820 3482821 3482822 3482823 3482824 3482825 3482826 3482829 3482830 3482831 3482832 3482833 3482834 3482835 3482836 3482837 3482838 3482839 3482840 3482842 3568794 3627018 3634803 3679669 3679670 3679671 3714829 3714831 3800707 3800710 3982151 3984756 6144 7892680 7893259 7894125 7896036 7924144 7936727 7968226 7968232 7968234 7999360 8131661 A_14_P200364 A_19_P00807415 A_21_P0000262 A_23_P2725 A_32_P234738 GE80973 GE85909 GO:0002181 GO:0003723 GO:0003735 GO:0005198 GO:0005515 GO:0005737 GO:0005783 GO:0005829 GO:0005840 GO:0006412 GO:0016020 GO:0022625 GO:0022626 GO:0045202 GO:1990904 HMNXSV003010154 HMNXSV003014280 HMNXSV003054397 HMNXSV003055480 ILMN_2290808 PH_hs_0029970 PH_hs_0033032 PH_hs_0038942 RNA33539\|snoRNA_scaRNA_135_126 RNA33716\|snoRNA_scaRNA_312_72 TC07002180.hg TC13000073.hg TC13000978.hg U25789_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-72426] RPL21 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000122026] ENSEMBL:ENSG00000122026 RPL21 [ReferenceDNASequence:12701324] UCSC:P46778 RPL21 [ReferenceDNASequence:11363151] BioGPS Gene:6144 RPL21 [ReferenceDNASequence:11394368] COSMIC - genes:RPL21 RPL21 [ReferenceDNASequence:11418454] CTD Gene:6144 RPL21 [ReferenceDNASequence:11430433] dbSNP Gene:6144 RPL21 [ReferenceDNASequence:11822584] HGNC:10313 RPL21 [ReferenceDNASequence:11901941] KEGG:hsa:6144 RPL21 [ReferenceDNASequence:11992940] Monarch:6144 RPL21 [ReferenceDNASequence:12077033] NCBI Gene:6144 RPL21 [ReferenceDNASequence:12113297] OMIM:603636 RPL21
referenceTranscript	[ReferenceRNASequence:12605103] RefSeq:NM_000982.3 RPL21
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RL21_HUMAN Q16699
sequenceLength	160
species	[Species:48887] Homo sapiens
stId	uniprot:P46778
url	http://purl.uniprot.org/uniprot/P46778

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-72426] RPL21 [cytosol]
(interactor)	[UndirectedInteraction:11138249] UniProt:P63244 <-> UniProt:P46778 (IntAct) [UndirectedInteraction:11147927] UniProt:P13569 <-> UniProt:P46778 (IntAct) [UndirectedInteraction:11218691] UniProt:P10636-8 <-> UniProt:P46778 (IntAct) [UndirectedInteraction:11245757] UniProt:Q12906 <-> UniProt:P46778 (IntAct) [UndirectedInteraction:11281161] UniProt:P19320 <-> UniProt:P46778 (IntAct)

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