Reactome | UniProt:P46092 CCR10

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UniProt:P46092 CCR10 Show undefined attributes

chain	chain:1-362
checksum	736EB9B639AEA99A
comment	FUNCTION Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.INTERACTION Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.SIMILARITY Belongs to the G-protein coupled receptor 1 family.ONLINE INFORMATION CC chemokine receptors entry
crossReference	[DatabaseIdentifier:12816404] ZINC target:P46092 [DatabaseIdentifier:12813006] ZINC - Substances:CCR10_HUMAN [DatabaseIdentifier:12414695] RefSeq:NP_057686.2 [DatabaseIdentifier:12285848] Pharos - Targets:P46092 [DatabaseIdentifier:12245589] PRO:P46092 [DatabaseIdentifier:12125564] OpenTargets:ENSG00000184451 [DatabaseIdentifier:11841017] HPA:ENSG00000184451-CCR10 [DatabaseIdentifier:11832532] HMDB Protein:HMDBP07573 [DatabaseIdentifier:11787948] GeneCards:CCR10 [DatabaseIdentifier:11779250] Guide to Pharmacology - Targets:67 [DatabaseIdentifier:11723295] ENSEMBL:ENST00000332438 [DatabaseIdentifier:11600596] ENSEMBL:ENSP00000332504 [DatabaseIdentifier:11493210] ENSEMBL:ENSG00000184451
databaseName	UniProt
dbId	52198
description	recommendedName: C-C chemokine receptor type 10 shortName: C-C CKR-10 shortName: CC-CKR-10 shortName: CCR-10 alternativeName: G-protein coupled receptor 2
displayName	UniProt:P46092 CCR10
geneName	CCR10 GPR2
identifier	P46092
isSequenceChanged	false
keyword	Cell membrane Disulfide bond G-protein coupled receptor Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	CCR10
otherIdentifier	11729900_at 16845219 220565_PM_at 220565_at 2826 3758063 3758064 3758065 3758066 3758068 3758070 8015681 ADDON002811.hg A_23_P141367 A_33_P3221303 GE550983 GO:0002376 GO:0004930 GO:0004950 GO:0005515 GO:0005783 GO:0005886 GO:0006935 GO:0006955 GO:0007165 GO:0007186 GO:0007204 GO:0009897 GO:0009986 GO:0016020 GO:0016493 GO:0019722 GO:0019957 GO:0048870 GO:0060326 GO:0070098 HMNXSV003030632 ILMN_1666493 PH_hs_0014279 TC17001539.hg g7705315_3p_at p6829
physicalEntity	[EntityWithAccessionedSequence:R-HSA-373126] CCR10 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12698714] UCSC:P46092 CCR10 [ReferenceDNASequence:12110861] OMIM:600240 CCR10 [ReferenceDNASequence:12072679] NCBI Gene:2826 CCR10 [ReferenceDNASequence:11988586] Monarch:2826 CCR10 [ReferenceDNASequence:11897994] KEGG:hsa:2826 CCR10 [ReferenceDNASequence:11819597] HGNC:4474 CCR10 [ReferenceDNASequence:11430195] dbSNP Gene:2826 CCR10 [ReferenceDNASequence:11413974] CTD Gene:2826 CCR10 [ReferenceDNASequence:11394148] COSMIC - genes:CCR10 CCR10 [ReferenceDNASequence:11358797] BioGPS Gene:2826 CCR10 [ReferenceDNASequence:ensembl:ENSG00000184451] ENSEMBL:ENSG00000184451 CCR10
referenceTranscript	[ReferenceRNASequence:12596393] RefSeq:NM_016602.3 CCR10
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CCR10_HUMAN Q4V749 Q6T7X2 Q9NZG2
sequenceLength	362
species	[Species:48887] Homo sapiens
stId	uniprot:P46092
url	http://purl.uniprot.org/uniprot/P46092

Referrals

(interactor)	[UndirectedInteraction:11268109] UniProt:P46092 <-> UniProt:O15145 (IntAct) [UndirectedInteraction:11268107] UniProt:P46092 <-> UniProt:P60903 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-373126] CCR10 [plasma membrane]