UniProt:P42684 ABL2

chain
  • initiator methionine:1
  • chain:2-1182
checksum ED93869BC2B14FAA
comment
  • FUNCTION Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 also acts as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity).CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML). Phosphatidylinositol 4,5-bisphosphate (PIP2), a highly abundant phosphoinositide known to regulate cytoskeletal and membrane proteins, inhibits the tyrosine kinase activity (By similarity).SUBUNIT Interacts with PSMA7. Interacts with CTTN. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.INTERACTION Widely expressed.DOMAIN Contains two distinct classes of F-actin-binding domains. Although both can bind F-actin, the 2 are required to bundle actin filaments (By similarity).PTM Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity).PTM Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.SEQUENCE CAUTION Extended N-terminus.
crossReference
databaseName UniProt
dbId 49456
description
  • recommendedName: Tyrosine-protein kinase ABL2 ecNumber: 2.7.10.2 alternativeName: Abelson murine leukemia viral oncogene homolog 2 alternativeName: Abelson tyrosine-protein kinase 2 alternativeName: Abelson-related gene protein alternativeName: Tyrosine-protein kinase ARG
displayName UniProt:P42684 ABL2
geneName
  • ABL2
  • ABLL
  • ARG
identifier P42684
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • ATP-binding
  • Cell adhesion
  • Cytoplasm
  • Cytoskeleton
  • Kinase
  • Lipoprotein
  • Magnesium
  • Manganese
  • Metal-binding
  • Myristate
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • SH2 domain
  • SH3 domain
  • Transferase
  • Tyrosine-protein kinase
  • Ubl conjugation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • ABL2
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ABL2_HUMAN
  • A0M8X0
  • B7UEF2
  • B7UEF3
  • B7UEF4
  • B7UEF5
  • Q5T0X6
  • Q5W0C5
  • Q6NZY6
  • Q7Z301
sequenceLength 1182
species [Species:48887] Homo sapiens
stId uniprot:P42684
url http://purl.uniprot.org/uniprot/P42684
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