UniProt:P46721 SLCO1A2

chain
  • chain:1-670
checksum C3A740CEF1E6F129
comment
  • FUNCTION Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane (PubMed:19129463, PubMed:7557095). Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate) (PubMed:11159893, PubMed:12568656, PubMed:19129463, PubMed:23918469, PubMed:25560245, PubMed:9539145). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision (PubMed:25560245). Involved in the uptake of clinically used drugs (PubMed:17301733, PubMed:20686826, PubMed:27777271). Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (PubMed:19129463, PubMed:20358049). Also transports prostaglandin E2 (PubMed:19129463). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable).CATALYTIC ACTIVITY taurocholate(out) = taurocholate(in)CATALYTIC ACTIVITY glycocholate(out) = glycocholate(in)CATALYTIC ACTIVITY taurochenodeoxycholate(out) = taurochenodeoxycholate(in)CATALYTIC ACTIVITY tauroursodeoxycholate(out) = tauroursodeoxycholate(in)CATALYTIC ACTIVITY dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in)CATALYTIC ACTIVITY estrone 3-sulfate(out) = estrone 3-sulfate(in)CATALYTIC ACTIVITY 3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)CATALYTIC ACTIVITY L-thyroxine(out) = L-thyroxine(in)CATALYTIC ACTIVITY taurodeoxycholate(out) = taurodeoxycholate(in)CATALYTIC ACTIVITY glycodeoxycholate(out) = glycodeoxycholate(in)CATALYTIC ACTIVITY glycochenodeoxycholate(out) = glycochenodeoxycholate(in)CATALYTIC ACTIVITY glycoursodeoxycholate(out) = glycoursodeoxycholate(in)CATALYTIC ACTIVITY 17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in)CATALYTIC ACTIVITY prostaglandin E2(out) = prostaglandin E2(in)CATALYTIC ACTIVITY substance P(out) = substance P(in)ACTIVITY REGULATION Transport activity is inhibited by the grapefruit juice component naringin.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 6.5 with estrone 3-sulfate, taurocholate, prostaglandin E2 and L-thyroxine (T4) as substrates.INTERACTION Localized to the basal membrane of Sertoli cells.ALTERNATIVE PRODUCTS Higher expression in the brain than in liver and kidney (PubMed:15632119, PubMed:7557095, PubMed:9539145). Expressed in brain neurons in both cortex and hippocampus (PubMed:10873595, PubMed:25132355). Expressed in placental trophoblasts (PubMed:12409283). Also expressed in lung and testes at lower levels (PubMed:7557095). Expressed in the eye (at protein level) (PubMed:25560245). Expressed in the retina in the outer and inner nuclear layers, the inner plexiform layer and the ganglion cell layer (PubMed:25132355). Expressed in liver and prostate (PubMed:10873595). In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and within the tubules (PubMed:35307651). Expressed in fetal brain and liver (PubMed:10873595).DOMAIN A conserved histidine residue in the third TMD (His-107) may play an essential role in the pH sensitivity of SLCO1A2/OATP1A2-mediated substrate transport.SIMILARITY Belongs to the organo anion transporter (TC 2.A.60) family.
crossReference
databaseName UniProt
dbId 63992
description
  • recommendedName: Solute carrier organic anion transporter family member 1A2 shortName evidence="23"OATP1A2 alternativeName: fullName evidence="23"OATP-A alternativeName: Organic anion-transporting polypeptide 1 shortName evidence="23"OATP-1 alternativeName: Sodium-independent organic anion transporter alternativeName: Solute carrier family 21 member 3
displayName UniProt:P46721 SLCO1A2
geneName
  • SLCO1A2
  • OATP
  • OATP1
  • OATP1A2
  • SLC21A3
identifier P46721
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Ion transport
  • Lipid transport
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • SLCO1A2
otherIdentifier
  • 11731188_a_at
  • 11741711_a_at
  • 11758078_s_at
  • 11762524_at
  • 16762053
  • 207308_PM_at
  • 207308_at
  • 211480_PM_s_at
  • 211480_s_at
  • 211481_PM_at
  • 211481_at
  • 33552_at
  • 3446719
  • 3446720
  • 3446721
  • 3446723
  • 3446725
  • 3446727
  • 3446729
  • 3446730
  • 3446732
  • 3446733
  • 3446734
  • 3446735
  • 3446736
  • 3446737
  • 3446738
  • 3446739
  • 3446740
  • 3446741
  • 3446744
  • 3446750
  • 3446751
  • 3446752
  • 3446753
  • 3446754
  • 3446755
  • 3446758
  • 3446759
  • 3446761
  • 3446762
  • 3446763
  • 3446766
  • 3446768
  • 3446769
  • 3446770
  • 3446779
  • 3446781
  • 3446782
  • 47282_at
  • 6579
  • 7961626
  • A_23_P13820
  • A_24_P292542
  • A_32_P69802
  • A_33_P3236297
  • A_33_P3316770
  • GE59011
  • GO:0005215
  • GO:0005515
  • GO:0005886
  • GO:0006805
  • GO:0006811
  • GO:0006869
  • GO:0008514
  • GO:0009925
  • GO:0015101
  • GO:0015125
  • GO:0015347
  • GO:0015695
  • GO:0015711
  • GO:0015721
  • GO:0016020
  • GO:0016323
  • GO:0016324
  • GO:0022857
  • GO:0043252
  • GO:0055085
  • HMNXSV003006300
  • HMNXSV003016653
  • HMNXSV003050154
  • HMNXSV003052624
  • ILMN_1656097
  • ILMN_1680016
  • ILMN_1720727
  • ILMN_1806979
  • ILMN_2381020
  • PH_hs_0003286
  • PH_hs_0031204
  • TC12001295.hg
  • U21943_at
  • g10835098_3p_at
  • g5817298_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SO1A2_HUMAN
  • Q9UGP7
  • Q9UL38
sequenceLength 670
species [Species:48887] Homo sapiens
stId uniprot:P46721
url http://purl.uniprot.org/uniprot/P46721
Cite Us!