Reactome | UniProt:P42702 LIFR

Schema > ReferenceGeneProduct > Entries

UniProt:P42702 LIFR Show undefined attributes

chain	signal peptide:1-44 chain:45-1097
checksum	C8602897E359FCE5
comment	FUNCTION Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.SUBUNIT Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR.INTERACTION The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1.SIMILARITY Belongs to the type I cytokine receptor family. Type 2 subfamily.
crossReference	[DatabaseIdentifier:11466665] ENSEMBL:ENSG00000113594 [DatabaseIdentifier:11562274] ENSEMBL:ENSP00000263409 [DatabaseIdentifier:11562275] ENSEMBL:ENSP00000398368 [DatabaseIdentifier:11684973] ENSEMBL:ENST00000453190 [DatabaseIdentifier:11684974] ENSEMBL:ENST00000263409 [DatabaseIdentifier:11780860] Guide to Pharmacology - Targets:1713 [DatabaseIdentifier:11783875] GeneCards:LIFR [DatabaseIdentifier:11799402] GlyGen:P42702 [DatabaseIdentifier:11836979] HPA:ENSG00000113594-LIFR [DatabaseIdentifier:12121466] OpenTargets:ENSG00000113594 [DatabaseIdentifier:12136217] Orphanet:LIFR [DatabaseIdentifier:12142095] PDB:8D74 [DatabaseIdentifier:12142102] PDB:8V2A [DatabaseIdentifier:12142092] PDB:8D6A [DatabaseIdentifier:12142105] PDB:8V29 [DatabaseIdentifier:12142104] PDB:8D7R [DatabaseIdentifier:12154442] PDB:3E0G [DatabaseIdentifier:12259751] PRO:P42702 [DatabaseIdentifier:12281791] Pharos - Targets:P42702 [DatabaseIdentifier:12354038] RefSeq:NP_001351226.1 [DatabaseIdentifier:12354040] RefSeq:XP_011512344.1 [DatabaseIdentifier:12354041] RefSeq:NP_001121143.1 [DatabaseIdentifier:12354039] RefSeq:XP_016864952.1 [DatabaseIdentifier:12354037] RefSeq:NP_002301.1
databaseName	UniProt
dbId	58565
description	recommendedName: Leukemia inhibitory factor receptor shortName: LIF receptor shortName: LIF-R cdAntigenNameCD118/cdAntigenName
displayName	UniProt:P42702 LIFR
geneName	LIFR
identifier	P42702
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Chromosomal rearrangement Disease variant Disulfide bond Glycoprotein Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	LIFR
otherIdentifier	11722685_s_at 11722686_a_at 11722687_a_at 11722688_a_at 11758145_s_at 16995500 16995534 205876_PM_at 205876_at 225571_PM_at 225571_at 225575_PM_at 225575_at 227771_PM_at 227771_at 229185_PM_at 229185_at 2854075 2854077 2854079 2854081 2854083 2854085 2854087 2854089 2854090 2854091 2854093 2854094 2854095 2854096 2854098 2854099 2854100 2854101 2854103 2854104 2854105 2854108 2854111 2854112 2854113 2854115 2854116 2854117 2854118 2854119 2854121 2854124 2854125 2854126 2854127 2854128 2854129 2854131 2854136 2854147 2854148 2854151 2854152 39617_at 3977 50408_at 56211_at 58445_at 59486_at 8111677 A_24_P325992 A_24_P397386 GE58283 GE59870 GO:0004896 GO:0004897 GO:0004923 GO:0004924 GO:0005127 GO:0005515 GO:0005576 GO:0005886 GO:0007166 GO:0008284 GO:0009897 GO:0016020 GO:0019221 GO:0019838 GO:0019955 GO:0034097 GO:0038165 GO:0043235 GO:0048861 GO:0070062 GO:0070120 HMNXSV003004441 HMNXSV003022692 HMNXSV003034176 Hs.124963.0.A1_3p_at Hs.23767.1.A1_3p_at Hs.23767.2.A1_3p_at Hs.23767.2.A1_3p_x_at Hs.23767.2.A2_3p_at ILMN_1709094 PH_hs_0026101 S83362_s_at TC05001289.hg TC05001290.hg U78628_at X61615_at g6042197_3p_at p28609
physicalEntity	[EntityWithAccessionedSequence:R-HSA-5693181] LIFR [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000113594] ENSEMBL:ENSG00000113594 LIFR [ReferenceDNASequence:12682179] UCSC:P42702 LIFR [ReferenceDNASequence:11331141] BioGPS Gene:3977 LIFR [ReferenceDNASequence:11392359] COSMIC - genes:LIFR LIFR [ReferenceDNASequence:11407629] CTD Gene:3977 LIFR [ReferenceDNASequence:11428129] dbSNP Gene:3977 LIFR [ReferenceDNASequence:11815497] HGNC:6597 LIFR [ReferenceDNASequence:11872961] KEGG:hsa:3977 LIFR [ReferenceDNASequence:11960930] Monarch:3977 LIFR [ReferenceDNASequence:12045023] NCBI Gene:3977 LIFR [ReferenceDNASequence:12107161] OMIM:151443 LIFR
referenceTranscript	[ReferenceRNASequence:12535905] RefSeq:NM_002310.6 LIFR [ReferenceRNASequence:12535903] RefSeq:NM_001364297.2 LIFR [ReferenceRNASequence:12535904] RefSeq:XM_017009463.2 LIFR [ReferenceRNASequence:12535902] RefSeq:NM_001127671.2 LIFR [ReferenceRNASequence:12535901] RefSeq:XM_011514042.4 LIFR
schemaClass	ReferenceGeneProduct
secondaryIdentifier	LIFR_HUMAN Q6LCD9
sequenceLength	1097
species	[Species:48887] Homo sapiens
stId	uniprot:P42702
url	http://purl.uniprot.org/uniprot/P42702

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-HSA-5693181] LIFR [plasma membrane]

(interactor)