Reactome | UniProt:P43407 Sdc2

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UniProt:P43407 Sdc2 Show undefined attributes

chain	signal peptide:1-18 chain:19-202
checksum	C213D1B64D88376F
comment	FUNCTION Cell surface proteoglycan which regulates dendritic arbor morphogenesis.SUBUNIT Interacts (via cytoplasmic domain) with SARM1 (PubMed:21555464). Forms a complex with SDCBP and PDCD6IP (By similarity).INTERACTION Preferential expression in cells of mesenchymal origin.PTM O-glycosylated; contains both heparan sulfate and chondroitin sulfate.PTM Phosphorylated on serine residues.SIMILARITY Belongs to the syndecan proteoglycan family.
crossReference	[DatabaseIdentifier:11484034] ENSEMBL:ENSMUSG00000022261 [DatabaseIdentifier:12393742] RefSeq:NP_032330.1 [DatabaseIdentifier:12277695] PRO:P43407 [DatabaseIdentifier:11936444] MGI:1349165 [DatabaseIdentifier:11812234] GlyGen:P43407 [DatabaseIdentifier:11709124] ENSEMBL:ENSMUST00000022871 [DatabaseIdentifier:11586425] ENSEMBL:ENSMUSP00000022871
databaseName	UniProt
dbId	101281
description	recommendedName: Syndecan-2 shortName: SYND2 alternativeName: Fibroglycan alternativeName: Heparan sulfate proteoglycan core protein shortName: HSPG cdAntigenNameCD362/cdAntigenName
displayName	UniProt:P43407 Sdc2
geneName	Sdc2 Hspg1 Synd2
identifier	P43407
isSequenceChanged	false
keyword	Differentiation Glycoprotein Heparan sulfate Membrane Neurogenesis Phosphoprotein Proteoglycan Reference proteome Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	Sdc2
otherIdentifier	10423548 1417011_at 1417012_at 1448545_at 15529 17310872 4308175 4334044 4519247 4526002 4780664 4943847 5037948 5058243 5181601 5300490 5385165 5442723 5543708 5566656 95104_at A_51_P157255 A_51_P292403 GE42518 GO:0005515 GO:0005796 GO:0005886 GO:0007399 GO:0009986 GO:0016020 GO:0016477 GO:0030154 GO:0030165 GO:0042802 GO:0048813 GO:0048814 GO:0048856 GO:0048870 ILMN_2619983 U00674_s_at mMC023554
physicalEntity	[EntityWithAccessionedSequence:R-MMU-2090052] Sdc2 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-4093306] phospho-Sdc2 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076683] Sdc2 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076661] Sdc2 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076644] Sdc2 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076643] Sdc2 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076631] Sdc2 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076665] Sdc2 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-8956741] Sdc2 [endoplasmic reticulum lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-8956945] phospho-Sdc2 [endoplasmic reticulum lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2054101] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2064109] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2064132] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2063988] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2063997] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076608] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076536] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076397] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076361] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076576] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076607] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076603] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076443] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2161462] HS(1)-Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2161438] HS(2)-Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076356] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076320] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2076588] Sdc2 [Golgi lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-2090064] Sdc2 [lysosomal lumen] - Mus musculus [EntityWithAccessionedSequence:R-MMU-9941144] Sdc2 [Golgi lumen] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11349412] BioGPS Gene:15529 Sdc2 [ReferenceDNASequence:12695145] UCSC:P43407 Sdc2 [ReferenceDNASequence:12063294] NCBI Gene:15529 Sdc2 [ReferenceDNASequence:11979201] Monarch:15529 Sdc2 [ReferenceDNASequence:11889296] KEGG:mmu:15529 Sdc2
referenceTranscript	[ReferenceRNASequence:12575498] RefSeq:NM_008304.2 Sdc2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	SDC2_MOUSE
sequenceLength	202
species	[Species:48892] Mus musculus
stId	uniprot:P43407
url	http://purl.uniprot.org/uniprot/P43407

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-2090052] Sdc2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-4093306] phospho-Sdc2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-2076683] Sdc2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-2076661] Sdc2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-2076644] Sdc2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-2076643] Sdc2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-2076631] Sdc2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-2076665] Sdc2 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-8956741] Sdc2 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-MMU-8956945] phospho-Sdc2 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-MMU-2054101] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2064109] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2064132] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2063988] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2063997] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076608] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076536] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076397] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076361] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076576] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076607] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076603] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076443] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2161462] HS(1)-Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2161438] HS(2)-Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076356] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076320] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2076588] Sdc2 [Golgi lumen] [EntityWithAccessionedSequence:R-MMU-2090064] Sdc2 [lysosomal lumen] [EntityWithAccessionedSequence:R-MMU-9941144] Sdc2 [Golgi lumen]
(referenceSequence)	[GroupModifiedResidue:9993767] O-xylosyl-L-serine (ChEBI:63657) at unknown position [GroupModifiedResidue:9993837] O-xylosyl-L-serine (ChEBI:63666) at unknown position [GroupModifiedResidue:2161415] O-xylosyl-L-serine (beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-IdoA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at unknown position [GroupModifiedResidue:2161426] O-xylosyl-L-serine (beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at unknown position [GroupModifiedResidue:9993732] O-xylosyl-L-serine (ChEBI:63654) at unknown position [GroupModifiedResidue:9993802] O-xylosyl-L-serine (ChEBI:63661) at unknown position [ModifiedResidue:10083511] phosphorylated residue at unknown position [ModifiedResidue:10037030] O-xylosyl-L-serine at unknown position [GroupModifiedResidue:10037201] O-xylosyl-L-serine (O3-(4-?-D-galactosyl-?-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:10037099] O-xylosyl-L-serine (O3-(?-D-galactosyl-(1?3)-?-D-galactosyl-(1?4)-?-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:10035759] O-xylosyl-L-serine (3-O-(?-D-glucuronosyl-(1?3)-?-D-galactosyl-(1?3)-?-D-galactosyl-(1?4)-?-D-xylosyl)-L-serine residue) at unknown position [GroupModifiedResidue:10040091] O-xylosyl-L-serine (ChEBI:63645) at unknown position [GroupModifiedResidue:10040008] O-xylosyl-L-serine (ChEBI:63646) at unknown position [GroupModifiedResidue:10040043] O-xylosyl-L-serine (ChEBI:63648) at unknown position [GroupModifiedResidue:10040203] O-xylosyl-L-serine (ChEBI:63649) at unknown position [GroupModifiedResidue:10040129] O-xylosyl-L-serine (ChEBI:63651) at unknown position [GroupModifiedResidue:10097638] O-xylosyl-L-serine (O3-(?-D-glucuronosyl-(1?3)-?-D-galactosyl-(1?3)-?-D-galactosyl-(1?4)-?-D-2-O-phospho-xylosyl)-L-serine residue) at unknown position [ModifiedResidue:10050577] O4'-phospho-L-tyrosine at 191 (in Homo sapiens) [ModifiedResidue:10050576] O4'-phospho-L-tyrosine at 179 (in Homo sapiens)
(interactor)	[UndirectedInteraction:11132661] UniProt:P43407 <-> UniProt:Q15113 (IntAct)

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